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Cited by 11Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Candida infanticola and Candida spencermartinsiae yeasts: Possible emerging species in cancer patients

Shokohi, Tahereh, Aslani, Narges, Ahangarkani, Fatemeh, Meyabadi, Masoumeh Fatahi, Hagen, Ferry, Meis, Jacques F., Boekhout, Teun, Kolecka, Anna +1 more·2018·Microbial Pathogenesis
DOI 10.1016/j.micpath.2017.12.069
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Abstract

Opportunistic infections due to Candida species occur frequently in intensive care settings. We investigated the prevalence of Candida species among 65 clinical specimens obtained from 200 cancer patients by phenotypic and molecular (ITS sequencing and AFLP) methods. Among the 65 yeast isolates, Candida albicans was the most commonly isolated species (n = 34, 52.3%), whereas other Candida species comprised 47.7% (n = 31) and consisted of Candida glabrata (n = 14, 21.5%), Candida tropicalis (n = 5, 7.7%) and uncommon Candida species (n = 12, 18.5%) such as Candida pelliculosa (n = 3, 4.6%), Pichia kudriavzevii (= Candida krusei, n = 2, 3.1%), Candida orthopsilosis (n = 2, 3.1%), Candida parapsilosis (n = 1, 1.5%), Candida infanticola (n = 2, 3.1%), Candida spencermartinsiae (n = 1, 1.5%), and Kluyveromyces marxianus (=Candida kefyr, n = 1, 1.5%). Candida infanticola and Candida spencermartinsiae were recovered from oral lesions of cancer patients. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) easily confirmed these isolates as less common Candida isolates (4.6%). The in vitro antifungal susceptibilities of C. spencermartinsiae and the two strains of C. infanticola were determined according to CLSI guidelines (M27-A3). MIC results among these isolates showed they were susceptible to isavuconazole, posaconazole and voriconazole, however, fluconazole and caspofungin had high MIC values. These Candida species that may occur more commonly in infections remain unnoticed using commonly used phenotypical methods in routine microbiology laboratories. MALDI-TOF MS proved to be a more fast and robust diagnostic technique for identification of the yeasts isolated from different clinical specimens of cancer patients.

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Crossref · 10.1016/j.micpath.2017.12.069

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  • Aslani et al. reported that 39% of yeast strains from cancer patients showed higher MIC values to amphotericin B, with MIC90 values of 4 μg/mL.

    “The study of Aslani et al. [111] reported that 39% of yeast strains from cancer patients showed higher MIC values to AmB, with MIC90 values of 4 μg/mL.”

    From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [111]

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Authors
Shokohi, T., Aslani, N., Ahangarkani, F., Meyabadi, M. F., Hagen, F., Meis, J. F., Boekhout, T., Kolecka, A., & Badali, H.
Affiliations
  • Mazandaran University of Medical Sciences (IR)
  • Radboud University Medical Center (NL)
  • Second Military Medical University (CN)
  • Westerdijk Fungal Biodiversity Institute (NL)
Corresponding author
Badali, Hamid
ORCID
Venue
Microbial Pathogenesis
Publisher
Elsevier BV
Published
2018-02
Volume
115
Pages
353-357
ISSN
0882-4010 (ISSN-L)
DOI
10.1016/j.micpath.2017.12.069
OpenAlex
W2779194960
Cited by
11
References
31
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 3 · 2018: 1
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Microbial Pathogenesis (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
School of Medicine, Mazandaran University of Medical Sciences (84/66)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
opportunistic fungal infection, cancer patients, oral candidiasis, Candida albicans, Candida glabrata, Candida tropicalis, antifungal susceptibility, isavuconazole, posaconazole, voriconazole, fluconazole, caspofungin, ITS sequencing, AFLP
MeSH terms
Caspofungin, Adolescent, Antifungal Agents, Candida, Candidiasis, Child, Preschool, Humans, Kluyveromyces, Male, Microbial Sensitivity Tests, Middle Aged, Neoplasms, Nitriles, Opportunistic Infections, Pichia, Pyridines, Triazoles, Fluconazole, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Echinocandins, Lipopeptides, Voriconazole

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