Evaluation of anti-diabetic attributes of Lactobacillus rhamnosus MTCC: 5957, Lactobacillus rhamnosus MTCC: 5897 and Lactobacillus fermentum MTCC: 5898 in streptozotocin induced diabetic rats
Abstract
Interest in probiotics has grown significantly in the last decades due to their reported nutritional and health promoting effects. The aim of this study is to investigate the therapeutic potential of probiotic fermented milk (PFM) prepared using three different probiotic strains i.e. Lactobacillus rhamnosus MTCC: 5957, Lactobacillus rhamnosus MTCC: 5897 and Lactobacillus fermentum MTCC: 5898; independently or in combination, for treating streptozotocin induced type-1 diabetes in male Wistar rats. Diabetic rats were fed with PFM preparations for 6 weeks and then analyzed for the various biochemical parameters associated. The results indicated that feeding of PFM significantly improved glucose metabolism (fasting blood glucose, glycated hemoglobin, serum insulin), serum inflammation status (tumor necrosis factor-α, and serum interleukin-6), oxidative stress (thiobarbituric acid reactive substance, catalase, superoxide dismutase and glutathione peroxidase activities in liver and kidney), serum lipid profile (total cholesterol, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, triglycerides) in diabetic rats. In addition, feeding of PFM has significantly reduced mRNA expression of pepck and g6pase genes that code the key enzymes of gluconeogenesis pathway. The results of this study showed that daily consumption of PFM can be effective in combating of type -1 diabetes and its complications.
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Previous studies have confirmed the efficacy of reducing lipids in rats fed high-fat diets using L. rhamnosus and L. fermentans.
“Previous studies have confirmed the efficacy of reducing lipids in rats fed high-fat diets using L. rhamnosus and L. fermentans (Yadav et al., 2018; Thakkar et al., 2020; Zafar et al., 2022).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Yadav et al., 2018
Some probiotics are effective in reducing lipid concentrations and lipid deposition in rats fed with a high-fat diet.
“Interestingly, some probiotics are effective in reducing lipid concentrations and lipid deposition in rats fed with a high-fat diet.”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Yadav et al., 2018
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- Authors
- Yadav, R., Dey, D. K., Vij, R., Meena, S., Kapila, R., & Kapila, S.
- Affiliations
- Indian Council of Agricultural Research (IN)
- National Dairy Research Institute (IN)
- Corresponding author
- Kapila, Suman
- Venue
- Microbial Pathogenesis
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 125
- Pages
- 454-462
- ISSN
- 0882-4010 (ISSN-L)
- OpenAlex
- W2896457958
- Semantic Scholar
- 7d71f4a00180e9549271384bfaf14069245e1258
- Cited by
- 73
- References
- 54
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 18 · 2021: 13 · 2020: 10 · 2019: 8
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Microbial Pathogenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, Lactobacillus rhamnosus, Lactobacillus fermentum, probiotic fermented milk, type 1 diabetes, streptozotocin-induced diabetes, glucose metabolism, HbA1c, insulin, inflammation, oxidative stress, lipid profile, gluconeogenesis, phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, antidiabetic activity
- MeSH terms
- Animals, Blood Chemical Analysis, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Diet Therapy, Disease Models, Animal, Fermentation, Kidney, Liver, Milk, Treatment Outcome, Rats, Wistar, Limosilactobacillus fermentum, Lacticaseibacillus rhamnosus
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