Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers: A Randomized Controlled Single-Blind Pilot Study
Abstract
This study investigated the effect of 6-week supplementation of a probiotic strain Lactobacillus salivarius UBL S22 with or without prebiotic fructo-oligosaccharide (FOS) on serum lipid profiles, immune responses, insulin sensitivity, and gut lactobacilli in 45 healthy young individuals. The patients were divided into 3 groups (15/group), that is, placebo, probiotic, and synbiotic. After 6 weeks, a significant reduction (P < .05) in total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides and increase in high-density lipoprotein cholesterol was observed in the probiotic as well as in the synbiotic group when compared to placebo; however, the results of total cholesterol and LDL-cholesterol were more pronounced in the synbiotic group. Similarly, when compared to the placebo group, the serum concentrations of inflammatory markers such as high sensitivity C-reactive protein, interleukin (IL) 6, IL-1β, and tumor necrosis factor α were significantly (P < .05) reduced in both the experimental groups, but again the reduction in the synbiotic group was more pronounced. Also, an increase (P < .05) in the fecal counts of total lactobacilli and a decrease (P < .05) in coliforms and Escherichia coli was observed in both the experimental groups after 6 weeks of ingestion. Overall, the combination of L salivarius with FOS was observed to be more beneficial than L salivarius alone, thereby advocating that such synbiotic combinations could be therapeutically exploited for improved health and quality of life.
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A clinical study showed that the probiotic Lactobacillus salivarius decreased inflammatory markers in healthy subjects, and its effect when combined with FOS was more pronounced.
“A clinical study showed that the probiotic Lactobacillus salivarius decreased inflammatory markers in healthy subjects, and its effect when combined with FOS was more pronounced (Rajkumar et al., 2015).”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Rajkumar et al., 2015
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- Authors
- Rajkumar, H., Kumar, M., Das, N., Kumar, S. N., Challa, H. R., & Nagpal, R.
- Affiliations
- National Institute of Nutrition (IN)
- Juntendo University (JP)
- Corresponding author
- Kumar, Manoj
- Venue
- Journal of Cardiovascular Pharmacology and Therapeutics
- Publisher
- SAGE Publications
- Published
- 2014-10-20
- Volume
- 20
- Issue
- 3
- Pages
- 289-298
- ISSN
- 1074-2484 (ISSN-L)
- 1940-4034
- OpenAlex
- W2133938010
- Cited by
- 128
- References
- 66
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 14 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 12 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 7
- FWCI
- 12.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Pharmacology and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus salivarius, fructooligosaccharides, synbiotic supplementation, lipid profile, LDL cholesterol, triglycerides, HDL cholesterol, total cholesterol, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, insulin sensitivity, fecal coliforms, Escherichia coli, healthy young adults
- MeSH terms
- Gastrointestinal Microbiome, Adult, C-Reactive Protein, Humans, Insulin Resistance, Lactobacillus, Lipids, Oligosaccharides, Tumor Necrosis Factor-alpha, Volunteers, Interleukin-6, Single-Blind Method, Probiotics, Prebiotics
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