Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo
Open accessAbstract
Alumosilicate materials zeolites are widely exploited due to porous structure and ion-exchange properties in several industrial, agriculture and veterinary applications. The mainly used zeolite for medical purposes in animals and humans is the natural zeolite clinoptilolite. Clinoptilolite may be prepared for medical applications by different methods that are usually based on mechanical or tribomechanical processing that increase specific surface area. Different processing procedures are known to cause substantial changes in the physical-chemical properties of the material that may affect biological properties as well. In this paper we therefore, (1) systematically analysed physical-chemical characteristics of three clinoptilolite materials obtained by different production methods and one synthetic zeolite to provide novel evidence on structural differences caused by production methods and (2) evaluated clinoptilolite materials detoxification properties in vitro and in AlCl3 - intoxicated rats in vivo. We analysed a new clinoptilolite material as well, that was prepared by tribomechanical double micronization and oxygenation. Our results clearly show that each tested clinoptilolite material differs in physical-chemical properties and that these are linked to the production method. Our results add knowledge on toxicology and safety properties of clinoptilolite materials as no aluminium leakage was observed from clinoptilolite materials into the blood or organs of tested animals. Presented results therefore, prove for the first time the efficiency of clinoptilolite in detoxification of aluminium in vivo, provide scientific data on clinoptilolite safety issues and usage for detoxification purposes.
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No aluminum leakage into the blood or organs of tested animals was demonstrated, proving the efficiency of clinoptilolite in the detoxification of aluminum in vivo.
“The results demonstrated no aluminum leakage of these materials into the blood or organs of tested animals, proving for the first time the efficiency of clinoptilolite in the detoxification of aluminum in vivo, and providing scientific data on safety issues and usage for detoxification purposes.”
From Fundamental properties and sustainable applications of the natural zeolite clinoptilolite (2024) · cites this paper as Kraljević Pavelić et al. 2017
Different clinoptilolite processing procedures may cause substantial changes in the physical-chemical properties of the material, affecting biological properties as well.
“different clinoptilolite processing procedures may cause substantial changes in the physical-chemical properties of the material, affecting biological properties as well.”
From Fundamental properties and sustainable applications of the natural zeolite clinoptilolite (2024) · cites this paper as Kraljević Pavelić et al. 2017
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- Authors
- Kraljević Pavelić, S., Micek, V., Filošević, A., Gumbarević, D., Žurga, P., Bulog, A., Orct, T., Yamamoto, Y., Preočanin, T., Plavec, J., Peter, R., Petravić, M., Vikić-Topić, D., & Pavelić, K.
- Affiliations
- Institute for Medical Research and Occupational Health (HR)
- University of Rijeka (HR)
- JEOL (Japan) (JP)
- University of Zagreb (HR)
- National Institute of Chemistry (SI)
- ORCID
- Venue
- Microporous and Mesoporous Materials
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 249
- Pages
- 146-156
- ISSN
- 1387-1811 (ISSN-L)
- OpenAlex
- W2610385708
- Cited by
- 40
- References
- 47
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Microporous and Mesoporous Materials (publishedVersion, cc-by-nc-nd)
- Funders
- Panaceo International Active Mineral Production GmbH
- University of Rijeka (13.11.1.1.11, 13.11.1.2.01)
- European Regional Development FundEuropean Regional Development Fund (ERDF)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Zeolite Catalysis and Synthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Health Professions › Complementary and Manual Therapy › Therapeutic Uses of Natural Elements
- Keywords
- clinoptilolite, aluminum detoxification, zeolites, oxygenation, rats
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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