Cited by 39Nanoparticle-Based Drug DeliveryCell death mechanisms and regulationDrug Transport and Resistance Mechanisms

In Vitro assessment of the utility of stearyl triphenyl phosphonium modified liposomes in overcoming the resistance of ovarian carcinoma Ovcar-3 cells to paclitaxel

Solomon, Melani A., Shah, Anee A., D'Souza, Gerard G.M.·2013·Mitochondrion

Abstract

Paclitaxel loaded in liposomes modified with stearyl triphenyl phosphonium (STPP) showed improved mitochondrial colocalization and cytotoxicity in a paclitaxel resistant cell line. The improvement in cytotoxicity was not solely due to the increased accumulation of paclitaxel in mitochondria but also due to the specific toxicity of STPP towards the resistant cell line. Mechanistic studies revealed that the cytotoxicity of STPP was associated with a decrease in mitochondrial membrane potential and other hallmarks related to caspase-independent cell death (CICD). This specific toxicity of STPP towards the paclitaxel resistant cell line was also maintained in three-dimensional in vitro spheroid cultures.

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Crossref · 10.1016/j.mito.2012.10.013

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Authors
Solomon, M. A., Shah, A. A., & D'Souza, G. G. M.
Affiliations
Massachusetts College of Pharmacy and Health Sciences (US)
Venue
Mitochondrion
Publisher
Elsevier BV
Published
2013-09
Volume
13
Issue
5
Pages
464-472
ISSN
1567-7249 (ISSN-L)
OpenAlex
W2003335129
Cited by
39
References
46
Citations by year
2026: 1 · 2025: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4
FWCI
1.56
Type
journal article
Language
en
Open access
closed
Locations
  • Mitochondrion (publishedVersion)
  • PubMed (publishedVersion)
Funders
MCPHS Faculty Development Committee
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
liposomes, paclitaxel resistance, ovarian carcinoma, OVCAR-3 cells, mitochondrial colocalization, mitochondrial membrane potential, caspase-independent cell death, liposomal drug delivery, three-dimensional spheroid culture, cytotoxicity
MeSH terms
Antineoplastic Agents, Cell Survival, Drug Carriers, Female, Humans, Liposomes, Mitochondria, Cell Death, Paclitaxel, Cell Line, Tumor, Membrane Potential, Mitochondrial

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