Cited by 128GDF15 and Related BiomarkersMitochondrial Function and PathologyMetabolism and Genetic Disorders

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

Fujita, Yasunori, Ito, Masafumi, Kojima, Toshio, Yatsuga, Shuichi, Koga, Yasutoshi, Tanaka, Masashi·2015·Mitochondrion

Abstract

Pyruvate therapy is a promising approach for the treatment of mitochondrial diseases. To identify novel biomarkers for diagnosis and to evaluate therapeutic efficacy, we performed microarray analysis of 2SD cybrid cells harboring a MELAS-causing mutation and control cells treated with either lactate or pyruvate. We found that expression and secretion of growth differentiation factor 15 (GDF15) were increased in 2SD cells treated with lactate and that serum GDF15 levels were significantly higher in patients with mitochondrial diseases than in those with other diseases, suggesting that GDF15 could be a useful marker for diagnosis and evaluating the therapeutic efficacy of pyruvate.

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Crossref · 10.1016/j.mito.2014.10.006

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Authors
Fujita, Y., Ito, M., Kojima, T., Yatsuga, S., Koga, Y., & Tanaka, M.
Affiliations
  • Tokyo Metropolitan Institute of Gerontology (JP)
  • Toyohashi University of Technology (JP)
  • Kurume University (JP)
Corresponding author
Tanaka, Masashi
Venue
Mitochondrion
Publisher
Elsevier BV
Published
2015-01
Volume
20
Pages
34-42
ISSN
1567-7249 (ISSN-L)
OpenAlex
W2009909106
Cited by
128
References
43
Citations by year
2026: 6 · 2025: 6 · 2024: 13 · 2023: 15 · 2022: 13 · 2021: 11 · 2020: 17 · 2019: 13 · 2018: 13 · 2017: 5 · 2016: 12 · 2015: 4
FWCI
5.80
Type
journal article
Language
en
Open access
closed
Locations
  • Mitochondrion (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Takeda Science Foundation
  • Ministry of Education, Culture, Sports, Science and Technology (A-22240072, A-25242062, B-21390459, C-21590411, C-25461571, C-26350922, C-26670481, CER-24650414, YSB-25860891)
  • Ministry of Health, Labour and Welfare (23-Nanchi-Ippan-016, 23-Nanchi-Ippan-116, 24-Nanchi-Ippan-005)
Topics
  • Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
GDF15, growth differentiation factor 15, mitochondrial disease, MELAS, biomarkers, treatment efficacy, serum biomarkers, lactate, microarray gene expression
MeSH terms
Humans, Biomarkers, Drug Monitoring, Pyruvic Acid, Gene Expression Profiling, Mitochondrial Diseases, Microarray Analysis, Growth Differentiation Factor 15

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