GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases
Abstract
Pyruvate therapy is a promising approach for the treatment of mitochondrial diseases. To identify novel biomarkers for diagnosis and to evaluate therapeutic efficacy, we performed microarray analysis of 2SD cybrid cells harboring a MELAS-causing mutation and control cells treated with either lactate or pyruvate. We found that expression and secretion of growth differentiation factor 15 (GDF15) were increased in 2SD cells treated with lactate and that serum GDF15 levels were significantly higher in patients with mitochondrial diseases than in those with other diseases, suggesting that GDF15 could be a useful marker for diagnosis and evaluating the therapeutic efficacy of pyruvate.
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FGF21 and GDF15 are synthesized in response to mitochondrial stress.
“a number of molecules that are synthesized in response to mitochondrial stress have been identified, including FGF21 (10) and GDF15 (15).”
From Human Aging and Longevity Are Characterized by High Levels of Mitokines (2019) · cites this paper as [15]
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- Authors
- Fujita, Y., Ito, M., Kojima, T., Yatsuga, S., Koga, Y., & Tanaka, M.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- Toyohashi University of Technology (JP)
- Kurume University (JP)
- Corresponding author
- Tanaka, Masashi
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 20
- Pages
- 34-42
- ISSN
- 1567-7249 (ISSN-L)
- OpenAlex
- W2009909106
- Cited by
- 128
- References
- 43
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 13 · 2023: 15 · 2022: 13 · 2021: 11 · 2020: 17 · 2019: 13 · 2018: 13 · 2017: 5 · 2016: 12 · 2015: 4
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mitochondrion (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Takeda Science Foundation
- Ministry of Education, Culture, Sports, Science and Technology (A-22240072, A-25242062, B-21390459, C-21590411, C-25461571, C-26350922, C-26670481, CER-24650414, YSB-25860891)
- Ministry of Health, Labour and Welfare (23-Nanchi-Ippan-016, 23-Nanchi-Ippan-116, 24-Nanchi-Ippan-005)
- Topics
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- GDF15, growth differentiation factor 15, mitochondrial disease, MELAS, biomarkers, treatment efficacy, serum biomarkers, lactate, microarray gene expression
- MeSH terms
- Humans, Biomarkers, Drug Monitoring, Pyruvic Acid, Gene Expression Profiling, Mitochondrial Diseases, Microarray Analysis, Growth Differentiation Factor 15
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