CoChat
Sign Up
Cited by 121

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Tissue specific differences in mitochondrial DNA maintenance and expression

Herbers, Elena, Kekäläinen, Nina J., Hangas, Anu, Pohjoismäki, Jaakko L., Goffart, Steffi·2019·Mitochondrion
DOI 10.1016/j.mito.2018.01.004
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.mito.2018.01.004

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Quality and quantity of mtDNA is closely linked to mitochondrial function.

    “Quality and quantity of mtDNA is closely linked to mitochondrial function [9,10]”

    From The Mitochondrial Genome in Aging and Disease and the Future of Mitochondrial Therapeutics (2022) · cites this paper as [10]

    The Abstract says mtDNA is essential for mitochondrial oxidative phosphorylation, and the Concluding Remarks link failures of genome integrity to possible disease effects. But the manuscript explicitly says the relevance of mtDNA levels to mitochondrial function is unclear, so it does not support the claim that mtDNA quantity is closely linked to function. Page numbers are unavailable in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 51

  1. Alston, 2017, The genetics and pathology of mitochondrial disease, J. Pathol., 241, 236, 10.1002/path.4809 · DOI
  2. Ciesielski, 2016, Animal mitochondrial DNA replication, The Enzymes, 39, 255, 10.1016/bs.enz.2016.03.006 · DOI
  3. Crews, 1979, Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication, Nature, 277, 192, 10.1038/277192a0 · DOI
  4. Falkenberg, 2007, DNA replication and transcription in mammalian mitochondria, Annu. Rev. Biochem., 76, 679, 10.1146/annurev.biochem.76.060305.152028 · DOI
  5. Fernandez-Vizarra, 2011, Tissue-specific differences in mitochondrial activity and biogenesis, Mitochondrion, 11, 207, 10.1016/j.mito.2010.09.011 · DOI
  6. Fish, 2004, Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis, Science, 306, 2098, 10.1126/science.1102077 · DOI
  7. Fukuoh, 2009, DNA conformation-dependent activities of human mitochondrial RNA polymerase, Genes Cells, 14, 1029, 10.1111/j.1365-2443.2009.01328.x · DOI
  8. Fuste, 2010, Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication, Mol. Cell, 37, 67, 10.1016/j.molcel.2009.12.021 · DOI
  9. Goffart, 2009, Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling, Hum. Mol. Genet., 18, 328, 10.1093/hmg/ddn359 · DOI · Paper page
  10. Gong, 2016, Evaluation of candidate reference genes for RT-qPCR studies in three metabolism related tissues of mice after caloric restriction, Sci. Rep., 6
  11. Han, 2015, Deceleration of liver regeneration by knockdown of augmenter of liver regeneration gene is associated with impairment of mitochondrial DNA synthesis in mice, Am. J. Physiol. Gastrointest. Liver Physiol., 309, G112, 10.1152/ajpgi.00435.2014 · DOI
  12. Herrero-Mendez, 2009, The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1, Nat. Cell Biol., 11, 747, 10.1038/ncb1881 · DOI · Paper page
  13. Jayashankar, 2016, Shaping the multi-scale architecture of mitochondria, Curr. Opin. Cell Biol., 38, 45, 10.1016/j.ceb.2016.02.006 · DOI
  14. Johnson, 2007, Functional consequences of mitochondrial proteome heterogeneity, Am. J. Phys. Cell Phys., 292, C698, 10.1152/ajpcell.00109.2006 · DOI
  15. Johnson, 2007, Tissue heterogeneity of the mammalian mitochondrial proteome, Am. J. Phys. Cell Phys., 292, C689, 10.1152/ajpcell.00108.2006 · DOI
  16. Kanki, 2004, Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA, Mol. Cell. Biol., 24, 9823, 10.1128/MCB.24.22.9823-9834.2004 · DOI
  17. Kolesar, 2013, Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome, Nucleic Acids Res., 41, 10.1093/nar/gks1324 · DOI
  18. Korhonen, 2004, Reconstitution of a minimal mtDNA replisome in vitro, EMBO J., 23, 2423, 10.1038/sj.emboj.7600257 · DOI
  19. Kukat, 2015, Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid, Proc. Natl. Acad. Sci. U. S. A., 112, 11288, 10.1073/pnas.1512131112 · DOI
  20. Kunz, 2003, Different metabolic properties of mitochondrial oxidative phosphorylation in different cell types—important implications for mitochondrial cytopathies, Exp. Physiol., 88, 149, 10.1113/eph8802512 · DOI
  21. Lehle, 2014, LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis, Nucleic Acids Res., 42, 10.1093/nar/gkt1349 · DOI
  22. Lopez-Fabuel, 2016, Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes, Proc. Natl. Acad. Sci. U. S. A., 113, 13063, 10.1073/pnas.1613701113 · DOI
  23. Matsushima, 2010, Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM), Proc. Natl. Acad. Sci. U. S. A., 107, 18410, 10.1073/pnas.1008924107 · DOI
  24. Miralles Fuste, 2014, In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication, PLoS Genet., 10, 10.1371/journal.pgen.1004832 · DOI
  25. Mruk, 2011, Enhanced chemiluminescence (ECL) for routine immunoblotting: an inexpensive alternative to commercially available kits, Spermatogenesis, 1, 121, 10.4161/spmg.1.2.16606 · DOI
  26. Neuhaus, 2014, Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons, Brain, 137, 354, 10.1093/brain/awt291 · DOI
  27. Neuhaus, 2017, Catecholamine metabolism induces mitochondrial DNA deletions and leads to severe adrenal degeneration during aging, Neuroendocrinology, 104, 72, 10.1159/000444680 · DOI
  28. Pham, 2006, Conserved sequence box II directs transcription termination and primer formation in mitochondria, J. Biol. Chem., 281, 24647, 10.1074/jbc.M602429200 · DOI
  29. Pohjoismaki, 2012, Letter by Pohjoismaki regarding article, “Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease”, Circ. Heart Fail., 5, e15, 10.1161/CIRCHEARTFAILURE.111.964502 · DOI
  30. Pohjoismaki, 2011, Of circles, forks and humanity: topological organisation and replication of mammalian mitochondrial DNA, BioEssays, 33, 290, 10.1002/bies.201000137 · DOI
  31. Pohjoismaki, 2017, The role of mitochondria in cardiac development and protection, Free Radic. Biol. Med., 106, 345, 10.1016/j.freeradbiomed.2017.02.032 · DOI
  32. Pohjoismaki, 2006, Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells, Nucleic Acids Res., 34, 5815, 10.1093/nar/gkl703 · DOI
  33. Pohjoismaki, 2010, Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid, J. Mol. Biol., 397, 1144, 10.1016/j.jmb.2010.02.029 · DOI
  34. Pohjoismaki, 2012, Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response, Nucleic Acids Res., 40, 6595, 10.1093/nar/gks301 · DOI
  35. Pohjoismaki, 2013, Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes, Mol. BioSyst., 9, 1210, 10.1039/c3mb25556e · DOI
  36. Reyes, 2013, Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts, Nucleic Acids Res., 41, 5837, 10.1093/nar/gkt196 · DOI
  37. Rinkevich, 2014, In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration, Cell Rep., 7, 1270, 10.1016/j.celrep.2014.04.018 · DOI
  38. Rubio-Cosials, 2011, Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter, Nat. Struct. Mol. Biol., 18, 1281, 10.1038/nsmb.2160 · DOI
  39. Ruhanen, 2010, Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation, Biochim. Biophys. Acta, 1803, 931, 10.1016/j.bbamcr.2010.04.008 · DOI
  40. Scarpulla, 2008, Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator, Ann. N. Y. Acad. Sci., 1147, 321, 10.1196/annals.1427.006 · DOI
  41. Schrepfer, 2016, Mitofusins, from mitochondria to metabolism, Mol. Cell, 61, 683, 10.1016/j.molcel.2016.02.022 · DOI
  42. Sen, 2012, Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase, J. Biol. Chem., 287, 14545, 10.1074/jbc.M111.309468 · DOI · Paper page
  43. Sen, 2016, Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE, Nucleic Acids Res., 44, 4200, 10.1093/nar/gkw098 · DOI
  44. Shi, 2012, Mammalian transcription factor A is a core component of the mitochondrial transcription machinery, Proc. Natl. Acad. Sci. U. S. A., 109, 16510, 10.1073/pnas.1119738109 · DOI
  45. Stefanatos, 2017, The role of mitochondrial ROS in the aging brain, FEBS Lett.
  46. Svingen, 2015, Selection of reference genes for quantitative RT-PCR (RT-qPCR) analysis of rat tissues under physiological and toxicological conditions, PeerJ, 3, 10.7717/peerj.855 · DOI
  47. Torregrosa-Munumer, 2017, PrimPol is required for replication reinitiation after mtDNA damage, Proc. Natl. Acad. Sci. U. S. A., 114, 11398, 10.1073/pnas.1705367114 · DOI
  48. Voos, 2016, Protein quality control at the mitochondrion, Essays Biochem., 60, 213, 10.1042/EBC20160009 · DOI
  49. Wanrooij, 2007, Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes, Nucleic Acids Res., 35, 3238, 10.1093/nar/gkm215 · DOI · Paper page
  50. Wanrooij, 2008, Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro, Proc. Natl. Acad. Sci. U. S. A., 105, 11122, 10.1073/pnas.0805399105 · DOI
  51. Yasukawa, 2006, Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand, EMBO J., 25, 5358, 10.1038/sj.emboj.7601392 · DOI

Cited by

Sorted by citations

Metadata

Authors
Herbers, E., Kekäläinen, N. J., Hangas, A., Pohjoismäki, J. L., & Goffart, S.
ORCID
Goffart, Steffi
Venue
Mitochondrion
Publisher
Elsevier BV
Published
2019-01
Volume
44
Pages
85-92
ISSN
1567-7249
DOI
10.1016/j.mito.2018.01.004
Cited by
121
References
6
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Academy of Finland (292822, 265314)
  • Finnish Cultural Foundation, North Carelia Regional (55172179)
  • Jane and Aatos Erkko Foundation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review