Overexpression of twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species

The Free Radical Theory of Aging Matures

BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

High density synthetic oligonucleotide arrays

Lipshutz, R. J., Fodor, S. P. A., Gingeras, T., & Lockhart, D. J. (1999) · Nature Genetics · doi:10.1038/4447 · Cited by 2,204 · see citing works

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works

Detection of ultra-rare mutations by next-generation sequencing

Schmitt, M. W., Kennedy, S. R., Salk, J. J., Fox, E. J., Hiatt, J. B., & Loeb, L. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208715109 · Cited by 1,047 · see citing works

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works

Somatic Mitochondrial DNA Mutations in Mammalian Aging

Larsson, N. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060408-093701 · Cited by 543 · see citing works

Generation of superoxide by the mitochondrial Complex I

Grivennikova, V. G., & Vinogradov, A. D. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.013 · Cited by 379 · see citing works

Isolation and Culture of Adult Mouse Cardiac Myocytes

O’Connell, T. D., Rodrigo, M. C., & Simpson, P. C. (2006) · Humana Press eBooks · doi:10.1385/1-59745-214-9:271 · Cited by 341 · see citing works

Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks

Branzei, D., Sollier, J., Liberi, G., Zhao, X., Maeda, D., Seki, M., Enomoto, T., Ohta, K., & Foiani, M. (2006) · Cell · doi:10.1016/j.cell.2006.08.050 · Cited by 291 · see citing works

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number

Tyynismaa, H., Sembongi, H., Bokori-Brown, M., Granycome, C., Ashley, N., Poulton, J., Jalanko, A., Spelbrink, J. N., Holt, I. J., & Suomalainen, A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh342 · Cited by 250 · see citing works

Knockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis

Remmen, H. V., Williams, M. D., Guo, Z., Estlack, L. E., Yang, H. C., Carlson, E. J., Epstein, C. J., Huang, T., & Richardson, A. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1422 · Cited by 230 · see citing works

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

Ameur, A., Stewart, J. B., Freyer, C., Hagström, E., Ingman, M., Larsson, N., & Gyllensten, U. B. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002028 · Cited by 202 · see citing works

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

Raimundo, N., Song, L., Shutt, T. E., McKay, S. E., Cotney, J. L., Guan, M., Gilliland, T., Hohuan, D., Santos‐Sacchi, J., & Shadel, G. S. (2012) · Cell · doi:10.1016/j.cell.2011.12.027 · Cited by 189 · see citing works

The mitochondrial theory of aging: Insight from transgenic and knockout mouse models

Jang, Y. C., & Remmen, H. V. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.12.006 · Cited by 183 · see citing works

Regulation of mitochondrial proliferation in the heart: power-plant failure contributes to cardiac failure in hypertrophy

Goffart, S., VONKLEISTRETZOW, J., & Wiesner, R. H. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.06.030 · Cited by 176 · see citing works

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

Pohjoismäki, J., Wanrooij, S., Hyvärinen, A. K., Goffart, S., Holt, I. J., Spelbrink, J. N., & Jacobs, H. T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl703 · Cited by 168 · see citing works

Widespread Recombination in Published Animal mtDNA Sequences1

Tsaousis, A. D., Martin, D. P., Ladoukakis, E. D., Posada, D., & Zouros, E. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi084 · Cited by 168 · see citing works

DNA repair in mammalian mitochondria: Much more than we thought?

Liu, P., & Demple, B. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20576 · Cited by 159 · see citing works

Expression of catalytic mutants of the mtDNA helicase twinkle and polymerase POLG causes distinct replication stalling phenotypes

Wanrooij, S., Goffart, S., Pohjoismäki, J. L. O., Yasukawa, T., & Spelbrink, J. N. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm215 · Cited by 148 · see citing works

High mitochondrial DNA copy number has detrimental effects in mice

Ylikallio, E., Tyynismaa, H., Tsutsui, H., Ide, T., & Suomalainen, A. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq163 · Cited by 137 · see citing works

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

Remmen, H. V., Qi, W., Sabia, M., Freeman, G. L., Estlack, L. E., Yang, H. C., Guo, Z. M., Huang, T., Strong, R., Lee, S., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.016 · Cited by 130 · see citing works

Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication

Hori, A., Yoshida, M., Shibata, T., & Ling, F. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn993 · Cited by 129 · see citing works

Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch

Vanoli, F., Fumasoni, M., Szakál, B., Maloisel, L., & Branzei, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001205 · Cited by 127 · see citing works

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks

Pohjoismäki, J. L. O., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P. J., Griffith, J. D., Holt, I. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016600 · Cited by 122 · see citing works

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

Bailey, L. J., Cluett, T. J., Reyes, A., Prolla, T. A., Poulton, J., Leeuwenburgh, C., & Holt, I. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp091 · Cited by 107 · see citing works

The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers

Williams, S. L., Huang, J., Edwards, Y. J. K., Ulloa, R. H., Dillon, L. M., Prolla, T. A., Vance, J. M., Moraes, C. T., & Zuchner, S. L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.012 · Cited by 99 · see citing works

Sustained Persistence of Transplanted Proangiogenic Cells Contributes to Neovascularization and Cardiac Function After Ischemia

Ziebart, T., Yoon, C., Trepels, T., Wietelmann, A., Braun, T. W., Kiessling, F. M., Stein, S., Grez, M., Ihling, C. H., Muhly-Reinholz, M., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.180463 · Cited by 99 · see citing works

Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse

Dillon, L. M., Williams, S. L., Hida, A., Peacock, J. D., Prolla, T. A., Lincoln, J., & Moraes, C. T. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds049 · Cited by 98 · see citing works

Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents

Kienhöfer, J., Haeussler, D. J., Ruckelshausen, F., Muessig, E., Weber, K., Pimentel, D. R., Ullrich, V., Bürkle, A., & Bachschmid, M. M. (2009) · The FASEB Journal · doi:10.1096/fj.08-113571 · Cited by 80 · see citing works

Mitochondrial complex I: A central regulator of the aging process

Stefanatos, R. K. A., & Sanz, A. (2011) · Cell Cycle · doi:10.4161/cc.10.10.15496 · Cited by 77 · see citing works

Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA

Pohjoismäki, J., & Goffart, S. (2011) · BioEssays · doi:10.1002/bies.201000137 · Cited by 71 · see citing works

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response

Pohjoismäki, J., Boettger, T., Liu, Z., Goffart, S., Szibor, M., & Braun, T. W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks301 · Cited by 65 · see citing works

Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage

Mankouri, H. W., Ashton, T. M., & Hickson, I. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1014240108 · Cited by 64 · see citing works

Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase

Sen, D., Nandakumar, D., Tang, G.-Q., & Patel, S. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.309468 · Cited by 63 · see citing works

Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome

Kolesar, J. E., Wang, C. Y., Taguchi, Y. V., Chou, S.-H., & Kaufman, B. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1324 · Cited by 62 · see citing works

Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice

Loch, T., Vakhrusheva, O., Piotrowska, I., Ziółkowski, W., Ebelt, H., Braun, T. W., & Bober, E. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp092 · Cited by 55 · see citing works

Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals

Erol, A. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.11.023 · Cited by 53 · see citing works

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number

Pohjoismäki, J. L. O., Goffart, S., Taylor, R. W., Turnbull, D. M., Suomalainen, A., Jacobs, H. T., & Karhunen, P. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010426 · Cited by 50 · see citing works

Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes

Pohjoismäki, J., Krüger, M., Al-Furoukh, N., Lagerstedt, A., Karhunen, P. J., & Braun, T. W. (2013) · Molecular BioSystems · doi:10.1039/c3mb25556e · Cited by 38 · see citing works

The Phage T4 Protein UvsW Drives Holliday Junction Branch Migration

Webb, M. R., Plank, J. L., Long, D. T., Hsieh, T., & Kreuzer, K. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705913200 · Cited by 34 · see citing works

The overexpression of twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice

Tanaka, A., Ide, T., Fujino, T., Onitsuka, K., Ikeda, M., Takehara, T., Hata, Y., Ylikallio, E., Tyynismaa, H., Suomalainen, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067642 · Cited by 23 · see citing works

Unique mode of cell death in freshly isolated adult rat ventricular cardiomyocytes exposed to hydrogen peroxide

Goto, K., Takemura, G., Maruyama, R., Nakagawa, M., Tsujimoto, A., Kanamori, H., Li, L., Kawamura, I., Kawaguchi, T., Takeyama, T., et al. (2009) · Medical Molecular Morphology · doi:10.1007/s00795-009-0439-x · Cited by 11 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

Yu, E., Reinhold, J., Yu, H., Starks, L. T., Uryga, A., Foote, K., Finigan, A. J., Figg, N. L., Pung, Y. F., Logan, A., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310042 · Cited by 170 · see citing works

Signaling Pathways in Cardiac Myocyte Apoptosis

Xia, P., Liu, Y., & Cheng, Z. (2016) · BioMed Research International · doi:10.1155/2016/9583268 · Cited by 165 · see citing works

Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress

Ikeda, M., Ide, T., Fujino, T., Arai, S., Saku, K., Kakino, T., Tyynismaa, H., Yamasaki, T., Yamada, K.-I., Kang, D., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0119687 · Cited by 152 · see citing works

Maintaining Ancient Organelles

Vega, R. B., Horton, J. L., & Kelly, D. P. (2015) · Circulation Research · doi:10.1161/circresaha.116.305420 · Cited by 146 · see citing works

The role of mitochondria in cardiac development and protection

Pohjoismäki, J., & Goffart, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.032 · Cited by 145 · see citing works

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

Akhmedov, A. T., Rybin, V. O., & Marı́n-Garcı́a, J. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9457-4 · Cited by 125 · see citing works

Tissue specific differences in mitochondrial DNA maintenance and expression

Herbers, E., Kekäläinen, N. J., Hangas, A., Pohjoismäki, J., & Goffart, S. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.01.004 · Cited by 122 · see citing works

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice

Foote, K., Reinhold, J., Yu, E., Figg, N. L., Finigan, A. J., Murphy, M. P., & Bennett, M. R. (2018) · Aging Cell · doi:10.1111/acel.12773 · Cited by 120 · see citing works

The role of mitochondrial DNA damage in the development of atherosclerosis

Yu, E., & Bennett, M. R. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.011 · Cited by 90 · see citing works

Mitochondrial DNA maintenance: an appraisal

Akhmedov, A. T., & Marı́n-Garcı́a, J. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2532-x · Cited by 83 · see citing works

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Pinto, M., Pickrell, A. M., Wang, X., Bacman, S. R., Yu, A., Hida, A., Dillon, L. M., Morton, P. D., Malek, T. R., Williams, S. L., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.123 · Cited by 55 · see citing works

Mitochondrial DNA repair: a novel therapeutic target for heart failure

Marı́n-Garcı́a, J. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9543-x · Cited by 54 · see citing works

Different faces of mitochondrial DNA mutators

Szczepanowska, K., & Trifunović, A. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.016 · Cited by 44 · see citing works

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

Torregrosa-Muñumer, R., Goffart, S., Haikonen, J. A., & Pohjoismäki, J. L. O. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-06-0390 · Cited by 42 · see citing works

Roles of DNA helicases in the maintenance of genome integrity

Bochman, M. L. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.963429 · Cited by 38 · see citing works

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

Ding, L., & Liu, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160510870 · Cited by 37 · see citing works

Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis

Inoue, T., Ikeda, M., Ide, T., Fujino, T., Matsuo, Y., Arai, S., Saku, K., & Sunagawa, K. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00044.2016 · Cited by 30 · see citing works

Nuclear genome-wide associations with mitochondrial heteroplasmy

Nandakumar, P., Tian, C., O’Connell, J., Hinds, D. A., Paterson, A. D., & Sondheimer, N. (2021) · Science Advances · doi:10.1126/sciadv.abe7520 · Cited by 29 · see citing works

Cell Cycle Proteins as Key Regulators of Postmitotic Cell Death.

Xia, P., Liu, Y., Chen, J., & Cheng, Z. (2019) · Europe PMC (PubMed Central) · Cited by 25 · see citing works

Cellular and population level processes influence the rate, accumulation and observed frequency of inherited and somatic mtDNA mutations

Melvin, R. G., & Ballard, J. W. O. (2017) · Mutagenesis · doi:10.1093/mutage/gex004 · Cited by 23 · see citing works

Replication fork rescue in mammalian mitochondria

Torregrosa‐Muñumer, R., Hangas, A., Goffart, S., Blei, D., Zsurka, G., Griffith, J. D., Kunz, W. S., & Pohjoismäki, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-45244-6 · Cited by 23 · see citing works

Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase

Khan, I., Crouch, J. D., Bharti, S. K., Sommers, J. A., Carney, S. M., Yakubovskaya, E., García–Díaz, M., Trakselis, M. A., & Brosh, R. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712026 · Cited by 23 · see citing works

Known Unknowns of Mammalian Mitochondrial DNA Maintenance

Pohjoismäki, J., Forslund, J. M. E., Goffart, S., Torregrosa‐Muñumer, R., & Wanrooij, S. (2018) · BioEssays · doi:10.1002/bies.201800102 · Cited by 18 · see citing works

Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target

Xiang, M., Yang, M., Zhang, L., Ouyang, X., Sarapultsev, A., Luo, S., & Hu, D. (2025) · Antioxidants · doi:10.3390/antiox14091138 · Cited by 17 · see citing works

Mitochondrial DNA Depletion Syndrome and Its Associated Cardiac Disease

Wang, H., Han, Y., Li, S., Chen, Y., Chen, Y., Wang, J., Zhang, Y., Zhang, Y., Wang, J., Xia, Y., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.808115 · Cited by 16 · see citing works

Mechanistic and biological considerations of oxidatively damaged DNA for helicase-dependent pathways of nucleic acid metabolism

Crouch, J. D., & Brosh, R. M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.022 · Cited by 15 · see citing works

Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation

Landoni, J. C., Erkul, S., Laalo, T., Goffart, S., Kivelä, R., Skube, K., Nieminen, A. I., Wickström, S. A., Stewart, J. B., & Suomalainen, A. (2024) · Nature Communications · doi:10.1038/s41467-024-52164-1 · Cited by 14 · see citing works

Linear DNA-driven recombination in mammalian mitochondria

Fragkoulis, G., Hangas, A., Fekete, Z., Michell, C., Moraes, C. T., Willcox, S., Griffith, J. D., Goffart, S., & Pohjoismäki, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae040 · Cited by 14 · see citing works

Adaptive and Pathological Outcomes of Radiation Stress-Induced Redox Signaling

Pohjoismäki, J., & Goffart, S. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0257 · Cited by 13 · see citing works

Mitochondrial cardiomyopathies: pathogenesis, diagnosis, and treatment

Maack, C., Dudek, J., Bertero, E., Tampakakis, E., & Vernon, H. J. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf491 · Cited by 12 · see citing works

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase

Li, Z., Kaur, P., Lo, C., Chopra, N., Smith, J., Wang, H., & Gao, Y. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1089 · Cited by 12 · see citing works

Comparative response of Spodoptera litura challenged per os with Serratia marcescens strains differing in virulence

Aggarwal, C., Paul, S., Nain, V., Tripathi, V., Paul, B., & Khan, M. A. (2021) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2021.107562 · Cited by 11 · see citing works

Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase

Ciesielski, G. L., Nadalutti, C. A., Oliveira, M. T., Jacobs, H. T., Griffith, J. D., & Kaguni, L. S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky094 · Cited by 11 · see citing works

Age-Dependent Oxidative DNA Damage Does Not Correlate with Reduced Proliferation of Cardiomyocytes in Humans

Huang, Y., Hong, H., Li, M., Liu, J., Jiang, C., Zhang, H., Ye, L., & Zheng, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170351 · Cited by 9 · see citing works

Mutation of TWNK Gene Is One of the Reasons of Runting and Stunting Syndrome Characterized by mtDNA Depletion in Sex-Linked Dwarf Chicken

Hu, B., Yang, M., Liao, Z., Wei, H., Zhao, C., Li, D., Hu, S., Jiang, X., Shi, M., Luo, Q., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00581 · Cited by 4 · see citing works

Thermodynamic analysis of mitochondrial DNA breakpoints reveals mechanistic details of deletion mutagenesisPreprint

Lakshmanan, L. N., Yee, Z., Gruber, J., Halliwell, B. B., & Gunawan, R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/254631 · Cited by 3 · see citing works

Mitochondrial Quality Control in Macrophages During Cardiovascular Disease

Falconer, R., & Day, E. A. (2026) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2026.02.034 · Cited by 2 · see citing works

Human mitochondrial DNA repair

Sia, E. A., & Stein, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819656-4.00008-5 · Cited by 2 · see citing works

Turnover and Quality Control of Mitochondrial DNA

Kunz, W. S. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925602485 · Cited by 1 · see citing works

Human mitochondrial helicase Twinkle has RNA binding, annealing, and strand-exchange activities

Singh, A., Johnson, L. C., Baruch‐Torres, N., Yin, Y. W., & Patel, S. S. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag008 · Cited by 1 · see citing works

Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosisPreprint

Landoni, J. C., Laalo, T., Goffart, S., Kivelä, R., Skube, K., Nieminen, A. I., Wickström, S. A., Stewart, J. B., & Suomalainen, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.04.485133 · Cited by 1 · see citing works

Characterizing Excluded Strand DNA Interactions with Hexameric Helicases and Determining Roles in Unwinding Mechanisms

Carney, S. M. (2016) · D-Scholarship@Pitt (University of Pittsburgh)

Helicases and Their Relevance to Aging

Crouch, J. D., Banerjee, T., Awate, S., Bharti, S. K., & Brosh, R. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00072-5

Thermodynamic analysis of DNA hybridization signatures near mitochondrial DNA deletion breakpoints

Lakshmanan, L. N., Yee, Z., Halliwell, B. B., Gruber, J., & Gunawan, R. (2021) · iScience · doi:10.1016/j.isci.2021.102138

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Koriyama, H., Hironori Nakagami, A., Katsuya, T., Sugimoto, K., Yamashita, H., Takami, Y., Mori, M., Hayashi, H., Rakugi, H., Morishita, R., et al. (2008) · Japanese Circulation Journal-english Edition

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