Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,231

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · cited 2×

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327

DNA damage activates p53 through a phosphorylation–acetylation cascade

Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162

CHFR negatively regulates SIRT1 activity upon oxidative stress

Kim, M., Kwon, Y. E., Song, J. O., Bae, S. J., & Seol, J. H. (2016) · Scientific Reports · doi:10.1038/srep37578 · Cited by 24

CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53

Taniguchi, H., Ito, S., Ueda, T., Morioka, Y., Kayukawa, N., Ueno, A., Nakagawa, H., Fujihara, A., Ushijima, S., Kanazawa, M., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.095 · Cited by 24

Structure and function of histone acetyltransferase MOF

Chen, Q. Y., Costa, M., & Sun, H. (2015) · AIMS Biophysics · doi:10.3934/biophy.2015.4.555 · Cited by 28

Differential regulation of p53 target genes: it's (core promoter) elementary: Figure 1.Preprint

Gomes, N. P., & Espinosa, J. M. (2010) · Genes & Development · doi:10.1101/gad.1893610 · Cited by 24

SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury

Yu, T., Ding, C., Peng, J., Liang, G., Tang, Y., Zhao, J., & Li, Z. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07549-5 · Cited by 24

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell

Ashraf, W., Bronner, C., Zaayter, L., Ahmad, T., Richert, L., Alhosin, M., Ibrahim, A., Hamiche, A., Mély, Y., & Mousli, M. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0659-1 · Cited by 23

The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation

Chen, J., Liu, D., Chen, B., Yang, Y., Zhu, H., Li, D., Liu, K., Zhu, L., Liu, H., Li, M., et al. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03791-5 · Cited by 23

Model Hirano Bodies Protect against Tau-Independent and Tau-Dependent Cell Death Initiated by the Amyloid Precursor Protein Intracellular Domain

Furgerson, M., Fechheimer, M., & Furukawa, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044996 · Cited by 23

hMOF, a KAT(8) with Many Lives

Mellert, H. S., & McMahon, S. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.005 · Cited by 23

In vitro ischemia decreases histone H4K16 acetylation in neural cells

Dmitriev, R. I., & Papkovsky, D. B. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.11.038 · Cited by 24

Mechanistic Links Between ATM and Histone Methylation Codes During DNA Repair

Xu, Y., Xu, C., & Price, B. D. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00010-9 · Cited by 23

Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin

Lin, Y., & Wang, F.-F. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.017 · Cited by 26

K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay

Lee, S.-Y., Park, J., Jeong, S., Kim, B., Kang, Y., Xu, Y., & Chung, S. (2018) · Oncogene · doi:10.1038/s41388-018-0542-3 · Cited by 22

Histone acetyltransferase promotes fluoride toxicity in LS8 cells

Deng, H., Fujiwara, N., Cui, H., Whitford, G. M., Bartlett, J. D., & Suzuki, M. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.125825 · Cited by 22

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

Lees, A., McIntyre, A. J., Crawford, N., Falcone, F., McCann, C. K., Holohan, C., Quinn, G. P., Roberts, J. Z., Sessler, T., Gallagher, P. F., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001520117 · Cited by 22

ING Proteins: Tumour Suppressors or Oncoproteins

Jacquet, K., & Binda, O. (2021) · Cancers · doi:10.3390/cancers13092110 · Cited by 22

p53 Immunohistochemistry Patterns Are Surrogate Biomarkers for TP53 Mutations in Gastrointestinal Neuroendocrine Neoplasms

Li, J., Wang, J., Su, D., Nie, X., Liu, Y., Teng, L., Pang, J., Wu, H., & Liang, Z. (2021) · Gastroenterology Research and Practice · doi:10.1155/2021/2510195 · Cited by 22

PDCD5-Regulated Cell Fate Decision after Ultraviolet-Irradiation-Induced DNA Damage

Zhuge, C., Chang, Y., Li, Y., Chen, Y., & Lei, J. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.10.044 · Cited by 22

Plasmodium falciparumRuvB proteins

Ahmad, M., & Tuteja, R. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.20005 · Cited by 22

Regulation of Tip60‐dependent p53 acetylation in cell fate decision

Wang, P., Bao, H., Zhang, X., Liu, F., & Wang, W. (2018) · FEBS Letters · doi:10.1002/1873-3468.13287 · Cited by 21

Soft-shell clam (Mya arenaria) p53: A structural and functional comparison to human p53

Holbrook, L. A. C., Butler, R. A., Cashon, R. E., & Beneden, R. J. V. (2008) · Gene · doi:10.1016/j.gene.2008.11.029 · Cited by 22

Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage

Liu, J., Yang, B., Zhou, P., Kong, Y., Hu, W., Zhu, G., Ying, W., Li, W., Wang, Y., & Li, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-07343-0 · Cited by 21

HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation

Park, S.-Y., Phorl, S., Jung, S., Korm, S., Lee, S.-I., Noh, S., Han, M., Naskar, R., Kim, J., Choi, Y., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.087 · Cited by 21

CDK9‐mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery

Brauns‐Schubert, P., Schubert, F., Wissler, M., Weiß, M., Schlicher, L., Bessler, S., Safavi, M., Miething, C., Borner, C., Brummer, T., et al. (2018) · EMBO Reports · doi:10.15252/embr.201744311 · Cited by 20

Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway

Li, H., Lu, M., Zhang, H., Wang, S., Wang, F., Ma, X., Liu, J., Li, X., Yang, H., Shen, H., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04774-0 · Cited by 20

Global Effect of Inauhzin on Human p53-Responsive Transcriptome

Liao, J., Zeng, S. X., Zhou, X. Y., & Lu, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052172 · Cited by 20

The human T-cell leukemia virus type-1 p30II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis

Romeo, M., Hutchison, T., Malu, A., White, A., Kim, J., Gardner, R., Smith, K., Nelson, K., Bergeson, R., McKee, R., et al. (2018) · Virology · doi:10.1016/j.virol.2018.02.010 · Cited by 20

Mkrn2 deficiency induces teratozoospermia and male infertility through p53/PERP-mediated apoptosis in testis

Jiang, B.-H., Qian, Y.-C., Xie, Y.-X., Wang, C.-S., Shi, Z., Jiang, C., Tang, Y., Qian, X., & Wang, L. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_76_19 · Cited by 20

Stress-Induced Cell-Cycle Activation in Tip60 Haploinsufficient Adult Cardiomyocytes

Fisher, J. B., Kim, M. S., Blinka, S. M., Ge, Z., Wan, T. C., Duris, C. B., Christian, D., Twaroski, K., North, P. E., Auchampach, J. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031569 · Cited by 20

Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC

Zhang, X., Pfeiffer, H. K., Mellert, H. S., Stanek, T. J., Sussman, R. T., Kumari, A., Yu, D., Rigoutsos, I., Thomas‐Tikhonenko, A., Seidel, H. E., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06297-11 · Cited by 20

Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60

Schirling, C., Heseding, C., Heise, F., Kesper, D. A., Klebes, A., Klein‐Hitpaß, L., Vortkamp, A., Hoffmann, D. E., Saumweber, H., & Ehrenhofer‐Murray, A. E. (2009) · Chromosoma · doi:10.1007/s00412-009-0247-z · Cited by 20

p73-Binding Partners and Their Functional Significance

Ozaki, T., Kubo, N., & Nakagawara, A. (2010) · International Journal of Proteomics · doi:10.1155/2010/283863 · Cited by 20

Integration of Apoptosis and MetabolismPreprint

Yi, C., Vakifahmetoglu-Norberg, H., & Yuan, J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010777 · Cited by 20

Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury

Wang, X., Wan, T. C., Harty, K. R., Lauth, A., Smith, B. C., Lough, J., & Auchampach, J. A. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049786 · Cited by 19

Unbiased interrogation of functional lysine residues in human proteome

Bao, Y., Pan, Q., Xu, P., Liu, Z., Zhang, Z., Liu, Y., Xu, Y., Yu, Y., Zhou, Z. L., & Wei, W. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.033 · Cited by 19

Reactive Oxygen Species-Mediated p53 Core-Domain Modifications Determine Apoptotic or Necrotic Death in Cancer Cells

Gogna, R., Madan, E., Kuppusamy, P., & Pati, U. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4103 · Cited by 20

The Histone Acetyltransferase hMOF is Overexpressed in Non-small Cell Lung Carcinoma

Song, J. S., Chun, S., Lee, J. Y., Kim, D. K., Kim, Y., & Jang, S. J. (2011) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2011.45.4.386 · Cited by 19

Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways

Su, W., Ho, Y.-C., Wu, C.-K., Hsu, S.-H., Shiu, J.-L., Huang, J.-C., Chang, S., Chiu, W., Hung, J., Liu, T.-L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04223-5 · Cited by 19

Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer

Fang, X., Lu, G., Ha, K., Lin, H., Ye, D., Zuo, Q., Fu, Y., Zou, C., & Zhang, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.11.028 · Cited by 19

The genetic landscape of 5T models for multiple myeloma

Maes, K., Boeckx, B., Vlummens, P., Veirman, K. D., Menu, E., Vanderkerken, K., Lambrechts, D., & Bruyne, E. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-33396-w · Cited by 20

TIP60 Represses Transcriptional Activity of p73β via an MDM2-bridged Ternary Complex

Kim, J.-W., Song, P. I., Jeong, M.-H., An, J., Lee, S., Jang, S., Song, K., Armstrong, C. A., & Choi, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800161200 · Cited by 19

Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2

Ozaki, T., Nakamura, M., & Shimozato, O. (2015) · Biomolecules · doi:10.3390/biom5042854 · Cited by 18

The new frontier in cancer research: Deciphering cancer epigenetics

Lohrum, M. A. E., Stunnenberg, H. G., & Logie, C. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.011 · Cited by 19

Functional investigations of p53 acetylation enabled by heterobifunctional molecules

Chen, L.-Y., Singha Roy, S. J., Jadhav, A. M., Wang, W. W., Chen, P.-H., Bishop, T., Erb, M. A., & Parker, C. G. (2024) · ACS Chemical Biology · doi:10.1021/acschembio.4c00438 · Cited by 18

MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

Chen, H., Sun, Y., Mittler, G., Rumpf, T., Shvedunova, M., Grosschedl, R., & Akhtar, A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114682 · Cited by 22

TIP60 up-regulates ΔNp63α to promote cellular proliferation

Stacy, A. J., Zhang, J., Craig, M. P., Hira, A., Dole, N., & Kadakia, M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010388 · Cited by 18

Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair

Zhang, J., Lu, X., MoghaddamKohi, S., Shi, L., Xu, X., & Zhu, W. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103206 · Cited by 18

VprBP/DCAF1 regulates p53 function and stability through site-specific phosphorylation

Ghate, N. B., Kim, S., Mehmood, R., Shin, Y., Kim, K., & An, W. (2023) · Oncogene · doi:10.1038/s41388-023-02685-8 · Cited by 20

Advances in the mechanism of small nucleolar RNA and its role in DNA damage response

Shen, L., Zhang, W., Deng, J.-R., Qi, Z., Lin, Z.-W., & Wang, Z. (2024) · Military Medical Research · doi:10.1186/s40779-024-00553-4 · Cited by 22

RNAi screening identifies KAT8 as a key molecule important for cancer cell survival.

Zhang, S., Liu, X., Zhang, Y., Cheng, Y., & Li, Y. (2013) · Europe PMC (PubMed Central) · Cited by 18

Lysine methylation and the regulation of p53

Carr, S. M., Munro, S., & Thangue, N. B. L. (2012) · Essays in Biochemistry · doi:10.1042/bse0520079 · Cited by 18

Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

Beckerman, R., Yoh, K. E., Mattia-Sansobrino, M., Zupnick, A., Laptenko, O., Karni-Schmidt, O., Ahn, J., Byeon, I. L., Keezer, S. M., & Prives, C. L. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1170270 · Cited by 19

Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction

Wang, X., Wan, T. C., Lauth, A., Purdy, A. L., Harty, K. R., Patterson, M., Lough, J., & Auchampach, J. A. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.09.012 · Cited by 17

hMOF induces cisplatin resistance of ovarian cancer by regulating the stability and expression of MDM2

Cai, M., Xu, S., Jin, Y., Yu, J., Dai, S., Shi, X., & Guo, R. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01478-y · Cited by 18

Aspirin‐Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis

Xie, L., Li, C., Wang, C., Wu, Z., Wang, C., Chen, C., Chen, X., Zhou, D., Zhou, Q., Lu, P., et al. (2024) · Advanced Science · doi:10.1002/advs.202306378 · Cited by 17

Activation of NFAT signal by p53‐K120R mutant

Shinmen, N., Koshida, T., Kumazawa, T., Sato, K., Shimada, H., Matsutani, T., Iwadate, Y., Takiguchi, M., & Hiwasa, T. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.04.041 · Cited by 17

An H4K16 histone acetyltransferase mediates decondensation of the X chromosome in C. elegans males

Lau, A. C., Zhu, K. P., Brouhard, E. A., Davis, M. B., & Csankovszki, G. (2016) · Epigenetics & Chromatin · doi:10.1186/s13072-016-0097-x · Cited by 17

Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1

Rivera-Colón, Y., Maguire, A., Liszczak, G., Olia, A. S., & Marmorstein, R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.752220 · Cited by 17

Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors

Harrod, R. (2019) · Retrovirology · doi:10.1186/s12977-019-0487-9 · Cited by 17

Effect of lysine side chain length on histone lysine acetyltransferase catalysis

Proietti, G., Wang, Y., Rainone, G., & Mecinović, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69510-0 · Cited by 19

Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity

Martin, S. D., Connor, T., Sanigorski, A., McEwen, K. A., Henstridge, D. C., Nijagal, B., De Souza, D., Tull, D. L., Meikle, P. J., Kowalski, G. M., et al. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-06319-5 · Cited by 16

p53 as the main traffic controller of the cell signaling network

Sebastian, S. (2010) · Frontiers in bioscience · doi:10.2741/3669 · Cited by 16

Grass Carp (Ctenopharyngodon idella) KAT8 Inhibits IFN 1 Response Through Acetylating IRF3/IRF7

Li, M., Hu, J., Mao, H., Li, D., Jiang, Z., Sun, Z., Yu, T., Hu, C., & Xu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.808159 · Cited by 16

New insights into the DNA repair pathway choice with NuA4/TIP60

Lashgari, A., Tchara, P.-E. K., Lambert, J., & Côté, J. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103315 · Cited by 17

Upregulation of SIRT1 Contributes to dmPGE2-dependent Radioprotection of Hematopoietic Stem Cells

Liu, L., Li, H., Patterson, A. M., Plett, P. A., Sampson, C. H., Mohammad, K. S., Capitano, M. L., Singh, P., Yao, C., Orschell, C. M., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10368-2 · Cited by 16

MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance

Wang, L., Yang, X., Zhao, K., Huang, S., Qin, Y., Chen, Z., Hu, X., Jin, G., & Zhou, Z. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113908 · Cited by 16

Lysine and arginine methylation of transcription factors

Giaimo, B. D., Ferrante, F., & Borggrefe, T. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05531-6 · Cited by 17

Orphan Nuclear Receptor PNR/NR2E3 Stimulates p53 Functions by Enhancing p53 Acetylation

Wen, Z. H., Pyeon, D., Wang, Y., Lambert, P. F., Xu, W., & Ahlquist, P. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05513-11 · Cited by 16

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence

Largeot, A., Pérez-Campo, F. M., Marinopoulou, E., Lie‐A‐Ling, M., Kouskoff, V., & Lacaud, G. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2015.12.006 · Cited by 16

Regulation of Cellular Processes by SUMO: Understudied Topics

Enserink, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50044-7_5 · Cited by 17

The “readers” of unacetylated p53 represent a new class of acidic domain proteins

Wang, D., Kon, N., Tavana, O., & Gu, W. (2017) · Nucleus · doi:10.1080/19491034.2017.1313939 · Cited by 16

Molecular mechanisms of cellular senescence and immortalization of human cells

Kiyono, T. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.12.1623 · Cited by 16

Shifting p53-induced senescence to cell death by TIS21 /BTG2/Pc3 gene through posttranslational modification of p53 protein

Choi, O. R., Ryu, M. S., & Lim, I. K. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.014 · Cited by 16

Therapeutic Role of Synthetic Lethality in ARID1A -Deficient Malignancies

Hein, K. Z., Stephen, B., & Fu, S. (2023) · Journal of Immunotherapy and Precision Oncology · doi:10.36401/jipo-22-37 · Cited by 17

The Janus Face of p53-Targeting Ubiquitin Ligases

Hao, Q., Chen, Y., & Zhou, X. Y. (2020) · Cells · doi:10.3390/cells9071656 · Cited by 16

The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice

Brénachot, X., Rigault, C., Nédélec, E., Laderrière, A., Khanam, T., Gouazé, A., Chaudy, S., Lemoine, A., Datiche, F., Gascuel, J., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.006 · Cited by 15

Gene and protein expression of progesterone receptor isoforms A and B, p53 and p21 in myometrium and uterine leiomyoma

Lora, V., Grings, A. O., Capp, E., Corleta, H. V. E., & Brum, I. S. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2245-2 · Cited by 15

Surgery-induced downregulation of hippocampal sirtuin-1 contributes to cognitive dysfunction by inhibiting autophagy and activating apoptosis in aged mice.

Fang, Q.-J., Chi, B., Lin, Q., Huang, C.-M., Jin, S.-W., Cai, J., Nan, K., Han, Y., Tao, Y., Cao, H., et al. (2020) · Europe PMC (PubMed Central) · Cited by 14

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements †

Millau, J., Bandele, O. J., Perron, J., Bastien, N., Bouchard, É. F., Gaudreau, L. R., Bell, D. A., & Drouin, R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1209 · Cited by 14

Regulation and function of histone acetyltransferase MOF

Yang, Y., Han, X., Guan, J., & Li, X. (2014) · Frontiers of Medicine · doi:10.1007/s11684-014-0314-6 · Cited by 14

Chemically-defined lactose-based autoinduction medium for site-specific incorporation of non-canonical amino acids into proteins

Muzika, M., Muskat, N. H., Sarid, S., Ben‐David, O., Mehl, R. A., & Arbely, E. (2018) · RSC Advances · doi:10.1039/c8ra04359k · Cited by 14

Identification of New p53 Acetylation Sites in COS-1 Cells

Joubel, A., Chalkley, R. J., Medzihradszky, K. F., Hondermarck, H., & Burlingame, A. L. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800487-mcp200 · Cited by 15

Histone acetyltransferase MOF is involved in suppression of endometrial cancer and maintenance of ERα stability

Wu, Y. M., Zeng, K., Wang, C., Wang, S., Sun, H., Liu, W., Wang, X., Niu, J., Cong, S., Zhou, X., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.090 · Cited by 13

Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes

Wang, X., Lupton, C., Lauth, A., Wan, T. C., Foster, P., Patterson, M., Auchampach, J. A., & Lough, J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.02.005 · Cited by 13

TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene

Liao, J., Cao, B., Deng, J., Zhou, X. Y., Strong, M. J., Zeng, S. X., Xiong, J., Flemington, E. K., & Lu, H. (2016) · Scientific Reports · doi:10.1038/srep23542 · Cited by 13

Mode of action of carboplatin via activating p53/miR‐145 axis in head and neck cancers

Kılıç, A., Barlak, N., Şanli, F., Aytatlı, A., Çapik, Ö., & Karataş, Ö. F. (2019) · The Laryngoscope · doi:10.1002/lary.28492 · Cited by 13

Cloning and characterization of two genes coding for the histone acetyltransferases, Elp3 and Mof, in brown planthopper (BPH), Nilaparvata lugens (Stål)

Zhu, Y., Xie, Z., Wang, J., Liu, Y., & Wang, J. (2012) · Gene · doi:10.1016/j.gene.2012.10.077 · Cited by 13

Crosstalk between site-specific modifications on p53 and histone H3

Warnock, L. J., Adamson, R., Lynch, C. J., & Milner, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210787 · Cited by 13

Activation of p53-regulated pro-survival signals and hypoxia-independent mitochondrial targeting of TIGAR by human papillomavirus E6 oncoproteins

Yapindi, L., Bowley, T. Y., Kurtaneck, N., Bergeson, R. L., James, K., Wilbourne, J., Harrod, C. K., Hernandez, B. Y., Emerling, B. E., Yates, C., et al. (2023) · Virology · doi:10.1016/j.virol.2023.05.004 · Cited by 15

A Novel Tumor suppressor network in squamous malignancies

Costa, C., Santos, M., Segrelles, C., Dueñas, M., Lara, M. F., Agirre, X., Prósper, F., García‐Escudero, R., & Paramio, J. M. (2012) · Scientific Reports · doi:10.1038/srep00828 · Cited by 12

Overexpression of SMAR1 Enhances Radiosensitivity in Human Breast Cancer Cell Line MCF7 via Activation of p53 Signaling Pathway

Liu, H.-C., Ma, F., Shen, Y., Hu, Y., & Pan, S. (2015) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504015x14424348426035 · Cited by 12

Retrotransposon‐derived p53 binding sites enhance telomere maintenance and genome protection

Lieberman, P. M. (2016) · BioEssays · doi:10.1002/bies.201600078 · Cited by 12

Treatment of Brain Edema by Wogonoside Is Associated with Inhibition of Neuronal Apoptosis and SIRT1 Activation in Rats

Cheng, Y., Li, S., Liu, Y., Li, J., Chen, Y., & Zhao, H. (2020) · Medical Science Monitor · doi:10.12659/msm.921250 · Cited by 12

The biology of papillomavirus PDZ associations: what do they offer papillomaviruses?

Thomas, M., & Banks, L. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.09.011 · Cited by 12

Curcumin Inhibits Histone Deacetylase Leading to Cell Cycle Arrest and Apoptosis via Upregulation of p21 in Breast Cancer Cell Lines

Mukherjee, S., Sarkar, R., Biswas, J., & Roy, M. (2012) · International Journal of Green Nanotechnology · doi:10.1080/19430892.2012.691799 · Cited by 12

Systematic Analysis of a Simple Adaptor Protein PDZK1: Ligand Identification, Interaction and Functional Prediction of Complex

Hu, S., Song, E., Tian, R., Ma, S., Yang, T., Mu, Y., Li, Y., Shao, C., Gao, S., & Gao, Y. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000233258 · Cited by 12

Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression

Kim, H., Zheng, X., & Lee, E. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311032 · Cited by 10

KAT8 is upregulated and recruited to the promoter of Atg8 by FOXO to induce H4 acetylation for autophagy under 20-hydroxyecdysone regulation

Liu, T., Zhao, Y.-M., Jin, K., Wang, J., & Zhao, X. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105704 · Cited by 11

Functional analysis of the acetylation of human p53 in DNA damage responses

Chung, S., Zhu, S., Xu, Y., & Fu, X. (2014) · Protein & Cell · doi:10.1007/s13238-014-0048-x · Cited by 11

Acetylation of the DNA Binding Domain Regulates Transcription-independent Apoptosis by p53

Sykes, S. M., Stanek, T. J., Frank, A. K., Murphy, M. E., & McMahon, S. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026096 · Cited by 88

Regulation of the tumor suppressor protein p53 by MYST family acetyltransferases

Sykes, S. M. (2007) · Scholarly Commons (University of Pennsylvania)

Regulating p53-mediated apoptosis by modulating DNA-binding domain acetylation

Mellert, H. S. (2011) · Scholarly Commons (University of Pennsylvania)

Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

Tang, Y., Luo, J., Zhang, W., & Gu, W. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.021 · Cited by 742

Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis

Mellert, H. S., Stanek, T. J., Sykes, S. M., Rauscher, F. J., Schultz, D., & McMahon, S. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.184663 · Cited by 37