The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β
Open accessAbstract
In many physiological and disease processes, TGF-β usurps branches of MAP kinase pathways in conjunction to Smads to induce apoptosis and epithelial to mesenchymal transition, but the detailed mechanism of how a MAP kinase cascade is activated by TGF-β receptors is not clear. We report here that TRAF6 is specifically required for the Smad-independent activation of JNK and p38 and its carboxyl TRAF homology domain physically interacts with TGF-β receptors. TGF-β induces K63-linked ubiquitination of TRAF6, and promotes association between TRAF6 and TAK1. Our results indicate that TGF-β activates JNK and p38 through a mechanism similar to that operating in the interleukin-1β/Toll-like receptor pathway.
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Cites
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Ubiquitin signalling in the NF-κB pathway
Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184
Cited by
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
Signaling mechanisms of the epithelial-mesenchymal transition
Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Metadata
- Authors
- Yamashita, M., Fatyol, K., Jin, C., Wang, X., Liu, Z., & Zhang, Y. E.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 31
- Issue
- 6
- Pages
- 918-924
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2148392040
- Cited by
- 559
- References
- 2
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yamashita, M., Fatyol, K., Jin, C., Wang, X., Liu, Z., & Zhang, Y. E. (2008). TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.09.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
