The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures
Open accessAbstract
SUMMARY MicroRNAs are emerging as important regulators of diverse biological processes and pathologies in animals and plants. While hundreds of human miRNAs are known, only a few have known functions. Here we predict human microRNA functions by using a new method that systematically assesses the statistical enrichment of several miRNA targeting signatures in annotated gene sets such as signaling networks and protein complexes. Some of our top predictions are supported by published experiments, yet many are entirely new or provide mechanistic insights to known phenotypes. Our results indicate that coordinate miRNA targeting of closely connected genes is prevalent across pathways. We use the same method to infer which microRNAs regulate similar targets and provide the first genome-wide evidence of pervasive co-targeting, where a handful of “hub” microRNAs are involved in a majority of co-targeting relationships. Our method and analyses pave the way to systematic discovery of microRNA functions.
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Statistical significance for genomewide studies
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Combinatorial microRNA target predictions
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Silencing of microRNAs in vivo with ‘antagomirs’
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The impact of microRNAs on protein output
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Widespread changes in protein synthesis induced by microRNAs
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A microRNA component of the p53 tumour suppressor network
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Cited by
Predicting effective microRNA target sites in mammalian mRNAs
Agarwal, V., Bell, G. W., Nam, J.-W., & Bartel, D. P. (2015) · eLife · doi:10.7554/elife.05005 · Cited by 7,318
Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert, M. S., & Sharp, P. A. (2012) · Cell · doi:10.1016/j.cell.2012.04.005 · Cited by 1,564
Self-citationMicroRNA functions in stress responses
Leung, A. K. L., & Sharp, P. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.027 · Cited by 865
MicroRNA sponges: Progress and possibilities
Ebert, M. S., & Sharp, P. A. (2010) · RNA · doi:10.1261/rna.2414110 · Cited by 762
Self-citationA network-biology perspective of microRNA function and dysfunction in cancer
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Metadata
- Authors
- Tsang, J. S., Ebert, M. S., & van Oudenaarden, A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 38
- Issue
- 1
- Pages
- 140-153
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1585067897
- Cited by
- 217
- References
- 18
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
