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Cited by 358

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

Open access
Durfee, Larissa A., Lyon, Nancy, Seo, Kyungwoon, Huibregtse, Jon M.·2010·Molecular Cell
DOI 10.1016/j.molcel.2010.05.002
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Abstract

Summary ISG15 is an interferon-induced and anti-viral ubiquitin-like protein (Ubl). Herc5, the major E3 enzyme for ISG15, mediates the ISGylation of over 300 proteins in interferon-stimulated cells. In addressing this broad substrate selectivity of Herc5, we found that: 1) the range of substrates extends even further and includes many exogenously expressed foreign proteins, 2) ISG15 conjugation is restricted to newly synthesized pools of proteins, and 3) Herc5 is physically associated with polyribosomes. These results lead to a model for ISGylation in which Herc5 broadly modifies newly synthesized proteins in a co-translational manner. This represents a novel mechanism for conjugation of a Ubl and further suggests that, in the context of an interferon-stimulated cell, newly translated viral proteins may be primary targets of ISG15. Consistent with this, we demonstrate that ISGylation of human papillomavirus (HPV) L1 capsid protein has a dominant-inhibitory effect on the infectivity of HPV16 pseudoviruses.

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Metadata

Authors
Durfee, L. A., Lyon, N., Seo, K., & Huibregtse, J. M.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2010-06
Volume
38
Issue
5
Pages
722-732
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2010.05.002
OpenAlex
W1975423316
Cited by
358
References
42
FWCI
6.67
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15. https://app.cochat.ai/papers/10.1016/j.molcel.2010.05.002
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Durfee, L. A., Lyon, N., Seo, K., & Huibregtse, J. M. (2010). The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.05.002

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.