The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Open accessAbstract
SUMMARY Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.
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Cites
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Self-citationHypoxia — a key regulatory factor in tumour growth
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
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Hypoxia signalling in cancer and approaches to enforce tumour regression
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Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Wang, T., Gilkes, D. M., Takano, N., Xiang, L., Luo, W., Bishop, C. J., Chaturvedi, P., Green, J. J., & Semenza, G. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410041111 · Cited by 493
Self-citationSET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314
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Self-citationChromatin and oxygen sensing in the context of JmjC histone demethylases
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Metadata
- Authors
- Lee, J. S., Kim, Y., Kim, I. S., Kim, B., Choi, H. J., Lee, J. M., Shin, H.-J. R., Kim, J. H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G. L., Kim, M., Kim, K. I., Hwang, D., & Baek, S. H.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 39
- Issue
- 1
- Pages
- 71-85
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2028074916
- Cited by
- 166
- References
- 11
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, J. S., Kim, Y., Kim, I. S., Kim, B., Choi, H. J., Lee, J. M., Shin, H.-J. R., Kim, J. H., Kim, J.-Y., Seo, S.-B., Lee, H., Binda, O., Gozani, O., Semenza, G. L., Kim, M., Kim, K. I., Hwang, D., & Baek, S. H. (2010). Negative Regulation of Hypoxic Responses via Induced Reptin Methylation. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.06.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
