Cited by 100Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer, Hypoxia, and Metabolism

Chromatin and oxygen sensing in the context of JmjC histone demethylases

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Shmakova, Alena, Batie, Michael, Druker, Jimena, Rocha, Sonia·2014·Biochemical Journal

Abstract

Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition. Although it is appreciated that gene expression is co-ordinated by changes in transcription and translation in hypoxia, much less is known about how chromatin changes allow for transcription to take place. The missing link between co-ordinating chromatin structure and the hypoxia-induced transcriptional programme could be in the form of a class of dioxygenases called JmjC (Jumonji C) enzymes, the majority of which are histone demethylases. In the present review, we will focus on the function of JmjC histone demethylases, and how these could act as oxygen sensors for chromatin in hypoxia. The current knowledge concerning the role of JmjC histone demethylases in the process of organism development and human disease will also be reviewed.

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  • Hypoxia can potentially impact DNA and histone methylation because the demethylase enzymes are dioxygenases and require oxygen and 2-oxoglutarate for their activity.

    “Hypoxia can potentially impact on DNA and histone methylation since the demethylase enzymes are dioxygenases, and so require oxygen and 2-oxoglutarate for their activity (501).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [501]

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Authors
Shmakova, A., Batie, M., Druker, J., & Rocha, S.
Affiliations
  • University of Dundee (GB)
  • Centre for Gene Regulation and Expression, MSI/WTB/JBC Complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, U.K.
Corresponding author
  • Shmakova, Alena
  • Batie, Michael
  • Druker, Jimena
Venue
Biochemical Journal
Published
2014-08-22
Volume
462
Issue
3
Pages
385-395
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W2167617091
Cited by
99
References
146
Citations by year
2026: 5 · 2025: 2 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 15 · 2020: 14 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 1
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (C99667/A12918, 097945, 097945/B/11/Z)
  • Cancer Research UK (C99667/A12918, 097945/B/11/Z, A12918, 12918)
  • Tenovus
  • Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords
oxygen sensing, hypoxia, chromatin structure, histone demethylation, dioxygenase, transcriptional regulation, gene expression, development (biology), human disease
MeSH terms
Chromatin, Histones, Humans, Oxygen, Transcription, Genetic, Cell Hypoxia, Jumonji Domain-Containing Histone Demethylases

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