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The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor
Open accessAbstract
Summary Chromatin remodelers are ATP-driven machines that assemble, slide, and remove nucleosomes from DNA, but how the ATPase motors of remodelers are regulated is poorly understood. Here we show that the double chromodomain unit of the Chd1 remodeler blocks DNA binding and activation of the ATPase motor in the absence of nucleosome substrates. The Chd1 crystal structure reveals that an acidic helix joining the chromodomains can pack against a DNA-binding surface of the ATPase motor. Disruption of the chromodomain-ATPase interface prevents discrimination between nucleosomes and naked DNA and reduces the reliance on the histone H4 tail for nucleosome sliding. We propose that the chromodomains allow Chd1 to distinguish between nucleosomes and naked DNA by physically gating access to the ATPase motor, and we hypothesize that related ATPase motors may employ a similar strategy to discriminate among DNA-containing substrates.
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PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
PHENIX : building new software for automated crystallographic structure determination
Adams, P. D., Grosse-Kunstleve, R. W., Hung, L.-W., Ioerger, T. R., McCoy, A. J., Moriarty, N. W., Read, R. J., Sacchettini, J. C., Sauter, N. K., & Terwilliger, T. C. (2002) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444902016657 · Cited by 4,361
Cited by
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Clapier, C. R., Iwasa, J., Cairns, B. R., & Peterson, C. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.26 · Cited by 1,305
Nucleosome Remodeling and Epigenetics
Becker, P. B., & Workman, J. L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a017905 · Cited by 355
Combinatorial complexity in chromatin structure and function: revisiting the histone code
Rando, O. J. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.02.013 · Cited by 269
Kloet, S. L., Baymaz, H. I., Makowski, M., Groenewold, V., Jansen, P. W. T. C., Berendsen, M., Niazi, H., Kops, G. J., & Vermeulen, M. (2015) · The FEBS Journal · doi:10.1111/febs.12972 · Cited by 107
SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules
Job, G., Brugger, C., Xu, T., Lowe, B. R., Pfister, Y., Qu, C., Shanker, S., Baños Sanz, J. I., Partridge, J. F., & Schalch, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.016 · Cited by 55
Metadata
- Authors
- Hauk, G., McKnight, J. N., Nodelman, I. M., & Bowman, G. D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 5
- Pages
- 711-723
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2029136195
- Cited by
- 215
- References
- 2
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hauk, G., McKnight, J. N., Nodelman, I. M., & Bowman, G. D. (2010). The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.08.012
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