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Elevated Histone Expression Promotes Life Span Extension
Open accessAbstract
Changes to the chromatin structure accompany aging, but the molecular mechanisms underlying aging and the accompanying changes to the chromatin are unclear. Here, we report a mechanism whereby altering chromatin structure regulates life span. We show that normal aging is accompanied by a profound loss of histone proteins from the genome. Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to their having decreased histone levels. Conversely, increasing the histone supply by inactivation of the histone information regulator (Hir) complex or overexpression of histones dramatically extends life span via a pathway that is distinct from previously known pathways of life span extension. This study indicates that maintenance of the fundamental chromatin structure is critical for slowing down the aging process and reveals that increasing the histone supply extends life span.
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“Overexpression of SIR2, histones, or deletion of the histone methyltransferase gene SET2, extends yeast lifespan, indicating that epigenetic changes are not merely a biomarker, but a cause of yeast aging (Dang et al., 2009; Feser et al., 2010; Hu et al., 2014; Kaeberlein et al., 1999; Ryu et al., 2014).”
From Loss of epigenetic information as a cause of mammalian aging (2023) · cites this paper as Feser et al., 2010
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“Nucleosome occupancy can decrease with age (Figure 2), and ameliorating this loss in yeast increases lifespan (Feser et al., 2010; Hu et al., 2014; Ivanov et al., 2013).”
From The Aging Epigenome (2016) · cites this paper as Feser et al., 2010
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Citations
Cites
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 9×
“Collectively, these data indicate that extra histone supply is unlikely to extend life span via the identical pathways by which ERC accumulation and Sir2 influence life span. ram (aged) from strain UCC5181 were subject to ChIP analysis for histone H3 pendent experiments, whose results are shown individually in Figures…”
BackgroundInfluentialHistone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,959
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293
Chromatin Challenges during DNA Replication and Repair
Groth, A., Rocha, W., Verreault, A., & Almouzni, G. (2007) · Cell · doi:10.1016/j.cell.2007.01.030 · Cited by 733
DNA methylation and histone modifications: teaming up to silence genes
Fuks, F. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.002 · Cited by 669
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667
The RCAF complex mediates chromatin assembly during DNA replication and repair
Tyler, J. K., Adams, C. R., Chen, S.-R., Kobayashi, R., Kamakaka, R. T., & Kadonaga, J. T. (1999) · Nature · doi:10.1038/990147 · Cited by 555
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Genetic analysis of spermatogenesis and aging in Drosophila
Bouska, M. J. (2021) · doi:10.31274/td-20240329-363
González-Meljem, J. M., Haston, S., Gallage, S., Innes, A. J., & Scheckhuber, C. Q. (2024) · Springer eBooks · doi:10.1007/978-3-031-76469-1_2
Aere perennius: how chromatin fidelity is maintained and lost in disease
Fetch, D. R., Jumamyradova, A., Chapa, C. M., Ge, Y., Mohamadzadeh, M., & Soshnev, A. A. (2025) · NAR Molecular Medicine · doi:10.1093/narmme/ugaf026
Exploring a crossroads in the aging process
Shabestary, K., & Gottschling, D. E. (2025) · eLife · doi:10.7554/elife.109320
SWR1C loss promotes longevity through tRNA-mediated proteostasisPreprint
Moreno‐Méndez, E., Meneses-Plascencia, J., Ulloa-Calzonzin, J., Salazar-Martinez, I., Balarezo-Cisneros, L. N., Sánchez‐Puig, N., Delneri, D., Oktaba, K., Funes, S., & DeLuna, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.05.692690
Additional file 13 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314321
Additional file 15 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314327
Additional file 3 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314345
Additional file 18 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314336
Additional file 8 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314360
Additional file 9 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314363
Additional file 10 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314303
Additional file 12 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314315
Additional file 4 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314348
Additional file 7 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314357
Additional file 14 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314324
Additional file 6 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314354
Additional file 17 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314333
Additional file 2 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314342
Additional file 16 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314330
Additional file 11 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314309
Additional file 1 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314339
Additional file 5 of H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner
Guillermo, A., Chocian, K., Gavriilidis, G., Vandamme, J., Salcini, A. E., Mellor, J., & Woollard, A. C. S. (2021) · Figshare · doi:10.6084/m9.figshare.14314351
Geisler, M. S., Kemp, J. P., Hill, C. A., Marzluff, W. F., & Duronio, R. J. (2026) · Genes & Development · doi:10.1101/gad.353837.126
Rôle et régulation de l'haptoglobine adipocytaire au cours du vieillissement
Astre, G. (2018) · theses.fr (ABES) · doi:10.70675/91523d31z8a53z44e6z8f1dzf0a02840a7e5
Johna, A., Sreya, S., Sengupta, T., Elumalai, P., Sengupta, A., Kumar, R., & Nishana, M. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.05.032
Krakowiak, M., Malinowska, A., Świderska, B., Patan, M., Kaczmarek, Ł., & Nawrot, R. (2026) · Zoological Journal of the Linnean Society · doi:10.1093/zoolinnean/zlag083
Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging
Zhu, Y., Wang, X., Li, Y., Jiang, W., Wu, Z., Xu, S., Tan, Z., Wu, A., Cai, Y., Yang, Y., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3287-6
Chromatin signaling in aging and cellular senescence
Gagné, L. M., Couteau, F., & Mallette, F. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-19001-8.00018-0
Kim, S., & Jazwinski, S. M. (2015) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6678-8_8
Metadata
- Authors
- Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K.
- Affiliations
- University of Colorado Anschutz (US)
- Howard Hughes Medical Institute (US)
- University of Saskatchewan (CA)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Tyler, Jessica K.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 5
- Pages
- 724-735
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3966075
- OpenAlex
- W1990955843
- Cited by
- 435
- References
- 62
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 21 · 2023: 29 · 2022: 19 · 2021: 48 · 2020: 33 · 2019: 27 · 2018: 36 · 2017: 23 · 2016: 28 · 2015: 32 · 2014: 25 · 2013: 30 · 2012: 25
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Cancer Center, University of Colorado
- National Cancer Institute (R01CA095641)
- National Institute of General Medical Sciences (GM64475, R01GM064475, T32-GM08370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- histone expression, lifespan extension, aging, chromatin structure, histone H3 lysine 56 acetylation, yeast
- MeSH terms
- Chromatin, Histones, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins
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