The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Elevated Histone Expression Promotes Life Span Extension
Open accessAbstract
Changes to the chromatin structure accompany aging, but the molecular mechanisms underlying aging and the accompanying changes to the chromatin are unclear. Here, we report a mechanism whereby altering chromatin structure regulates life span. We show that normal aging is accompanied by a profound loss of histone proteins from the genome. Indeed, yeast lacking the histone chaperone Asf1 or acetylation of histone H3 on lysine 56 are short lived, and this appears to be at least partly due to their having decreased histone levels. Conversely, increasing the histone supply by inactivation of the histone information regulator (Hir) complex or overexpression of histones dramatically extends life span via a pathway that is distinct from previously known pathways of life span extension. This study indicates that maintenance of the fundamental chromatin structure is critical for slowing down the aging process and reveals that increasing the histone supply extends life span.
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“Overexpression of SIR2, histones, or deletion of the histone methyltransferase gene SET2, extends yeast lifespan, indicating that epigenetic changes are not merely a biomarker, but a cause of yeast aging (Dang et al., 2009; Feser et al., 2010; Hu et al., 2014; Kaeberlein et al., 1999; Ryu et al., 2014).”
From Loss of epigenetic information as a cause of mammalian aging (2023) · cites this paper as Feser et al., 2010
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“Nucleosome occupancy can decrease with age (Figure 2), and ameliorating this loss in yeast increases lifespan (Feser et al., 2010; Hu et al., 2014; Ivanov et al., 2013).”
From The Aging Epigenome (2016) · cites this paper as Feser et al., 2010
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Citations
Cites
Crystal structure of the nucleosome core particle at 2.8 Å resolution
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 9×
“Collectively, these data indicate that extra histone supply is unlikely to extend life span via the identical pathways by which ERC accumulation and Sir2 influence life span. ram (aged) from strain UCC5181 were subject to ChIP analysis for histone H3 pendent experiments, whose results are shown individually in Figures…”
BackgroundInfluentialHistone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions
Shogren‐Knaak, M. A., Ishii, H., Sun, J.-M., Pazin, M. J., Davie, J., & Peterson, C. L. (2006) · Science · doi:10.1126/science.1124000 · Cited by 1,959
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293
Chromatin Challenges during DNA Replication and Repair
Groth, A., Rocha, W., Verreault, A., & Almouzni, G. (2007) · Cell · doi:10.1016/j.cell.2007.01.030 · Cited by 733
DNA methylation and histone modifications: teaming up to silence genes
Fuks, F. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.002 · Cited by 669
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667
The RCAF complex mediates chromatin assembly during DNA replication and repair
Tyler, J. K., Adams, C. R., Chen, S.-R., Kobayashi, R., Kamakaka, R. T., & Kadonaga, J. T. (1999) · Nature · doi:10.1038/990147 · Cited by 555
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Sorted by citations
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860
Self-citationEpigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 732
Loss of epigenetic information as a cause of mammalian aging
Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.027 · Cited by 643
Metadata
- Authors
- Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K.
- Affiliations
- University of Colorado Anschutz (US)
- Howard Hughes Medical Institute (US)
- University of Saskatchewan (CA)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Tyler, Jessica K.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 39
- Issue
- 5
- Pages
- 724-735
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3966075
- OpenAlex
- W1990955843
- Cited by
- 435
- References
- 62
- Citations by year
- 2026: 8 · 2025: 22 · 2024: 21 · 2023: 29 · 2022: 19 · 2021: 48 · 2020: 33 · 2019: 27 · 2018: 36 · 2017: 23 · 2016: 28 · 2015: 32 · 2014: 25 · 2013: 30 · 2012: 25
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Cancer Center, University of Colorado
- National Cancer Institute (R01CA095641)
- National Institute of General Medical Sciences (GM64475, R01GM064475, T32-GM08370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- histone expression, lifespan extension, aging, chromatin structure, histone H3 lysine 56 acetylation, yeast
- MeSH terms
- Chromatin, Histones, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, Saccharomyces cerevisiae Proteins
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