Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, Matt; Powers, R. Wilson; Steffen, Kristan K.; Westman, Eric A.; Hu, Di; Dang, Nick; Kerr, Emily O.; Kirkland, Kathryn T.; Fields, Stanley; Kennedy, Brian K.

doi:10.1126/science.1115535

Cited by 1,293Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics researchSirtuins and Resveratrol in Medicine

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, Matt, Powers, R. Wilson, Steffen, Kristan K., Westman, Eric A., Hu, Di, Dang, Nick, Kerr, Emily O., Kirkland, Kathryn T. +2 more·2005·Science

DOI 10.1126/science.1115535

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Abstract

Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae . From a large-scale analysis of 564 single-gene–deletion strains of yeast, we identified 10 gene deletions that increase replicative life span. Six of these correspond to genes encoding components of the nutrient-responsive TOR and Sch9 pathways. Calorie restriction of tor1 D or sch9 D cells failed to further increase life span and, like calorie restriction, deletion of either SCH9 or TOR1 increased life span independent of the Sir2 histone deacetylase. We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast.

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In yeast, TOR signalling seems required for longevity benefits of caloric restriction under some conditions.
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From The common biology of cancer and ageing (2007) · cites this paper as [89]

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Authors: Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Kaeberlein, Matt
Kennedy, Brian K.
ORCID: Kaeberlein, Matt
Fields, Stanley
Kennedy, Brian K.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2005-11-18
Volume: 310
Issue: 5751
Pages: 1193-1196
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1115535
OpenAlex: W2077612844
Cited by: 1,293
References: 24
Citations by year: 2026: 21 · 2025: 30 · 2024: 33 · 2023: 47 · 2022: 46 · 2021: 53 · 2020: 57 · 2019: 64 · 2018: 58 · 2017: 53 · 2016: 76 · 2015: 81 · 2014: 91 · 2013: 75 · 2012: 88
FWCI: 16.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P30AG013280)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: replicative lifespan, TOR signaling, caloric restriction, nutrient signaling, longevity, Saccharomyces cerevisiae, TOR1, Sch9
MeSH terms: Cell Division, Protein Kinases, Saccharomyces cerevisiae, Protein Serine-Threonine Kinases, Gene Deletion, Saccharomyces cerevisiae Proteins

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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