A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,954

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

Poly(ADP-ribose): novel functions for an old molecule

Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,975

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705

Doxorubicin‐induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2

Hou, J., Yun, Y. J., Xue, J., Jeon, B.-M., & Kim, S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6636 · Cited by 53

The Multifactorial Role of PARP-1 in Tumor Microenvironment

Martí, J. M., Fernández‐Cortés, M., Serrano-Sáenz, S., Zamudio-Martínez, E., Delgado‐Bellido, D., García-Díaz, Á., & Oliver, F. J. (2020) · Cancers · doi:10.3390/cancers12030739 · Cited by 55

Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

Liu, R. R., Li, J., Shao, J., Lee, J.-H., Qiu, X., Xiao, Y., Zhang, B., Hao, Y., Li, M., & Chen, Q. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.009 · Cited by 49

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy

Fan, Y., Cheng, J., Vasudevan, S. A., Patel, R. H., Li, L., Xu, X. Y., Zhao, Y., Jia, W., Lu, F., Zhang, H., et al. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0864-0 · Cited by 49

Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs

Hinojosa, C. A., Babu, R. A. S., Rahman, M. M., Fernandes, G., Boyd, A. R., & Orihuela, C. J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.007 · Cited by 49

Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation

Wang, W., Zhang, B., Mani, A. M., Wu, Z., Yu, F., Li, W., & Wu, Z. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.249151 · Cited by 49

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells

Cho, E.-A., Kim, E., Kwak, S.-J., & Juhnn, Y. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-36 · Cited by 47

Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-κB signaling pathway

Cheng, X. F., Yao, X., Xu, S., Pan, J., Yu, H., Bao, J., Guan, H., Lu, R., & Zhang, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.074 · Cited by 47

Monitoring the Levels of Cellular NF-κB Activation States

Meier‐Soelch, J., Mayr‐Buro, C., Juli, J. U., Leib, L., Linne, U., Dreute, J., Papantonis, A., Schmitz, M. L., & Kracht, M. (2021) · Cancers · doi:10.3390/cancers13215351 · Cited by 53

The Ubiquitin E3 Ligase LOSS OF GDU2 Is Required for GLUTAMINE DUMPER1-Induced Amino Acid Secretion in Arabidopsis

Pratelli, R., Guerra, D. D., Shi, Y., Wogulis, M. D., Kraft, E., Frommer, W. B., Callis, J., & Pilot, G. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.191965 · Cited by 45

IκBζ is a regulator for the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence

Alexander, E., Hildebrand, D. G., Kriebs, A., Obermayer, K., Manz, M., Rothfuss, O. C., Eßmann, F., & Schulze‐Osthoff, K. (2013) · Journal of Cell Science · doi:10.1242/jcs.128835 · Cited by 47

TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation

Liang, L., Fan, Y., Cheng, J., Cheng, D., Zhao, Y., Cao, B., Ma, L., An, L., Jia, W., Xu, S., et al. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.003 · Cited by 44

Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation

Wu, Y.-H., Wu, W.-S., Lin, L.-C., Liu, C.-S., Ho, S., Wang, B.-J., Huang, B., Yeh, Y.-L., Chiu, H., Yang, W.-L., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0760-0 · Cited by 42

Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells

Zheng, L., Su, J., Zhang, Z., Jiang, L., Wei, J., Xu, X., & Lv, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-77448-6 · Cited by 42

Phosphorylation of p65(RelA) on Ser547 by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress

Sabatel, H., Valentin, E. D., Gloire, G., Dequiedt, F., Piette, J. G., & Habraken, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038246 · Cited by 40

The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress

Marivin, A., Berthelet, J., Plenchette, S., & Dubrez, L. (2012) · Cells · doi:10.3390/cells1040711 · Cited by 42

Proteomic techniques to probe the ubiquitin landscape

Beaudette, P., Popp, O., & Dittmar, G. (2015) · PROTEOMICS · doi:10.1002/pmic.201500290 · Cited by 43

TSG101 associates with PARP1 and is essential for PARylation and DNA damage‐induced NF‐κB activation

Tufan, A. B., Lazarow, K., Kolesnichenko, M., Sporbert, A., von Kries, J. P., & Scheidereit, C. (2022) · The EMBO Journal · doi:10.15252/embj.2021110372 · Cited by 40

Importance of PIKKs in NF-κB activation by genotoxic stress

Sabatel, H., Pirlot, C., Piette, J. G., & Habraken, Y. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.105 · Cited by 39

Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity

Choudhary, S., Boldogh, I. R., & Brasier, A. R. (2016) · Journal of Innate Immunity · doi:10.1159/000442254 · Cited by 39

Inhibitor of Apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancers

Fulda, S. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.01.005 · Cited by 40

The crosstalk between DNA-damage responses and innate immunity

He, M., Jiang, H., Li, S., Xue, M., Wang, H., Zheng, C., & Tong, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112768 · Cited by 41

Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Chen, Y., Tang, C. S., Zhang, M., Huang, W., Xu, Y. K., Sun, H.-Y., Yang, F., Song, L., Wang, H., Mu, L., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0458-0 · Cited by 37

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Lala-Tabbert, N., Mrad, R. L., Timusk, K., Fukano, M., Holbrook, J., St-Jean, M., LaCasse, E. C., & Korneluk, R. G. (2019) · Skeletal Muscle · doi:10.1186/s13395-019-0201-6 · Cited by 37

RNAi Screening Identifies TAK1 as a Potential Target for the Enhanced Efficacy of Topoisomerase Inhibitors

Martin, S. E., Wu, Z., Gehlhaus, K., Jones, T. L., Zhang, Y., Guha, R., Miyamoto, S., Pommier, Y. G., & Caplen, N. J. (2011) · Current Cancer Drug Targets · doi:10.2174/156800911797264734 · Cited by 36

Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic‐Like Behaviors

Zhang, D., Liu, C., Li, H., & Jiao, J. (2020) · Advanced Science · doi:10.1002/advs.202002117 · Cited by 35

PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage

González, J. B., Auclair, S., Luan, S., Thomas, L., Atkins, K. M., Aslan, J. E., Thomas, L., Zhao, J., Zhao, Y., & Thomas, G. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.23 · Cited by 34

A serum protein signature of APOE genotypes in centenarians

Sebastiani, P., Monti, S., Morris, M. K., Gurinovich, A., Tanaka, T., Andersen, S. L., Sweigart, B., Ferrucci, L., Jennings, L. L., Glass, D. J., et al. (2019) · Aging Cell · doi:10.1111/acel.13023 · Cited by 30

ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I

Li, C., Wang, B., Tu, J., Liu, C., Wang, Y., Chen, J., Huang, Y., Liu, B., & Yuan, X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06911-3 · Cited by 35

DNA Damage-Induced NF-κB Activation in Human Glioblastoma Cells Promotes miR-181b Expression and Cell Proliferation

Xu, R., Liu, R.-Y., Wu, C., Zhao, Y., Yang, L., Yao, Y., & Xu, Y. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369748 · Cited by 34

LRRK2 interacts with ATM and regulates Mdm2–p53 cell proliferation axis in response to genotoxic stress

Chen, Z., Cao, Z., Zhang, W., Gu, M., Zhou, Z., Li, B., Li, J., Tan, E., & Zeng, L. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx337 · Cited by 34

The IκB kinase complex is a regulator of mRNA stability

Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., Tufan, A. B., Perder, B., Akalin, A., Chen, W., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798658 · Cited by 35

Some mutations in the xeroderma pigmentosum D gene may lead to moderate but significant radiosensitivity associated with a delayed radiation-induced ATM nuclear localization

Ferlazzo, M. L., Berthel, É., Granzotto, A., Devic, C., Sonzogni, L., Bachelet, J.-T., Pereira, S., Bourguignon, M., Sarasin, A. R., Mezzina, M., et al. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1694189 · Cited by 33

Function of microRNA‑124 in the pathogenesis of cancer (Review)

Liu, Y., Yang, Y., Wang, X., Yin, S., Liang, B., Zhang, Y., Fan, M., Fu, Z., Shen, C., Han, Y., et al. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5594 · Cited by 34

Effect of longevity genetic variants on the molecular aging rate

Gurinovich, A., Song, Z., Zhang, W., Federico, A. N., Monti, S., Andersen, S. L., Jennings, L. L., Glass, D. J., Barzilai, N., Milman, S., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00376-4 · Cited by 28

Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination

Yao, D., Arguez, M. A., He, P., Bent, A. F., & Song, J. (2021) · Molecular Plant · doi:10.1016/j.molp.2021.08.013 · Cited by 30

ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels

Shah, P., McGuigan, C. W., Cheng, S., Vanpouille‐Box, C., Demaria, S., Weiss, R. S., & Lammerding, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.875132 · Cited by 33

Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes

Janus, P., Szołtysek, K., Zając, G., Stokowy, T., Walaszczyk, A., Widłak, W., Wojtaś, B., Gielniewski, B., Iwanaszko, M., Braun, R., et al. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.02.011 · Cited by 31

POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway

Weng, T., & Koh, C.-G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.443 · Cited by 29

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity

Meng, Y., Liu, C., Shen, L., Zhou, M., Liu, W., Kowolik, C. M., Campbell, J. L., Zheng, L., & Shen, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz537 · Cited by 29

Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

Lodewick, J., Lamsoul, I., & Bex, F. (2011) · Viruses · doi:10.3390/v3060829 · Cited by 29

A quinazoline-derivative compound with PARP inhibitory effect suppresses hypertension-induced vascular alterations in spontaneously hypertensive rats

Magyar, K., Deres, L., Erős, K., Bruszt, K., Seress, L., Hamar, J., Hideg, K., Balogh, A., Gallyas, F., Sümegi, B., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.03.008 · Cited by 28

P53-induced protein with a death domain (PIDD): master of puppets?

Bock, F. J., Peintner, L., Tanzer, M. C., Manzl, C., & Villunger, A. (2012) · Oncogene · doi:10.1038/onc.2011.639 · Cited by 29

Viral Modulation of the DNA Damage Response and Innate Immunity: Two Sides of the Same Coin

Lopez, A., Doyle, R. N., Sandoval, C., Nisson, K., Yang, V. B., & Fregoso, O. I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167327 · Cited by 31

Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence

Jat, P., Perkins, N. D., & Mowla, S. N. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s36160 · Cited by 33

DNA-PK: gatekeeper for IKKγ/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation

Medunjanin, S., Putzier, M., Nöthen, T., Weinert, S., Kähne, T., Luani, B., Zuschratter, W., & Braun-Dullaeus, R. C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03411-y · Cited by 28

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation

Yao, K., Lee, S., Peng, C., Lim, D. Y., Yamamoto, H., Ryu, J., Lim, T., Chen, H., Jin, G., Zhao, Z., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0167-6 · Cited by 27

Deciphering the Role of Innate Immune NF-ĸB Pathway in Pancreatic Cancer

Khurana, N., Dodhiawala, P. B., Bulle, A. S., & Lim, K. (2020) · Cancers · doi:10.3390/cancers12092675 · Cited by 27

Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

Lu, Q., Chen, Y., Li, J., Zhu, F., & Zheng, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1139595 · Cited by 28

ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-αvβ3–Dependent Mechanisms

Jinushi, M., Chiba, S., Baghdadi, M., Kinoshita, I., Dosaka‐Akita, H., Ito, K., Yoshiyama, H., Yagita∥, H., Uede, T., & Takaoka, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2028 · Cited by 27

Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin

Tsuchida, M., Yokosawa, T., Noguchi, T., Shimada, T., Yamada, M., Sekiguchi, Y., Hirata, Y., & Matsuzawa, A. (2020) · The Journal of Toxicological Sciences · doi:10.2131/jts.45.219 · Cited by 27

Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage

Bock, F. J., Krumschnabel, G., Manzl, C., Peintner, L., Tanzer, M. C., Hermann‐Kleiter, N., Baier, G., Llacuna, L., Yélamos, J., & Villunger, A. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.152 · Cited by 27

PARP inhibition and postinfarction myocardial remodeling

Halmosi, R., Deres, L., Gál, R., Erős, K., Sümegi, B., & Tóth, K. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.223 · Cited by 28

HOXC10 promotes gastric cancer cell invasion and migration via regulation of the NF-κB pathway

Yao, S., He, L., Zhang, Y., Ye, L., Lai, Y., Huang, L., Wu, L., Wu, G., & Zhu, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.019 · Cited by 26

PARP inhibition attenuates early brain injury through NF-κB/MMP-9 pathway in a rat model of subarachnoid hemorrhage

Chen, T., Wang, W., Li, J., Xu, H., Peng, Y., Fan, L., Yan, F., Gu, C., Wang, L., & Chen, G. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.005 · Cited by 25

Sub-cellular localization specific SUMOylation in the heart

Le, N., Martin, J. F., Fujiwara, K., & Abe, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.018 · Cited by 25

Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system

Bound, N. T., Vandenberg, C. J., Kartikasari, A. E. R., Plebanski, M., & Scott, C. L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.886170 · Cited by 30

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis

Guan, S., Lu, J., Zhao, Y., Woodfield, S. E., Zhang, H., Xu, X. Y., Yu, Y., Zhao, J., Bieerkehazhi, S., Liang, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16895 · Cited by 25

Non‐canonical ATM/MRN activities temporally define the senescence secretory program

Malaquin, N., Carrier-Leclerc, A., Martinez, A., Dessureault, M., Ghadaouia, S., Coppé, J., Nadeau, S., Cardin, G., Campisi, J., & Rodier, F. (2020) · EMBO Reports · doi:10.15252/embr.202050718 · Cited by 25

ADP‐ribosylation in evasion, promotion and exacerbation of immune responses

Rosado, M. M., & Pioli, C. (2021) · Immunology · doi:10.1111/imm.13332 · Cited by 24

Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli

Sakamoto, K., Hikiba, Y., Nakagawa, H., Hirata, Y., Hayakawa, Y., Kinoshita, H., Nakata, W., Sakitani, K., Takahashi, R., Akanuma, M., et al. (2012) · Oncogene · doi:10.1038/onc.2012.192 · Cited by 24

SILAC for biomarker discovery

Dittmar, G., & Selbach, M. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400112 · Cited by 27

TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms

Suzuki, M., Asai, Y., Kagi, T., Noguchi, T., Yamada, M., Hirata, Y., & Matsuzawa, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249497 · Cited by 23

Poly (ADP-ribose) polymerase-1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension

Kaur, G., Singh, N., Lingeshwar, P., Siddiqui, H. H., & Hanif, K. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.11.004 · Cited by 23

Aspects of innate immunity and Parkinson's disease

Huang, Y., & Halliday, G. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00033 · Cited by 22

In silico and gene expression analysis of the acute inflammatory response of gilthead seabream (Sparus aurata) after subcutaneous administration of carrageenin

Campos‐Sánchez, J. C., Mayor-Lafuente, J., Guardiola, F. A., & Esteban, M. Á. (2021) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-00999-6 · Cited by 22

Radiation-induced neuroinflammation: a potential protective role for poly(ADP-ribose) polymerase inhibitors?

Gutierrez‐Quintana, R., Walker, D. J., Williams, K. J., Forster, D. M., & Chalmers, A. J. (2022) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab190 · Cited by 22

The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer

Mecca, M., Picerno, S., & Cortellino, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052750 · Cited by 24

Alternative nuclear functions for NF-κB family members.

Espinosa, L., Bigas, A., & Mulero, M. C. (2011) · Europe PMC (PubMed Central) · Cited by 22

NAD+ Degrading Enzymes, Evidence for Roles During Infection

Tan, A., & Doig, C. L. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.697359 · Cited by 23

Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells

Li, S., Wang, J., Lu, Y., Zhao, Y., Prinz, R. A., & Xu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03744-2 · Cited by 21

ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method

Daniels, C. M., Ong, S., & Leung, A. K. L. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6993-7_7 · Cited by 21

Oxygen sensing is impaired in ATM-defective cells

Mongiardi, M. P., Stagni, V., Natoli, M., Giaccari, D., D’Agnano, I., Falchetti, M. L., Barilà, D., & Levi, A. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18663 · Cited by 20

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

Konrath, F., Mittermeier, A., Cristiano, E., Wolf, J., & Loewer, A. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007901 · Cited by 20

Design and Synthesis of New Thiophene/Thieno[2,3-d]pyrimidines along with Their Cytotoxic Biological Evaluation as Tyrosine Kinase Inhibitors in Addition to Their Apoptotic and Autophagic Induction

Elmongy, E. I., Attallah, N. G. M., Altwaijry, N., AlKahtani, M. M., & Henidi, H. A. (2021) · Molecules · doi:10.3390/molecules27010123 · Cited by 20

An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks

Wu, Z., Wang, C., Bai, M., Li, X., Mei, Q., Li, X., Wang, Y., Fu, X., Luo, G., & Han, W. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv161 · Cited by 21

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

Zhang, S., Pan, D., Jia, X.-M., Lin, X., & Zhao, X. (2017) · Protein & Cell · doi:10.1007/s13238-017-0441-3 · Cited by 19

IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation

Hwang, B., McCool, K. W., Wan, J., Wuerzberger‐Davis, S. M., Young, E. W. K., Choi, E. Y., Cingolani, G., Weaver, B. A. A., & Miyamoto, S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645960 · Cited by 20

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

Nagane, M., Yasui, H., Sakai, Y., Yamamori, T., Niwa, K., Hattori, Y., Kondo, T., & Inanami, O. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.002 · Cited by 19

c IAP 1/2 negatively regulate RANKL ‐induced osteoclastogenesis through the inhibition of NFAT c1 expression

Yamaguchi, N., Yokota, M., Taguchi, Y., Gohda, J., & Inoue, J. (2012) · Genes to Cells · doi:10.1111/gtc.12012 · Cited by 18

Modulation of inflammation and disease tolerance by DNA damage response pathways

Neves‐Costa, A., & Moita, L. F. (2016) · FEBS Journal · doi:10.1111/febs.13910 · Cited by 20

Tumor Necrosis Factor Receptor-associated Factor Family Protein 2 Is a Key Mediator of the Epidermal Growth Factor-induced Ribosomal S6 Kinase 2/cAMP-responsive Element-binding Protein/Fos Protein Signaling Pathway

Peng, C., Zhu, F., Wen, W., Yao, K., Li, S., Zykova, T. A., Liu, K., Li, X., Ma, W., Bode, A. M., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359521 · Cited by 18

Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1

Wang, J., Liu, K., Xiao, T.-X., Liu, P.-G., Prinz, R., & Xu, X. (2022) · Oncoimmunology · doi:10.1080/2162402x.2021.2016159 · Cited by 16

Post-Transcriptional Control of mRNA Metabolism and Protein Secretion: The Third Level of Regulation within the NF-κB System

Priester, J., Dreute, J., Kracht, M., & Schmitz, M. L. (2022) · Biomedicines · doi:10.3390/biomedicines10092108 · Cited by 19

Inflammation and Late-Life Depression: Unraveling the Complex Relationship and Potential Therapeutic Strategies

Xia, J., Chen, M., Shao, H., Chen, H., Zhu, S., Zhao, M., Luo, W., Yang, J., & Wu, S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2812356 · Cited by 17

Irradiated tumour cell-derived microparticles upregulate MHC-I expression in cancer cells via DNA double-strand break repair pathway

Deng, S., Wang, J., Hu, Y., Sun, Y., Yang, X., Zhang, B., Deng, Y., Wei, W., Zhang, Z., Wen, L., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216898 · Cited by 20

Cytosolic DNA Triggers Mitochondrial Apoptosis via DNA Damage Signaling Proteins Independently of AIM2 and RNA Polymerase III

Wenzel, M., Wunderlich, M. T., Besch, R., Poeck, H., Willms, S., Schwantes, A., Kremer, M., Sutter, G., Endres, S., Schmidt, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100523 · Cited by 17

The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice

Riedlinger, T., Haas, J., Busch, J., van de Sluis, B., Kracht, M., & Schmitz, M. L. (2018) · Biomedicines · doi:10.3390/biomedicines6010036 · Cited by 18

ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage

Bournique, E., Sanchez, A., Oh, S., Ghazarian, D., Mahieu, A. L., Manjunath, L., Ednacot, E. M. Q., Ortega, P., Masri, S., Marazzi, I., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01417-0 · Cited by 20

Reciprocal interplay between OTULIN–LUBAC determines genotoxic and inflammatory NF-κB signal responses

Li, M., Li, L., Asemota, S., Kakhniashvili, D. G., Narayanan, R., Wang, X., & Liao, F. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2123097119 · Cited by 16

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase.

Shao, L., Wu, L., & Zhou, D. (2012) · PubMed · doi:10.3978/j.issn.2218-676x.2012.05.04 · Cited by 16

SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells

Huang, W. G., Liang, Y., Dong, J., Zhou, L., Gao, C., Jiang, C., Chen, M., Long, Y., & Xu, Y. (2017) · Mediators of Inflammation · doi:10.1155/2017/1685194 · Cited by 16

Fibroblasts from Retinoblastoma Patients Show Radiosensitivity Linked to Abnormal Localization of the ATM Protein

Lakhdar, I. M., Ferlazzo, M. L., Al-Choboq, J., Berthel, É., Sonzogni, L., Devic, C., Granzotto, A., Thariat, J., & Foray, N. (2020) · Current Eye Research · doi:10.1080/02713683.2020.1808998 · Cited by 15

Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S. B., Nist, A., Stiewe, T., Kracht, M., & Schmitz, M. L. (2019) · Cancers · doi:10.3390/cancers11060883 · Cited by 14

Innate Immune-Directed NF-κB Signaling Requires Site-Specific NEMO Ubiquitination

Jun, J., Kertesy, S. B., Jones, M. B., Marinis, J. M., Cobb, B. A., Tigno-Aranjuez, J. T., & Abbott, D. W. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.036 · Cited by 15

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma

Campolo, M., Lanza, M., Casili, G., Paterniti, I., Filippone, A., Caffo, M., Cardali, S. M., Puliafito, I., Colarossi, C., Raciti, G., et al. (2020) · Cancers · doi:10.3390/cancers13010041 · Cited by 14

Cezanne Paints Inflammation by Regulating Ubiquitination

Abe, J., & Berk, B. C. (2013) · Circulation Research · doi:10.1161/circresaha.113.301518 · Cited by 14

Regulation of cellular senescence by innate immunity

Hou, J., Zheng, Y., & Gao, C. (2023) · Biophysics Reports · doi:10.52601/bpr.2023.230032 · Cited by 17

The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection.

Marinoglou, K. (2012) · Europe PMC (PubMed Central) · Cited by 13

CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors

Mucka, P., Lindemann, P., Bosco, B., Willenbrock, M., Radetzki, S., Neuenschwander, M., Brischetto, C., von Kries, J. P., Nazaré, M., & Scheidereit, C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.06.027 · Cited by 13

Signals from the Nucleus: Activation of NF-κB by Cytosolic ATM in the DNA Damage Response

Hadian, K., & Krappmann, D. (2011) · Science Signaling · doi:10.1126/scisignal.2001712 · Cited by 57

A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.

Stilmann, M., Hinz, M., Arslan, S. Ç., Zimmer, A., Schreiber, V., & Scheidereit, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.032 · Cited by 232

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

Wu, Z.-H., Wong, E. T., Shi, Y., Niu, J., Chen, Z. J., Miyamoto, S., & Tergaonkar, V. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.010 · Cited by 209

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515

Sumoylating NEMO

(2003) · Science s STKE · doi:10.1126/stke.2112003tw464