The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
Open accessAbstract
We present a molecular dissection of pause site-dependent transcriptional termination for mammalian RNA polymerase II (Pol II)-transcribed genes. We show that nascent transcripts form RNA/DNA hybrid structures (R-loops) behind elongating Pol II and are especially prevalent over G-rich pause sites positioned downstream of gene poly(A) signals. Senataxin, a helicase protein associated with AOA2/ALS4 neurodegenerative disorders, acts to resolve these R-loop structures and by so doing allows access of the 5'-3' exonuclease Xrn2 at 3' cleavage poly(A) sites. This affords 3' transcript degradation and consequent Pol II termination. In effect, R-loops formed over G-rich pause sites, followed by their resolution by senataxin, are key steps in the termination process.
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Nechaev, S., Fargo, D. C., dos Santos, G., Liu, L., Gao, Y., & Adelman, K. (2010) · Science · doi:10.1126/science.1181421 · Cited by 424
Ashe, M. P., Griffin, P., James, W., & Proudfoot, N. J. (1995) · Genes & Development · doi:10.1101/gad.9.23.3008 · Cited by 125
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Metadata
- Authors
- Skourti-Stathaki, K., Proudfoot, N. J., & Gromak, N.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 42
- Issue
- 6
- Pages
- 794-805
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2161887614
- Cited by
- 819
- References
- 2
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Skourti-Stathaki, K., Proudfoot, N. J., & Gromak, N. (2011). Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.04.026
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