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Cited by 244

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

Open access
Kim, Hyungsoo, Scimia, Maria C., Wilkinson, Deepti, Trelles, Ramon D., Wood, Malcolm R., Bowtell, David, Dillin, Andrew, Mercola, Mark, Ronai, Ze'ev A.·2011·Molecular Cell
DOI 10.1016/j.molcel.2011.08.045
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Abstract

SUMMARY Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological conditions. Here we demonstrate that hypoxia induces fission of mitochondrial membranes, dependent on availability of the mitochondrial scaffolding protein AKAP121. AKAP121 controls mitochondria dynamics through PKA-dependent inhibitory phosphorylation of Drp1 and PKA-independent inhibition of Drp1-Fis1 interaction. Reduced availability of AKAP121 by the ubiquitin ligase Siah2 relieves Drp1 inhibition by PKA and increases its interaction with Fis1, resulting in mitochondrial fission. High AKAP121 levels, seen in cells lacking Siah2, attenuate fission and reduce apoptosis of cardiomyocytes under simulated ischemia. Infarct size and degree of cell death were reduced in Siah2−/− mice subjected to myocardial infarction. Inhibition of Siah2 or Drp1 in hatching C. elegans reduces their life span. Through modulating Fis1/Drp1 complex availability, our studies identify Siah2 as a key regulator of hypoxia-induced mitochondrial fission and its physiological significance in ischemic injury and nematode life span.

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Metadata

Authors
Kim, H., Scimia, M. C., Wilkinson, D., Trelles, R. D., Wood, M. R., Bowtell, D., Dillin, A., Mercola, M., & Ronai, Z. A.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2011-11
Volume
44
Issue
4
Pages
532-544
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2011.08.045
OpenAlex
W2009547397
Cited by
244
References
8
FWCI
5.76
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia. https://app.cochat.ai/papers/10.1016/j.molcel.2011.08.045
The paper
Kim, H., Scimia, M. C., Wilkinson, D., Trelles, R. D., Wood, M. R., Bowtell, D., Dillin, A., Mercola, M., & Ronai, Z. A. (2011). Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia. Molecular Cell. https://doi.org/10.1016/j.molcel.2011.08.045

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.