Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

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Development by Self-Digestion

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Hypoxia-inducible factors in physiology and medicine

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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The mechanism of eukaryotic translation initiation and principles of its regulation

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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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Autophagy in Human Health and Disease

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Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

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The Respiratory Chain and Oxidative Phosphorylation

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The machinery of macroautophagy

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Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

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Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

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Impact of epoetin alfa on clinical end points in patients with chronic renal failure: A meta-analysis

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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

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Hypoxia signalling in cancer and approaches to enforce tumour regression

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

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Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

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Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

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ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

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The GLUT4 Glucose Transporter

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Lactate Metabolism in Human Lung Tumors

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HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

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Hypoxia-Induced Angiogenesis: Good and Evil

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Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

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Translational control by 5′-untranslated regions of eukaryotic mRNAs

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Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responsePreprint

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Complex iii releases superoxide to both sides of the inner mitochondrial membrane

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Endoplasmic reticulum stress signalling-from basic mechanisms to clinical applications

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A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

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The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

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Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

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ROS-dependent signal transduction

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Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

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Autophagy and Tumor Metabolism

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

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Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

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Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

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Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

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Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants

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ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

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Hypoxia and Metabolic Adaptation of Cancer Cells

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Targeting renal cell carcinoma with a HIF-2 antagonist

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Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

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MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

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Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

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ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer

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Mitochondrial composition and function under the control of hypoxia

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Hypoxia-induced autophagy: cell death or cell survival?

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

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Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

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Taking a good look at free radicals in the aging process

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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

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