Bioenergetic role of mitochondrial fusion and fission
Open accessAbstract
Mitochondria are highly dynamic organelles. Frequent cycles of fusion and fission adapt the morphology of the mitochondrial compartment to the metabolic needs of the cell. Mitochondrial fusion is particularly important in respiratory active cells. It allows the spreading of metabolites, enzymes, and mitochondrial gene products throughout the entire mitochondrial compartment. This serves to optimize mitochondrial function and counteracts the accumulation of mitochondrial mutations during aging. Fragmented mitochondria are frequently found in resting cells, and mitochondrial fission plays an important role in the removal of damaged organelles by autophagy. Thus, mitochondrial fusion and fission both contribute to maintenance of mitochondrial function and optimize bioenergetic capacity. Multiple signalling pathways regulate the machinery of mitochondrial dynamics to adapt the shape of the mitochondrial compartment to the metabolic conditions of the cell. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012).
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During mitochondrial fission, cytosolic Drp1 is recruited to mitochondrial receptors (e.g., Fis1), allowing mitochondrial partitioning, turnover and reduction of network size under low energetic demand.
“During mitochondrial fission, cytosolic Drp1 is recruited to mitochondrial receptors (e.g., Fis1)3,4, allowing mitochondrial partitioning, turnover and reduction of network size under low energetic demand4,7.”
From Altered mitochondrial dynamics and function in APOE4-expressing astrocytes (2020) · cites this paper as [7]
The Introduction says Drp1 assembles on the mitochondrial surface to mediate fission, and section 4 describes partitioning during cell division and the removal of damaged mitochondria after fission. Sections 2 and 6 associate fragmented mitochondria with resting or respiratory-inactive cells. Our copy does not establish recruitment of cytosolic Drp1 by Fis1 or say that fission reduces network size specifically in response to low energetic demand. Page numbers are unavailable in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredMitochondrial fusion is particularly important in respiratory active cells, such as neurons.
“Mitochondrial fusion is particularly important in respiratory active cells, such as neurons [36].”
From APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons (2024) · cites this paper as [36]
Mitochondrial fusion is enhanced under stress and high energetic demands, allowing increased bioenergetic efficiency.
“Mitochondrial fusion is enhanced under stress and high energetic demands, allowing increased bioenergetic efficiency7.”
From Altered mitochondrial dynamics and function in APOE4-expressing astrocytes (2020) · cites this paper as [7]
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- Authors
- Westermann, B.
- Affiliations
- University of Bayreuth (DE)
- Corresponding author
- Westermann, Benedikt
- ORCID
- Westermann, Benedikt
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 1817
- Issue
- 10
- Pages
- 1833-1838
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2062407677
- Cited by
- 687
- References
- 12
- Citations by year
- 2026: 40 · 2025: 42 · 2024: 58 · 2023: 56 · 2022: 59 · 2021: 78 · 2020: 70 · 2019: 63 · 2018: 66 · 2017: 47 · 2016: 39 · 2015: 25 · 2014: 15 · 2013: 18 · 2012: 10
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- ERef Bayreuth (University of Bayreuth) (submittedVersion)
- Biochimica et Biophysica Acta
- Funders
- Deutsche Forschungsgemeinschaft (We 2174/4-2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial fusion, mitochondrial fission, mitochondrial dynamics, mitochondrial morphology, bioenergetics, mitochondrial metabolism, mitophagy, mitochondrial mutations, aging, mitochondrial fragmentation, signaling pathways
- MeSH terms
- Aging, Animals, Autophagy, Energy Metabolism, Humans, Mitochondria, Mutation, Signal Transduction, Mitochondrial Dynamics
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