Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

Pruneda, Jonathan N., Littlefield, Peter J., Soss, Sarah E., Nordquist, Kyle A., Chazin, Walter J., Brzovic, Peter S., Klevit, Rachel E.·2012·Molecular Cell
DOI 10.1016/j.molcel.2012.07.001

Cited by (347)

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  3. Molecular basis for specificity of the Met1-linked polyubiquitin signal
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  7. Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer
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  13. Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control
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  14. Functional conservation and divergence of the helix‐turn‐helix motif of E2 ubiquitin‐conjugating enzymes
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  16. Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets
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  17. Structural Biology: Parkin’s Serpentine Shape Revealed in the Year of the Snake
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  18. The Role of Conformational Dynamics in the Recognition and Regulation of Ubiquitination
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  19. Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination
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  20. Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K
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  22. Exploring the RING-Catalyzed Ubiquitin Transfer Mechanism by MD and QM/MM Calculations
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  49. A protein engagement RING
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  99. Faculty Opinions recommendation of Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.
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  100. Faculty Opinions recommendation of Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction.
    Vladimir Nikolaevich Uversky · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature