The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation
Open accessAbstract
The extracellular signal-regulated kinase (ERK) plays a central role in the signaling cascades of cell growth. Here, we show that stochastic ERK activity pulses regulate cell proliferation rates in a cell density-dependent manner. A fluorescence resonance energy transfer (FRET) biosensor revealed that stochastic ERK activity pulses fired spontaneously or propagated from adjacent cells. Frequency, but not amplitude, of ERK activity pulses exhibited a bell-shaped response to the cell density and correlated with cell proliferation rates. Consistently, synthetic ERK activity pulses generated by a light-switchable CRaf protein accelerated cell proliferation. A mathematical model clarified that 80% and 20% of ERK activity pulses are generated by the noise and cell-to-cell propagation, respectively. Finally, RNA sequencing analysis of cells subjected to the synthetic ERK activity pulses suggested the involvement of serum responsive factor (SRF) transcription factors in the gene expression driven by the ERK activity pulses.
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Cites
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Kholodenko, B. N. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01197.x · Cited by 643
Ets ternary complex transcription factors
Buchwalter, G., Gross, C., & Wasylyk, B. (2004) · Gene · doi:10.1016/j.gene.2003.09.028 · Cited by 336 · cited 1×
“Phosphorylation of Elk-1 by ERK or RSK, an ERK-regulated kinase, induces Elk-1 binding to SRF, and thereby results in an increase in SRF transcriptional activity (Buchwalter et al., 2004).”
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Cited by
An optimized optogenetic clustering tool for probing protein interaction and function
Taslimi, A., Vrana, J. D., Chen, D., Borinskaya, S., Mayer, B. J., Kennedy, M. J., & Tucker, C. L. (2014) · Nature Communications · doi:10.1038/ncomms5925 · Cited by 386
Functional Roles of Pulsing in Genetic Circuits
Levine, J. H., Lin, Y., & Elowitz, M. B. (2013) · Science · doi:10.1126/science.1239999 · Cited by 377
SRF Co-factors Control the Balance between Cell Proliferation and Contractility
Gualdrini, F., Esnault, C., Horswell, S., Stewart, A., Matthews, N., & Treisman, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.10.016 · Cited by 161
Panayiotou, R., Miralles, F., Pawlowski, R., Diring, J., Flynn, H. R., Skehel, M., & Treisman, R. (2016) · eLife · doi:10.7554/elife.15460 · Cited by 79
Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
Kochańczyk, M., Kocieniewski, P., Kozłowska, E., Jaruszewicz-Błońska, J., Sparta, B., Pargett, M., Albeck, J. G., Hlavacek, W. S., & Lipniacki, T. (2017) · Scientific Reports · doi:10.1038/srep38244 · Cited by 59
Metadata
- Authors
- Aoki, K., Kumagai, Y., Sakurai, A., Komatsu, N., Fujita, Y., Shionyu, C., & Matsuda, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 52
- Issue
- 4
- Pages
- 529-540
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2109067263
- Cited by
- 336
- References
- 3
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aoki, K., Kumagai, Y., Sakurai, A., Komatsu, N., Fujita, Y., Shionyu, C., & Matsuda, M. (2013). Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.09.015
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