The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin
Open accessAbstract
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not known whether a failure to silence transcription flanking DSBs has any impact on DNA repair efficiency or whether chromatin remodelers contribute to the process. Here, we show that the PBAF remodeling complex is important for DSB-induced transcriptional silencing and promotes repair of a subset of DNA DSBs at early time points, which can be rescued by inhibiting transcription globally. An ATM phosphorylation site on BAF180, a PBAF subunit, is required for both processes. Furthermore, we find that subunits of the PRC1 and PRC2 polycomb group complexes are similarly required for DSB-induced silencing and promoting repair. Cancer-associated BAF180 mutants are unable to restore these functions, suggesting PBAF's role in repressing transcription near DSBs may contribute to its tumor suppressor activity.
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Cites
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
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ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
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Self-citationRole of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene Silencing
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ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
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RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling
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A Role for Small RNAs in DNA Double-Strand Break Repair
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Cited by
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Hodges, C., Kirkland, J. G., & Crabtree, G. R. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026930 · Cited by 414
Michelini, F., Pitchiaya, S., Vitelli, V., Sharma, S., Gioia, U., Pessina, F., Cabrini, M., Wang, Y., Capozzo, I., Iannelli, F., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3643 · Cited by 392
Gong, F., Chiu, L.-Y., Cox, B., Aymard, F., Clouaire, T., Leung, J. W., Cammarata, M., Perez, M., Agarwal, P., Brodbelt, J. S., et al. (2015) · Genes & Development · doi:10.1101/gad.252189.114 · Cited by 247
Epigenome Maintenance in Response to DNA Damage
Dabin, J., Fortuny, A., & Polo, S. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.006 · Cited by 161
Zhang, Y., Chang, J.-F., Sun, J., Chen, L., Yang, X.-M., Tang, H.-Y., Jing, Y.-Y., Kang, X., He, Z.-M., Wu, J.-Y., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.215525 · Cited by 45
Metadata
- Authors
- Kakarougkas, A., Ismail, A., Chambers, A. L., Riballo, E., Herbert, A. D., Künzel, J., Löbrich, M., Jeggo, P. A., & Downs, J. A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 55
- Issue
- 5
- Pages
- 723-732
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2054646144
- Cited by
- 290
- References
- 27
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin. https://app.cochat.ai/papers/10.1016/j.molcel.2014.06.028
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- Kakarougkas, A., Ismail, A., Chambers, A. L., Riballo, E., Herbert, A. D., Künzel, J., Löbrich, M., Jeggo, P. A., & Downs, J. A. (2014). Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin. Molecular Cell. https://doi.org/10.1016/j.molcel.2014.06.028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
