The DOI matches its Crossref record; 218 of the 218 references it cites were found in a registry or an index.
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Open accessAbstract
During the last decade, a host of epigenetic mechanisms were found to contribute to cancer and other human diseases. Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated complexes in cancer. Recurrent mutations arise in genes encoding several BAF/PBAF subunits, including ARID1A, ARID2, PBRM1, SMARCA4, and SMARCB1 These subunits share some degree of conservation with subunits from related adenosine triphosphate (ATP)-dependent chromatin remodeling complexes in model organisms, in which a large body of work provides insight into their roles in cancer. Here, we review the roles of BAF- and PBAF-like complexes in these organisms, and relate these findings to recent discoveries in cancer epigenomics. We review several roles of BAF and PBAF complexes in cancer, including transcriptional regulation, DNA repair, and regulation of chromatin architecture and topology. More recent results highlight the need for new techniques to study these complexes.
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Citations
Cites
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Cited by
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“Genes encoding other SWI/SNF complex members, most notably ARID1A/B, are among themost frequentlymutated in all human cancers (36).”
BackgroundGenome Regulation by Polycomb and Trithorax: 70 Years and Counting
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Metadata
- Authors
- Hodges, C., Kirkland, J. G., & Crabtree, G. R.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-07-13
- Volume
- 6
- Issue
- 8
- Pages
- a026930
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2460529418
- Cited by
- 414
- References
- 218
- Type
- posted content
- Language
- en
- Open access
- bronze
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