The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity
Open accessAbstract
Three-dimensional cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has recently undergone a quantum leap progression in its achievable resolution and its applicability to the study of challenging biological systems. Because crystallization is not required, only small amounts of sample are needed, and, because images can be classified in a computer, the technique has the potential to deal with compositional and conformational mixtures. Therefore, cryo-EM can be used to investigate complete and fully functional macromolecular complexes in different functional states, providing a richness of biological insight. In this review we underlie some of the principles behind the cryo-EM methodology of single particle analysis and discuss some recent results of its application to challenging systems of paramount biological importance. We place special emphasis on new methodological developments that are leading to an explosion of new studies, many of which are reaching resolutions that could only be dreamed of only a couple of years ago.
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Cites
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
Scheres, S. H. W. (2012) · Journal of Structural Biology · doi:10.1016/j.jsb.2012.09.006 · Cited by 5,446
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Complete subunit architecture of the proteasome regulatory particle
Lander, G. C., Estrin, E., Matyskiela, M. E., Bashore, C., Nogales, E., & Martin, A. (2012) · Nature · doi:10.1038/nature10774 · Cited by 608
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Cited by
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Li, T., Nowell, C. J., Cipolla, D., Rades, T., & Boyd, B. J. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01308 · Cited by 57
Integrative Structural Biology in the Era of Accurate Structure Prediction
Masrati, G., Landau, M., Ben-Tal, N., Lupas, A., Kosloff, M., & Kosinski, J. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167127 · Cited by 53
Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins
Strickland, M. R., Rau, M. J., Summers, B., Basore, K., Wulf, J., Jiang, H., Chen, Y., Ulrich, J. D., Randolph, G. J., Zhang, R., et al. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.018 · Cited by 28
Amani, K., Shivnauth, V., & Castroverde, C. D. M. (2023) · Plant Direct · doi:10.1002/pld3.509 · Cited by 5
From Signal to Symphony: Exploring 2D Sequence Representations for Protein Function Prediction
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Metadata
- Authors
- Nogales, E., & Scheres, S. H. W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 58
- Issue
- 4
- Pages
- 677-689
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1520649887
- Cited by
- 378
- References
- 6
- FWCI
- 16.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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