The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
SRSF1-Regulated Alternative Splicing in Breast Cancer
Open accessAbstract
Summary Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated alternative splicing (AS) targets in organotypic three-dimensional MCF-10A cell cultures that mimic a context relevant to breast cancer. We identified and validated hundreds of endogenous SRSF1-regulated AS events. De-novo discovery of the SRSF1 binding motif reconciled discrepancies in previous motif analyses. Using a Bayesian model, we determined positional effects of SRSF1 binding on cassette exons: binding close to the 5′ splice site generally promoted exon inclusion, whereas binding near the 3′ splice site promoted either exon skipping or inclusion. Finally, we identified SRSF1-regulated AS events deregulated in human tumors; overexpressing one such isoform, exon-9-included CASC4, increased acinar size and proliferation, and decreased apoptosis, partially recapitulating SRSF1's oncogenic effects. Thus, we uncovered SRSF1 positive and negative regulatory mechanisms, and oncogenic AS events that represent potential targets for therapeutics development.
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Cites
Frequent pathway mutations of splicing machinery in myelodysplasia
Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029
A compendium of RNA-binding motifs for decoding gene regulation
Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480 · cited 4×
“The published SRSF1 motifs do agree in many respects, such as the general preference for purines or the occurrence of AGGA in the consensus (Pandit et al., 2013; Ray et al., 2013; Sanford et al., 2009; Smith et al., 2006; Tacke and Manley, 1995).”
InfluentialHITS-CLIP yields genome-wide insights into brain alternative RNA processing
Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature · doi:10.1038/nature07488 · Cited by 1,352 · cited 4×
“The main differences between our regulatory maps and previous ones (Huelga et al., 2012; Licatalosi et al., 2008; Pandit et al., 2013) are that: (1) our model reports probabilities, rather than density units, because they are more intuitive; (2) whereas previous studies report background models as…”
InfluentialSplicing factor mutations and cancer
Yoshida, K., & Ogawa, S. (2014) · WIREs RNA · doi:10.1002/wrna.1222 · Cited by 155
Cited by
RNA splicing dysregulation and the hallmarks of cancer
Bradley, R. K., & Anczuków, O. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00541-7 · Cited by 579
Self-citationTherapeutic targeting of splicing in cancer
Lee, S. C.-W., & Abdel-Wahab, O. (2016) · Nature Medicine · doi:10.1038/nm.4165 · Cited by 561
Urbanski, L. M., Leclair, N., & Anczuków, O. (2018) · WIREs RNA · doi:10.1002/wrna.1476 · Cited by 389
Self-citationMisregulation of alternative splicing in a mouse model of Rett syndrome
Li, R., Dong, Q., Yuan, X., Zeng, X., Gao, Y., Chiao, C., Li, H., Zhao, X., Keles, S., Wang, Z., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006129 · Cited by 67
Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer
Li, Y., Guo, H., Jin, C., Qiu, C., Gao, M., Zhang, L., Liu, Z., & Kong, B. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.008 · Cited by 28
Metadata
- Authors
- Anczuków, O., Akerman, M., Cléry, A., Wu, J., Shen, C., Shirole, N. H., Raimer, A., Sun, S., Jensen, M. A., Hua, Y., Allain, F. H.-T., & Krainer, A. R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 60
- Issue
- 1
- Pages
- 105-117
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1829675031
- Cited by
- 367
- References
- 4
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Anczuków, O., Akerman, M., Cléry, A., Wu, J., Shen, C., Shirole, N. H., Raimer, A., Sun, S., Jensen, M. A., Hua, Y., Allain, F. H.-T., & Krainer, A. R. (2015). SRSF1-Regulated Alternative Splicing in Breast Cancer. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.09.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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