Splicing factor mutations and cancer

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078 · see citing works

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665 · see citing works

Listening to silence and understanding nonsense: exonic mutations that affect splicing

Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics · doi:10.1038/nrg775 · Cited by 2,209 · see citing works

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058 · see citing works

Frequent pathway mutations of splicing machinery in myelodysplasia

Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029 · see citing works

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-518886 · Cited by 1,832 · see citing works

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works

Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>

Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756 · see citing works

The landscape of cancer genes and mutational processes in breast cancer

Stephens, P. J., Tarpey, P. S., Davies, H. R., Loo, P. V., Greenman, C., Wedge, D. C., Nik‐Zainal, S., Martin, S., Varela, I., Bignell, G. R., et al. (2012) · Nature · doi:10.1038/nature11017 · Cited by 1,686 · see citing works

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

Haferlach, T., Nagata, Y., Grossmann, V, Okuno, Y., Bacher, U., Nagae, G., Schnittger, S., Sanada, M., Kon, A., Alpermann, T., et al. (2014) · Leukemia · doi:10.1038/leu.2013.336 · Cited by 1,532 · see citing works

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

Landau, D. A., Carter, S. L., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M. S., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.019 · Cited by 1,379 · see citing works

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284 · see citing works

Somatic<i>SF3B1</i>Mutation in Myelodysplasia with Ring Sideroblasts

Papaemmanuil, E., Cazzola, M., Boultwood, J., Malcovati, L., Vyas, P., Bowen, D., Pellagatti, A., Wainscoat, J. S., Hellstrom-Lindberg, E., Gambacorti-Passerini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103283 · Cited by 1,222 · see citing works

RNA and Disease

Cooper, T. A., Wan, L., & Dreyfuss, G. (2009) · Cell · doi:10.1016/j.cell.2009.02.011 · Cited by 1,160 · see citing works

SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

Wang, L., Lawrence, M. S., Wan, Y., Stojanov, P., Sougnez, C. L., Stevenson, K. E., Werner, L. L., Sivachenko, A., DeLuca, D. S., Zhang, L., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1109016 · Cited by 1,081 · see citing works

Splicing in disease: disruption of the splicing code and the decoding machinery

Wang, G., & Cooper, T. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2164 · Cited by 1,040 · see citing works

Whole-genome analysis informs breast cancer response to aromatase inhibition

Ellis, M. J., Ding, L., Shen, D., Luo, J. R., Suman, V. J., Wallis, J. W., Tine, B. A. V., Hoog, J., Goiffon, R., Goldstein, T. C., et al. (2012) · Nature · doi:10.1038/nature11143 · Cited by 1,023 · see citing works

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Quesada, V., Conde, L., Villamor, N., Ordóñez, G. R., Jares, P., Bassaganyas, L., Ramsay, A. J., Beà, S., Pinyol, M., Martínez‐Trillos, A., et al. (2011) · Nature Genetics · doi:10.1038/ng.1032 · Cited by 987 · see citing works

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

Karni, R., de Stanchina, E., Lowe, S. W., Sinha, R., Mu, D., & Krainer, A. R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1209 · Cited by 935 · see citing works

Alternative splicing: a pivotal step between eukaryotic transcription and translation

Kornblihtt, A. R., Schor, I. E., Alló, M., Dujardin, G., Petrillo, E., & Muñoz, M. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3525 · Cited by 851 · see citing works

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhingedPreprint

David, C. J., & Manley, J. L. (2010) · Genes & Development · doi:10.1101/gad.1973010 · Cited by 815 · see citing works

Epigenetics in Alternative Pre-mRNA Splicing

Luco, R. F., Alló, M., Schor, I. E., Kornblihtt, A. R., & Misteli, T. (2011) · Cell · doi:10.1016/j.cell.2010.11.056 · Cited by 783 · see citing works

Mutations and prognosis in primary myelofibrosis

Vannucchi, A. M., Lasho, T. L., Guglielmelli, P., Biamonte, F., Pardanani, A. D., Pereira, A., Finke, C. M., Score, J., Gangat, N., Mannarelli, C., et al. (2013) · Leukemia · doi:10.1038/leu.2013.119 · Cited by 770 · see citing works

Myelodysplastic Syndromes

Tefferi, A., & Vardiman, J. W. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0902908 · Cited by 669 · see citing works

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Kaida, D., Motoyoshi, H., Tashiro, E., Nojima, T., Hagiwara, M., Ishigami, K., Watanabe, H., Kitahara, T., Yoshida, T., Nakajima, H., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.18 · Cited by 652 · see citing works

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Kotake, Y., Sagane, K., Owa, T., Mimori‐Kiyosue, Y., Shimizu, H., Uesugi, M., Ishihama, Y., Iwata, M., & Mizui, Y. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.16 · Cited by 648 · see citing works

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

Graubert, T. A., Shen, D., Ding, L., Okeyo-Owuor, T., Shirai, C. L., Shao, J., Krysiak, K., Harris, C. C., Koboldt, D. C., Larson, D. E., et al. (2011) · Nature Genetics · doi:10.1038/ng.1031 · Cited by 582 · see citing works

Prognostic Score Including Gene Mutations in Chronic Myelomonocytic Leukemia

Itzykson, R., Kosmider, O., Renneville, A., Gelsi‐Boyer, V., Meggendorfer, M., Morabito, M., Berthon, C., Adès, L., Fenaux, P., Beyne‐Rauzy, O., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.3314 · Cited by 546 · see citing works

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

Martin, M., Maßhöfer, L., Ketteler, P., Rahmann, S., Metz, C. H. D., Bornfeld, N., van de Nes, J. A. P., Klein‐Hitpaß, L., Hinnebusch, A. G., Horsthemke, B., et al. (2013) · Nature Genetics · doi:10.1038/ng.2674 · Cited by 536 · see citing works

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

Harbour, J. W., Roberson, E. D. O., Anbunathan, H., Onken, M. D., Worley, L. A., & Bowcock, A. M. (2013) · Nature Genetics · doi:10.1038/ng.2523 · Cited by 517 · see citing works

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Malcovati, L., Papaemmanuil, E., Bowen, D., Boultwood, J., Porta, M. G. D., Pascutto, C., Travaglino, E., Groves, M. J., Godfrey, A. L., Ambaglio, I., et al. (2011) · Blood · doi:10.1182/blood-2011-09-377275 · Cited by 496 · see citing works

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

Rossi, D., Rasi, S., Spina, V., Bruscaggin, A., Monti, S. M., Ciardullo, C., Deambrogi, C., Khiabanian, H., Serra, R., Bertoni, F., et al. (2012) · Blood · doi:10.1182/blood-2012-09-458265 · Cited by 467 · see citing works

Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes

Bejar, R. L., Stevenson, K. E., Caughey, B. A., Abdel-Wahab, O. I., Steensma, D. P., Galili, N., Raza, A., Kantarjian, H. M., Levine, R. L., Neuberg, D. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7379 · Cited by 442 · see citing works

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

Furney, S. J., Pedersen, M., Gentien, D., Dumont, A. G., Rapinat, A., Desjardins, L., Turajlic, S., Piperno-Neumann, S., de la Grange, P., Roman‐Roman, S., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0330 · Cited by 435 · see citing works

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

Thol, F. R., Kade, S., Schlarmann, C., Löffeld, P., Morgan, M. A., Krauter, J., Włodarski, M. W., Kölking, B., Wichmann, M., Görlich, K., et al. (2012) · Blood · doi:10.1182/blood-2011-12-399337 · Cited by 420 · see citing works

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness

Rossi, D., Bruscaggin, A., Spina, V., Rasi, S., Khiabanian, H., Messina, M., Fangazio, M., Vaisitti, T., Monti, S. M., Chiaretti, S., et al. (2011) · Blood · doi:10.1182/blood-2011-08-373159 · Cited by 372 · see citing works

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis

Makishima, H., Visconte, V., Sakaguchi, H., Jankowska, A. M., Kar, S. A., Jerez, A., Przychodzen, B. P., Bupathi, M., Guinta, K. M., Afable, M. G., et al. (2012) · Blood · doi:10.1182/blood-2011-12-399774 · Cited by 368 · see citing works

The splicing factor SC35 has an active role in transcriptional elongation

Lin, S., Coutinho-Mansfield, G., Wang, D., Pandit, S., & Fu, X. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1461 · Cited by 363 · see citing works

The significant other: splicing by the minor spliceosome

Turunen, J. J., Niemelä, E. H., Verma, B., & Frilander, M. J. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1141 · Cited by 349 · see citing works

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

Meggendorfer, M., Roller, A., Haferlach, T., Eder, C., Dicker, F., Grossmann, V., Kohlmann, A., Alpermann, T., Yoshida, K., Ogawa, S., et al. (2012) · Blood · doi:10.1182/blood-2012-01-404863 · Cited by 309 · see citing works

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

Walter, M. J., Shen, D., Shao, J., Ding, L., White, B. S., Kandoth, C., Miller, C. A., Niu, B., McLellan, M. D., Dees, N. D., et al. (2013) · Leukemia · doi:10.1038/leu.2013.58 · Cited by 284 · see citing works

Clonal architecture of chronic myelomonocytic leukemias

Itzykson, R., Kosmider, O., Renneville, A., Morabito, M., Preudhomme, C., Berthon, C., Adès, L., Fenaux, P., Platzbecker, U., Gagey, O., et al. (2013) · Blood · doi:10.1182/blood-2012-06-440347 · Cited by 276 · see citing works

High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias

Waterfall, J. J., Arons, E., Walker, R. L., Pineda, M. A., Roth, L., Killian, J. K., Abaan, O. D., Davis, S. R., Kreitman, R. J., & Meltzer, P. S. (2013) · Nature Genetics · doi:10.1038/ng.2828 · Cited by 274 · see citing works

Whole exome sequencing of adenoid cystic carcinoma

Stephens, P. J., Davies, H. R., Mitani, Y., Loo, P. V., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Cheverton, A., Bignell, G. R., Butler, A. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67201 · Cited by 270 · see citing works

Comprehensive mutational profiling in advanced systemic mastocytosis

Schwaab, J., Schnittger, S., Sotlar, K., Walz, C., Fabarius, A. C., Pfirrmann, M., Kohlmann, A., Großmann, V., Meggendorfer, M., Horny, H., et al. (2013) · Blood · doi:10.1182/blood-2013-04-496448 · Cited by 262 · see citing works

Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I

He, H., Liyanarachchi, S., Akagi, K., Nagy, R. S., Li, J., Dietrich, R. C., Li, W., Sebastian, N., Wen, B., Xin, B., et al. (2011) · Science · doi:10.1126/science.1200587 · Cited by 262 · see citing works

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes

Damm, F., Kosmider, O., Gelsi‐Boyer, V., Renneville, A., Carbuccia, N., Hidalgo-Curtis, C., Della-Valle, V., Couronné, L., Scourzic, L., Chesnais, V., et al. (2012) · Blood · doi:10.1182/blood-2011-12-400994 · Cited by 232 · see citing works

Haploinsufficiency of SF3B4, a Component of the Pre-mRNA Spliceosomal Complex, Causes Nager Syndrome

Bernier, F. P., Caluseriu, O., Ng, S. B. H., Schwartzentruber, J., Buckingham, K. J., Innes, A. M., Jabs, E. W., Innis, J. W., Schuette, J. L., Gorski, J. L., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.04.004 · Cited by 228 · see citing works

Association of TALS Developmental Disorder with Defect in Minor Splicing Component U4atac snRNA

Edery, P., Marcaillou, C., Sahbatou, M., Labalme, A., Chastang, J., Touraine, R. L., Tubacher, E., Senni, F., Bober, M. B., Nampoothiri, S., et al. (2011) · Science · doi:10.1126/science.1202205 · Cited by 228 · see citing works

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

Zhang, S.-J., Rampal, R. K., Manshouri, T., Patel, J. L., Mensah, N. Y., Kayserian, A., Hricik, T., Heguy, A., Hedvat, C. V., Gönen, M., et al. (2012) · Blood · doi:10.1182/blood-2011-11-390252 · Cited by 218 · see citing works

The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial

Oscier, D. G., Rose-Zerilli, M. J. J., Winkelmann, N., de Castro, D. G., Gomez, B., Forster, J., Parker, H., Parker, A. E., Gardiner, A. C., Collins, A. R., et al. (2012) · Blood · doi:10.1182/blood-2012-05-429282 · Cited by 212 · see citing works

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

Visconte, V., Makishima, H., Jankowska, A. M., Szpurka, H., Traina, F., Jerez, A., O'Keefe, C., Rogers, H. J., Sekeres, M. A., Maciejewski, J. P., et al. (2011) · Leukemia · doi:10.1038/leu.2011.232 · Cited by 212 · see citing works

SF3B1 mutations are prevalent in myelodysplastic syndromes with ring sideroblasts but do not hold independent prognostic value

Patnaik, M. M., Lasho, T. L., Hodnefield, J. M., Knudson, R. A., Ketterling, R. P., Garcia‐Manero, G., Steensma, D. P., Pardanani, A. D., Hanson, C. A., & Tefferi, A. (2011) · Blood · doi:10.1182/blood-2011-09-377994 · Cited by 201 · see citing works

Synthetic lethality: exploiting the addiction of cancer to DNA repair

Shaheen, M. F., Allen, C., Nickoloff, J. A., & Hromas, R. (2011) · Blood · doi:10.1182/blood-2011-01-313734 · Cited by 200 · see citing works

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

Visconte, V., Rogers, H. J., Singh, J., Barnard, J., Bupathi, M., Traina, F., McMahon, J. T., Makishima, H., Szpurka, H., Jankowska, A. M., et al. (2012) · Blood · doi:10.1182/blood-2012-05-430876 · Cited by 179 · see citing works

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

Fan, L., Lagisetti, C., Edwards, C. C., Webb, T. R., & Potter, P. M. (2011) · ACS Chemical Biology · doi:10.1021/cb100356k · Cited by 167 · see citing works

SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival

Lasho, T. L., Jimma, T., Finke, C. M., Patnaik, M. M., Hanson, C. A., Ketterling, R. P., Pardanani, A. D., & Tefferi, A. (2012) · Blood · doi:10.1182/blood-2012-05-429696 · Cited by 166 · see citing works

Insights into the connection between cancer and alternative splicing

Kim, E., Goren, A., & Ast, G. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.001 · Cited by 162 · see citing works

Splicing Regulator SC35 Is Essential for Genomic Stability and Cell Proliferation during Mammalian Organogenesis

Xiao, R., Sun, Y., Ding, J., Lin, S., Rose, D. W., Rosenfeld, M. G., Fu, X., & Li, X. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00288-07 · Cited by 159 · see citing works

Spliceosome mutations involving SRSF2, SF3B1, and U2AF35 in chronic myelomonocytic leukemia: Prevalence, clinical correlates, and prognostic relevance

Patnaik, M. M., Lasho, T. L., Finke, C. M., Hanson, C. A., Hodnefield, J. M., Knudson, R. A., Ketterling, R. P., Pardanani, A. D., & Tefferi, A. (2012) · American Journal of Hematology · doi:10.1002/ajh.23373 · Cited by 154 · see citing works

The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution

Wu, S., Kuo, Y., Hou, H., Li, L.-Y., Tseng, M., Huang, C., Lee, F., Liu, M.-C., Liu, C., Lin, C., et al. (2012) · Blood · doi:10.1182/blood-2012-02-412296 · Cited by 153 · see citing works

Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms

Cazzola, M., Rossi, M., & Malcovati, L. (2012) · Blood · doi:10.1182/blood-2012-09-399725 · Cited by 151 · see citing works

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms

Przychodzen, B. P., Jerez, A., Guinta, K. M., Sekeres, M. A., Padgett, R. A., Maciejewski, J. P., & Makishima, H. (2013) · Blood · doi:10.1182/blood-2013-01-480970 · Cited by 149 · see citing works

SF3B1 mutations in chronic lymphocytic leukemia

Wan, Y., & Wu, C. J. (2013) · Blood · doi:10.1182/blood-2013-02-427641 · Cited by 145 · see citing works

Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5

Fushimi, K., Ray, P., Kar, A. N., Wang, L., Sutherland, L. C., & Wu, J. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805569105 · Cited by 140 · see citing works

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia

Shih, A. H., Chung, S. S., Dolezal, E. K., Zhang, S.-J., Abdel-Wahab, O. I., Park, C. Y., Nimer, S. D., Levine, R. L., & Klimek, V. M. (2013) · Haematologica · doi:10.3324/haematol.2012.076729 · Cited by 135 · see citing works

SF3B1 mutations in primary myelofibrosis: clinical, histopathology and genetic correlates among 155 patients

Lasho, T. L., Finke, C. M., Hanson, C. A., Jimma, T., Knudson, R. A., Ketterling, R. P., Pardanani, A. D., & Tefferi, A. (2011) · Leukemia · doi:10.1038/leu.2011.320 · Cited by 117 · see citing works

Mammalian Polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1Preprint

Isono, K., Mizutani-Koseki, Y., Komori, T., Schmidt-Zachmann, M. S., & Koseki, H. (2005) · Genes & Development · doi:10.1101/gad.1284605 · Cited by 110 · see citing works

Meayamycin inhibits pre–messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells

Albert, B. J., McPherson, P. A., O'Brien, K., Czaicki, N. L., DeStefino, V. J., Osman, S., Li, M., Day, B. W., Grabowski, P. J., Moore, M. J., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0051 · Cited by 99 · see citing works

The U2AF35-related protein Urp contacts the 3′ splice site to promote U12-type intron splicing and the second step of U2-type intron splicingPreprint

Shen, H., Zheng, X., Luecke, S., & Green, M. R. (2010) · Genes & Development · doi:10.1101/gad.1974810 · Cited by 97 · see citing works

Age, JAK2V617F and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis

Broséus, J., Alpermann, T., Wulfert, M., Florensa, L., Jeromin, S., Lippert, É., Rozman, M., Lifermann, F., Großmann, V., Haferlach, T., et al. (2013) · Leukemia · doi:10.1038/leu.2013.120 · Cited by 94 · see citing works

Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF 35 and for Its Function after Polypyrimidine Tract Recognition by U2AF 65

Guth, S., Martínez, C., Gaur, R. K., & Valcárcel, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8263 · Cited by 89 · see citing works

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

Damm, F., Thol, F. R., Kosmider, O., Kade, S., Löffeld, P., Dreyfus, F., Stamatoullas, A., Schmidt, A., Beyne‐Rauzy, O., de Botton, S., et al. (2011) · Leukemia · doi:10.1038/leu.2011.321 · Cited by 81 · see citing works

Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome

Mian, S. A., Smith, A., Kulasekararaj, A. G., Kizilors, A., Mohamedali, A. M., Lea, N. C., Mitsopoulos, C., Ford, K., Nasser, E. E., Seidl, T., et al. (2013) · Haematologica · doi:10.3324/haematol.2012.075325 · Cited by 77 · see citing works

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML

Hirabayashi, S., Flotho, C., Moetter, J., Heuser, M., Hasle, H., Gruhn, B., Klingebiel, T. E., Thol, F. R., Schlegelberger, B., Baumann, I., et al. (2012) · Blood · doi:10.1182/blood-2011-12-395087 · Cited by 71 · see citing works

Mutational analysis of splicing machinery genes SF3B1, U2AF1 and SRSF2 in myelodysplasia and other common tumors

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Defects in spliceosomal machinery: a new pathway of leukaemogenesis

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