The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Measuring In Vivo Mitophagy
Open accessAbstract
Summary Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of the fluorescent reporter Keima (mt-Keima). Keima is a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases. Comparison of a wide range of primary cells and tissues generated from the mt-Keima mouse revealed significant variations in basal mitophagy. In addition, we have employed the mt-Keima mice to analyze how mitophagy is altered by conditions including diet, oxygen availability, Huntingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in mitochondrial mutational load, the presence of metastatic tumors and normal aging. The ability to assess mitophagy under a host of varying environmental and genetic perturbations suggests that the mt-Keima mouse should be a valuable resource.
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Self-citationPremature ageing in mice expressing defective mitochondrial DNA polymerase
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Self-citationMitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
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The mitochondrial basis of aging
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Self-citationMitochondrial Dynamics and Its Involvement in Disease
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Metadata
- Authors
- Sun, N., Yun, J., Liu, J., Malide, D., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., & Finkel, T.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 60
- Issue
- 4
- Pages
- 685-696
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2099981888
- Cited by
- 692
- References
- 18
- FWCI
- 30.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, N., Yun, J., Liu, J., Malide, D., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., & Finkel, T. (2015). Measuring In Vivo Mitophagy. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.10.009
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