Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Parkinson's disease

Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,412 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

TFEB Links Autophagy to Lysosomal Biogenesis

Settembre, C., Di Malta, C., Polito, V. A., Arencibia, M. G., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., et al. (2011) · Science · doi:10.1126/science.1204592 · Cited by 3,365 · see citing works

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774 · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310 · see citing works

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

Garcia, D., & Shaw, R. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.032 · Cited by 1,997 · see citing works

The Role of Mitochondria in Apoptosis

Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987 · see citing works

On the origin of mitosing cells

Sagan, L. (1967) · Journal of Theoretical Biology · doi:10.1016/0022-5193(67)90079-3 · Cited by 1,870 · see citing works

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570 · see citing works

Ubiquitin is phosphorylated by PINK1 to activate parkin

Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., et al. (2014) · Nature · doi:10.1038/nature13392 · Cited by 1,477 · see citing works

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008084 · Cited by 1,375 · see citing works

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007013 · Cited by 1,369 · see citing works

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342 · see citing works

Nix is a selective autophagy receptor for mitochondrial clearance

Novak, I., Kirkin, V., McEwan, D. G., Zhang, J., Wild, P., Rozenknop, A., Rogov, V., Löhr, F., Popovic, D., Occhipinti, A., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2009.256 · Cited by 1,309 · see citing works

Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, C., et al. (2011) · Science · doi:10.1126/science.1205405 · Cited by 1,298 · see citing works

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Kane, L. A., Lazarou, M., Fogel, A. I., Li, Y., Yamano, K., Sarraf, S. A., Banerjee, S., & Youle, R. J. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201402104 · Cited by 1,298 · see citing works

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works

Cargo recognition and trafficking in selective autophagy

Stolz, A., Ernst, A., & Dikic, I. (2014) · Nature Cell Biology · doi:10.1038/ncb2979 · Cited by 1,207 · see citing works

Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203 · see citing works

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature · doi:10.1038/nature07006 · Cited by 1,185 · see citing works

Proteasomal and Autophagic Degradation Systems

Đikić, I. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-044908 · Cited by 1,165 · see citing works

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085 · see citing works

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works

Mitonuclear protein imbalance as a conserved longevity mechanism

Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W., & Auwerx, J. (2013) · Nature · doi:10.1038/nature12188 · Cited by 1,035 · see citing works

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Nargund, A. M., Pellegrino, M., Fiorese, C. J., Baker, B. M., & Haynes, C. M. (2012) · Science · doi:10.1126/science.1223560 · Cited by 1,027 · see citing works

A mitochondrial specific stress response in mammalian cells

Zhao, Q., Wang, J., Levichkin, I. V., Stasinopoulos, S., Ryan, M. T., & Hoogenraad, N. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf445 · Cited by 1,026 · see citing works

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Settembre, C., De Cegli, R., Mansueto, G., Saha, P. K., Vetrini, F., Visvikis, O., Huynh, T., Carissimo, A., Palmer, D., Jürgen Klisch, T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2718 · Cited by 1,022 · see citing works

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1

Baar, K., Wende, A. R., Jones, T. E., Marison, M., Nolte, L. A., Chen, M., Kelly, D. P., & Holloszy, J. O. (2002) · The FASEB Journal · doi:10.1096/fj.02-0367com · Cited by 1,020 · see citing works

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

Sarraf, S. A., Raman, M., Guarani, V., Sowa, M. E., Huttlin, E. L., Gygi, S. P., & Harper, J. W. (2013) · Nature · doi:10.1038/nature12043 · Cited by 1,020 · see citing works

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953 · see citing works

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

Kondapalli, C., Kazlauskaite, A., Zhang, N., Woodroof, H. I., Campbell, D. G., Gourlay, R., Burchell, L., Walden, H., Macartney, T. J., Deak, M., et al. (2012) · Open Biology · doi:10.1098/rsob.120080 · Cited by 940 · see citing works

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

Schweers, R. L., Zhang, J., Randall, M. S., Loyd, M. R., Li, W., Dorsey, F. C., Kundu, M., Opferman, J. T., Cleveland, J. L., Miller, J. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708818104 · Cited by 939 · see citing works

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Heo, J.-M., Ordureau, A., Paulo, J. A., Rinehart, J., & Harper, J. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.016 · Cited by 906 · see citing works

Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle

Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885 · see citing works

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 884 · see citing works

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

Okamoto, K., Kondo‐Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 867 · see citing works

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Wei, Y., Chiang, W., Sumpter, R., Mishra, P., & Levine, B. (2016) · Cell · doi:10.1016/j.cell.2016.11.042 · Cited by 853 · see citing works

TFEB at a glance

Napolitano, G., & Ballabio, A. (2016) · Journal of Cell Science · doi:10.1242/jcs.146365 · Cited by 836 · see citing works

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Quirós, P. M., Prado, M. A., Zamboni, N., D’Amico, D., Williams, R. W., Finley, D., Gygi, S. P., & Auwerx, J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201702058 · Cited by 832 · see citing works

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Wong, Y. C., & Holzbaur, E. L. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405752111 · Cited by 812 · see citing works

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M., & Muqit, M. M. K. (2014) · Biochemical Journal · doi:10.1042/bj20140334 · Cited by 806 · see citing works

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

Kanki, T., Wang, K., Cao, Y., Baba, M., & Klionsky, D. J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.014 · Cited by 798 · see citing works

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

Narendra, D. P., Kane, L. A., Hauser, D. N., Fearnley, I. M., & Youle, R. J. (2010) · Autophagy · doi:10.4161/auto.6.8.13426 · Cited by 789 · see citing works

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

Bruick, R. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9082 · Cited by 767 · see citing works

Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy

Hanna, R. A., Quinsay, M. N., Orogo, A. M., Giang, K., Rikka, S., & Gustafsson, Å. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322933 · Cited by 762 · see citing works

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

Soubannier, V., McLelland, G., Zunino, R., Braschi, E., Rippstein, P. U., Fon, E. A., & McBride, H. M. (2012) · Current Biology · doi:10.1016/j.cub.2011.11.057 · Cited by 755 · see citing works

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Richter, B., Sliter, D. A., Herhaus, L., Stolz, A., Wang, C., Beli, P., Zaffagnini, G., Wild, P., Martens, S., Wagner, S. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523926113 · Cited by 755 · see citing works

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

McLelland, G., Soubannier, V., Chen, C. X., McBride, H. M., & Fon, E. A. (2014) · The EMBO Journal · doi:10.1002/embj.201385902 · Cited by 743 · see citing works

HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

Sowter, H., Ratcliffe, P. J., Watson, P. H., Greenberg, A. H., & Harris, A. L. (2001) · PubMed · Cited by 711 · see citing works

Measuring In Vivo Mitophagy

Sun, N., Yun, J., Liu, J., Malide, D. A., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.009 · Cited by 696 · see citing works

Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle

Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694 · see citing works

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

Ordureau, A., Sarraf, S. A., Duda, D. M., Heo, J., Jedrychowski, M. P., Sviderskiy, V. O., Olszewski, J. L., Koerber, J. T., Xie, T., Beausoleil, S. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.007 · Cited by 693 · see citing works

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Fiorese, C. J., Schulz, A. M., Lin, Y., Rosin, N., Pellegrino, M. W., & Haynes, C. M. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.002 · Cited by 672 · see citing works

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.014 · Cited by 670 · see citing works

PINK1 is degraded through the N-end rule pathway

Yamano, K., & Youle, R. J. (2013) · Autophagy · doi:10.4161/auto.24633 · Cited by 669 · see citing works

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

Katayama, H., Kogure, T., Mizushima, N., Yoshimori, T., & Miyawaki, A. (2011) · Chemistry &amp; Biology · doi:10.1016/j.chembiol.2011.05.013 · Cited by 650 · see citing works

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

Nguyen, T. N., Padman, B. S., Usher, J. L., Oorschot, V. M. J., Ramm, G., & Lazarou, M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201607039 · Cited by 649 · see citing works

Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

Hamacher-Brady, A., Brady, N. R., Logue, S. E., Sayen, M. R., Jinno, M., Kirshenbaum, L. A., Gottlieb, R. A., & Gustafsson, Å. B. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4401936 · Cited by 609 · see citing works

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

Ekstrand, M. I., Terzioglu, M., Galter, D., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F. S., Trifunovic, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605208103 · Cited by 605 · see citing works

ClpP Mediates Activation of a Mitochondrial Unfolded Protein Response in C. elegans

Haynes, C. M., Petrova, K., Benedetti, C., Yang, Y., & Ron, D. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.07.016 · Cited by 595 · see citing works

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

Shiba-Fukushima, K., Imai, Y., Yoshida, S., Ishihama, Y., Kanao, T., Sato, S., & Hattori, N. (2012) · Scientific Reports · doi:10.1038/srep01002 · Cited by 577 · see citing works

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

Kundu, M., Lindsten, T., Yang, C.-Y., Wu, J., Zhao, F., Zhang, J., Selak, M. A., Ney, P. A., & Thompson, C. B. (2008) · Blood · doi:10.1182/blood-2008-02-137398 · Cited by 571 · see citing works

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

Trempe, J.-F., Sauvé, V., Grenier, K., Seirafi, M., Tang, M. Y. H., Ménade, M., Al-Abdul-Wahid, S., Krett, J. D., Wong, K. T. K., Kozlov, G., et al. (2013) · Science · doi:10.1126/science.1237908 · Cited by 549 · see citing works

New roles for mitochondrial proteases in health, ageing and disease

Quirós, P. M., Langer, T., & López-Otı́n, C. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3984 · Cited by 546 · see citing works

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N. D., Iqbal, S., Zoncu, R., Chen, W. W., Weinberg, R. A., & Sabatini, D. M. (2015) · Science · doi:10.1126/science.1260384 · Cited by 542 · see citing works

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T. G., Prescott, A. R., Allen, G. F. G., Tamjar, J., Munson, M. J., Thomson, C., Muqit, M. M. K., & Ganley, I. G. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603039 · Cited by 541 · see citing works

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

Rawi, S. A., Louvet‐Vallée, S., Djeddi, A., Sachse, M., Culetto, E., Hajjar, C., Boyd, L., Legouis, R., & Galy, V. (2011) · Science · doi:10.1126/science.1211878 · Cited by 505 · see citing works

PINK1 cleavage at position A103 by the mitochondrial protease PARL

Deas, E., Plun‐Favreau, H., Gandhi, S., Desmond, H., Kjaer, S., Loh, S. H. Y., Renton, A. E., Harvey, R. J., Whitworth, A. J., Martins, L. M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq526 · Cited by 501 · see citing works

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival Mitophagy versus Apoptosis

Zhu, Y., Maßen, S., Terenzio, M., Lang, V., Chen-Lindner, S., Eils, R., Novak, I., Đikić, I., Hamacher‐Brady, A., & Brady, N. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.399345 · Cited by 491 · see citing works

Mechanism of phospho-ubiquitin-induced PARKIN activation

Wauer, T., Šimíček, M., Schubert, A. F., & Komander, D. (2015) · Nature · doi:10.1038/nature14879 · Cited by 479 · see citing works

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

Burman, J. L., Pickles, S., Wang, C., Sekine, S., Vargas, J. N. S., Zhang, Z., Youle, A. M., Nezich, C. L., Wu, X., Hammer, J. A., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201612106 · Cited by 479 · see citing works

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

Vincow, E. S., Merrihew, G., Thomas, R. E., Shulman, N. J., Beyer, R. P., MacCoss, M. J., & Pallanck, L. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221132110 · Cited by 478 · see citing works

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

Sato, M., & Sato, K. (2011) · Science · doi:10.1126/science.1210333 · Cited by 469 · see citing works

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

Nargund, A. M., Fiorese, C. J., Pellegrino, M. W., Deng, P., & Haynes, C. M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.008 · Cited by 463 · see citing works

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

Campbell, C. T., Kolesar, J. E., & Kaufman, B. A. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.002 · Cited by 458 · see citing works

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Wróbel, L., Topf, U., Brągoszewski, P., Wiese, S., Sztolsztener, M. E., Oeljeklaus, S., Varabyova, A., Lirski, M., Chrościcki, P., Mroczek, S., et al. (2015) · Nature · doi:10.1038/nature14951 · Cited by 458 · see citing works

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

Tsunemi, T., Ashe, T. D., Morrison, B. E., Epilepsia, K. S., Au, J., Vázquez‐Roque, R. A., Lazarowski, E. R., Damian, V. A., Masliah, E., & Spada, A. R. L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003799 · Cited by 440 · see citing works

Ubiquitinated Sperm Mitochondria, Selective Proteolysis, and the Regulation of Mitochondrial Inheritance in Mammalian Embryos1

Šutovský, P., Moreno, R. D., Ramalho‐Santos, J., et al. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.2.582 · Cited by 439 · see citing works

Uth1p Is Involved in the Autophagic Degradation of Mitochondria

Bhatia‐Kiššová, I., Deffieu, M. S., Manon, S., & Camougrand, N. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406960200 · Cited by 418 · see citing works

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

Jin, S. M., & Youle, R. J. (2013) · Autophagy · doi:10.4161/auto.26122 · Cited by 411 · see citing works

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., et al. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01426.x · Cited by 397 · see citing works

Erythropoiesis: Development and DifferentiationPreprint

Dzierzak, E., & Philipsen, S. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011601 · Cited by 388 · see citing works

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201403943 · Cited by 385 · see citing works

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

Sharpley, M. S., Marciniak, C., Eckel‐Mahan, K. L., McManus, M. J., Crimi, M., Waymire, K. G., Lin, C. S., Masubuchi, S., Friend, N., Koike, M. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.004 · Cited by 384 · see citing works

Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response

Benedetti, C., Haynes, C. M., Yang, Y., Harding, H. P., & Ron, D. (2006) · Genetics · doi:10.1534/genetics.106.061580 · Cited by 382 · see citing works

A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

Yonashiro, R., Ishido, S., Kyo, S., Fukuda, T., Gotō, E., Matsuki, Y., Ohmura‐Hoshino, M., Sada, K., Hotta, H., Yamamura, H., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601249 · Cited by 378 · see citing works

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

Meißner, C., Lorenz, H., Weihofen, A., Selkoe, D. J., & Lemberg, M. K. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07253.x · Cited by 375 · see citing works

<i>BNIP3</i> Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

Tracy, K., Dibling, B. C., Spike, B. T., Knabb, J. R., Schumacker, P., & Macleod, K. F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02246-06 · Cited by 369 · see citing works

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

Riley, B. E., Lougheed, J. C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T. A., Walker, D., Yang, Y., Regnström, K. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms2982 · Cited by 368 · see citing works

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

Wang, X., & Chen, X. J. (2015) · Nature · doi:10.1038/nature14859 · Cited by 366 · see citing works

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Hasson, S. A., Kane, L. A., Yamano, K., Huang, C.-H., Sliter, D. A., Buehler, E., Wang, C., Heman-Ackah, S. M., Hessa, T., Guha, R., et al. (2013) · Nature · doi:10.1038/nature12748 · Cited by 365 · see citing works

Mechanism of Cargo Selection in the Cytoplasm to Vacuole Targeting Pathway

Shintani, T., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00373-8 · Cited by 362 · see citing works

Analysis of proteome dynamics in the mouse brain

Price, J. C., Guan, S., Burlingame, A., Prusiner, S. B., & Ghaemmaghami, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006551107 · Cited by 357 · see citing works

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

Moore, A. S., & Holzbaur, E. L. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523810113 · Cited by 351 · see citing works

Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome.

Martinus, R., Garth, G. P., Webster, T., Cartwright, P., Naylor, D. J., Høj, P., & Hoogenraad, N. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0098h.x · Cited by 340 · see citing works

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

Rojansky, R. B., Cha, M.-Y., & Chan, D. C. (2016) · eLife · doi:10.7554/elife.17896 · Cited by 337 · see citing works

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

Suen, D., Narendra, D. P., Tanaka, A., Manfredi, G., & Youle, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914569107 · Cited by 335 · see citing works

Mitophagy in Yeast Occurs through a Selective Mechanism

Kanki, T., & Klionsky, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802403200 · Cited by 335 · see citing works

Structure of the human Parkin ligase domain in an autoinhibited state

Wauer, T., & Komander, D. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.125 · Cited by 334 · see citing works

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Pickrell, A. M., Huang, C.-H., Kennedy, S. R., Ordureau, A., Sideris, D. P., Hoekstra, J. G., Harper, J. W., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.034 · Cited by 327 · see citing works

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

Yun, J., Puri, R., Yang, H. M., Lizzio, M. A., Wu, C., Sheng, Z., & Guo, M. (2014) · eLife · doi:10.7554/elife.01958 · Cited by 325 · see citing works

Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes

Bloom, K., & Carbon, J. A. (1982) · Cell · doi:10.1016/0092-8674(82)90147-7 · Cited by 324 · see citing works

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

Matsumoto, G., Shimogori, T., Hattori, N., & Nukina, N. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv179 · Cited by 317 · see citing works

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

Münch, C., & Harper, J. W. (2016) · Nature · doi:10.1038/nature18302 · Cited by 315 · see citing works

Self-renewal of a purified Tie2 + hematopoietic stem cell population relies on mitochondrial clearance

Ito, K., Turcotte, R., Cui, J., Zimmerman, S. E., Pinho, S., Mizoguchi, T., Arai, F., Runnels, J. M., Alt, C., Teruya‐Feldstein, J., et al. (2016) · Science · doi:10.1126/science.aaf5530 · Cited by 311 · see citing works

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

Nezich, C. L., Wang, C., Fogel, A. I., & Youle, R. J. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201501002 · Cited by 309 · see citing works

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

Yamano, K., Fogel, A. I., Wang, C., van der Bliek, A. M., & Youle, R. J. (2014) · eLife · doi:10.7554/elife.01612 · Cited by 307 · see citing works

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

Wauer, T., Swatek, K. N., Wagstaff, J. L., Gladkova, C., Pruneda, J. N., Michel, M. A., Gersch, M., Johnson, C. M., Freund, S. M. V., & Komander, D. (2014) · The EMBO Journal · doi:10.15252/embj.201489847 · Cited by 303 · see citing works

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

Lin, Y., Schulz, A. M., Pellegrino, M. W., Lu, Y., Shaham, S., & Haynes, C. M. (2016) · Nature · doi:10.1038/nature17989 · Cited by 302 · see citing works

Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements

Aldridge, J. E., Horibe, T., & Hoogenraad, N. J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000874 · Cited by 299 · see citing works

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Sterky, F. H., Lee, S., Wibom, R., Olson, L., & Larsson, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103295108 · Cited by 296 · see citing works

Impairing the bioenergetic status and the biogenesis of mitochondria triggers mitophagy in yeast

Priault, M., Salin, B., Schaëffer, J., Vallette, F. M., di Rago, J.-P., & Martinou, J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401697 · Cited by 292 · see citing works

Phosphorylated ubiquitin chain is the genuine Parkin receptor

Okatsu, K., Koyano, F., Kimura, M., Kosako, H., Saeki, Y., Tanaka, K., & Matsuda, N. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201410050 · Cited by 261 · see citing works

cDNA Cloning and mRNA Analysis of PGC-1 in Epitrochlearis Muscle in Swimming-Exercised Rats

Goto, M., Terada, S., Kato, M., Katoh, M., Yokozeki, T., Tabata, I., & Shimokawa, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3134 · Cited by 258 · see citing works

Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

Karbowski, M., & Youle, R. J. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.05.007 · Cited by 256 · see citing works

Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system

McLelland, G., Lee, S., McBride, H. M., & Fon, E. A. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603105 · Cited by 253 · see citing works

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

Okatsu, K., Uno, M., Koyano, F., Go, E., Kimura, M., Oka, T., Tanaka, K., & Matsuda, N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.509653 · Cited by 248 · see citing works

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

Schwarten, M., Mohrluder, J., Ma, P., Stoldt, M., Thielmann, Y., Stangler, T., Hersch, N., Hoffmann, B., Merkel, R., & Willbold, D. (2009) · Autophagy · doi:10.4161/auto.5.5.8494 · Cited by 247 · see citing works

The Scaffold Protein Atg11 Recruits Fission Machinery to Drive Selective Mitochondria Degradation by Autophagy

Mao, K., Wang, K., Liu, X., & Klionsky, D. J. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.024 · Cited by 247 · see citing works

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

Xu, S., Peng, G., Wang, Y., Fang, S., & Karbowski, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-09-0748 · Cited by 243 · see citing works

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

Kim, N. C., Tresse, E., Kolaitis, R., Molliex, A., Thomas, R. E., Alami, N. H., Wang, B., Joshi, A., Smith, R. B., Ritson, G. P., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.029 · Cited by 240 · see citing works

PGC-1α is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle

Leick, L., Wojtaszewski, J. F. P., Johansen, S. T., Kiilerich, K., Comes, G., Hellsten, Y., Hidalgo, J., & Pilegaard, H. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00666.2007 · Cited by 236 · see citing works

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease

Dave, K. D., Silva, S., Sheth, N. P., Ramboz, S., Beck, M. J., Quang, C., Switzer, R. C., Ahmad, S. O., Sunkin, S. M., Walker, D., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.06.009 · Cited by 222 · see citing works

Phosphorylation of Serine 114 on Atg32 mediates mitophagy

Aoki, Y., Kanki, T., Hirota, Y., Kurihara, Y., Saigusa, T., Uchiumi, T., & Kang, D. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-02-0145 · Cited by 222 · see citing works

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

Yamashita, S.-I., Jin, X., Furukawa, K., Hamasaki, M., Nezu, A., Otera, H., Saigusa, T., Yoshimori, T., Sakai, Y., Mihara, K., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201605093 · Cited by 209 · see citing works

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

Rainbolt, T. K., Atanassova, N., Genereux, J. C., & Wiseman, R. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.006 · Cited by 205 · see citing works

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes

Honda, S., Arakawa, S., Nishida, Y., Yamaguchi, H., Ishii, E., & Shimizu, S. (2014) · Nature Communications · doi:10.1038/ncomms5004 · Cited by 203 · see citing works

Tissue- and cell-type–specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model

Hämäläinen, R. H., Manninen, T., Koivumäki, H., Kislin, M., Otonkoski, T., & Suomalainen, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311660110 · Cited by 201 · see citing works

Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization

Zhou, Q., Li, H., Li, H., Nakagawa, A., Lin, J. L. J., Lee, E.-S., Harry, B. L., Skeen-Gaar, R. R., Suehiro, Y., William, D., et al. (2016) · Science · doi:10.1126/science.aaf4777 · Cited by 201 · see citing works

Barriers to Male Transmission of Mitochondrial DNA in Sperm Development

DeLuca, S. Z., & O’Farrell, P. H. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.021 · Cited by 188 · see citing works

Nuclear Respiratory Factor 1 Regulates All Ten Nuclear-encoded Subunits of Cytochrome c Oxidase in Neurons

Dhar, S. S., Ongwijitwat, S., & Wong-Riley, M. T. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707587200 · Cited by 188 · see citing works

MitoTimer: A novel tool for monitoring mitochondrial turnover

Hernandez, G., Thornton, C., Stotland, A., Lui, D., Sin, J., Ramil, J., Magee, N., Andres, A., Quarato, G., Carreira, R. S., et al. (2013) · Autophagy · doi:10.4161/auto.26501 · Cited by 187 · see citing works

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Shiba‐Fukushima, K., Arano, T., Matsumoto, G., Inoshita, T., Yoshida, S., Ishihama, Y., Ryu, K., Nukina, N., Hattori, N., & Imai, Y. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004861 · Cited by 186 · see citing works

Autophagy and ubiquitin–proteasome system contribute to sperm mitophagy after mammalian fertilization

Song, W., Yi, Y., Sutovsky, M., Meyers, S. A., & Šutovský, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605844113 · Cited by 178 · see citing works

Metabolic Labeling Reveals Proteome Dynamics of Mouse Mitochondria

Kim, T., Wang, D., Kim, A. K., Lau, E., Lin, A. J., Liem, D. A., Zhang, J., Zong, C., Lam, M. P. Y., & Ping, P. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.021162 · Cited by 175 · see citing works

Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans

Gitschlag, B. L., Kirby, C. S., Samuels, D. C., Gangula, R., Mallal, S. A., & Patel, M. R. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.008 · Cited by 171 · see citing works

Unique insights into maternal mitochondrial inheritance in mice

Luo, S., Ge, Z., Wang, Z., Jiang, Z., Wang, Z., Ouyang, Y., Hou, Y., Schatten, H., & Sun, Q. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303231110 · Cited by 165 · see citing works

Unrestrained erythroblast development in Nix −/− mice reveals a mechanism for apoptotic modulation of erythropoiesis

Diwan, A., Koesters, A. G., Odley, A. M., Pushkaran, S., Baines, C. P., Spike, B. T., Daria, D., Jegga, A. G., Geiger, H., Aronow, B. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610666104 · Cited by 159 · see citing works

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

Onoue, K., Jofuku, A., Ban-Ishihara, R., Ishihara, T., Maeda, M., Koshiba, T., Itoh, T., Fukuda, M., Otera, H., Oka, T., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.111211 · Cited by 158 · see citing works

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

Hughes, A. L., Hughes, C. E., Henderson, K. A., Yazvenko, N., & Gottschling, D. E. (2016) · eLife · doi:10.7554/elife.13943 · Cited by 149 · see citing works

Paternal Mitochondrial Destruction after Fertilization Is Mediated by a Common Endocytic and Autophagic Pathway in Drosophila

Politi, Y., Gal, L., Kalifa, Y., Ravid, L., Elazar, Z., & Arama, E. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.04.005 · Cited by 146 · see citing works

Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy

Kondo‐Okamoto, N., Noda, N. N., Suzuki, S. W., Nakatogawa, H., Takahashi, I., Matsunami, M., Hashimoto, A., Inagaki, F., Ohsumi, Y., & Okamoto, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299917 · Cited by 146 · see citing works

GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy

Scott, I., Webster, B. R., Chan, C. K., Okonkwo, J. U., Han, K., & Sack, M. N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521641 · Cited by 140 · see citing works

Bit-by-bit autophagic removal of parkin-labelled mitochondria

Yang, J., & Yang, W. Y. (2013) · Nature Communications · doi:10.1038/ncomms3428 · Cited by 140 · see citing works

Autophagy and mitophagy participate in ocular lens organelle degradation

Costello, M. J., Brennan, L., Basu, S., Chauss, D., Mohamed, A., Gilliland, K. O., Johnsen, S., Menko, A. S., & Kantorow, M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.017 · Cited by 138 · see citing works

Phylogenomics of Life-Or-Death Switches in Multicellular Animals: Bcl-2, BH3-Only, and BNip Families of Apoptotic Regulators

Aouacheria, A., Brunet, F., & Gouy, M. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi234 · Cited by 125 · see citing works

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy

Abeliovich, H., Zarei, M., Rigbolt, K. T. G., Youle, R. J., & Dengjel, J. (2013) · Nature Communications · doi:10.1038/ncomms3789 · Cited by 119 · see citing works

The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation

Aerbajinai, W., Giattina, M., Lee, Y. T., Raffeld, M. A., & Miller, J. L. (2003) · Blood · doi:10.1182/blood-2002-11-3324 · Cited by 116 · see citing works

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

Zhang, J., Loyd, M. R., Randall, M. S., Waddell, M. B., Kriwacki, R. W., & Ney, P. A. (2012) · Autophagy · doi:10.4161/auto.20764 · Cited by 114 · see citing works

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Kumar, A., Chaugule, V. K., Condos, T., Barber, K. R., Johnson, C., Toth, R. L., Sundaramoorthy, R., Knebel, A., Shaw, G. S., & Walden, H. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3400 · Cited by 109 · see citing works

Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target gene mRNAs

Ongwijitwat, S., Liang, H., Graboyes, E. M., & Wong‐Riley, M. T. T. (2006) · Gene · doi:10.1016/j.gene.2006.01.009 · Cited by 108 · see citing works

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

Burbulla, L. F., Fitzgerald, J. C., Stegen, K., Westermeier, J., Thost, A.-K., Kato, H., Mokranjac, D., Sauerwald, J., Martins, L. M., Woitalla, D., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.103 · Cited by 97 · see citing works

Atypical mitochondrial inheritance patterns in eukaryotes

Breton, S., & Stewart, D. T. (2015) · Genome · doi:10.1139/gen-2015-0090 · Cited by 96 · see citing works

The effects of hibernation on cone visual cells in the ground squirrel.

Remé, C. E., & Young, R. W. (1977) · PubMed · Cited by 93 · see citing works

Extreme-Depth Re-sequencing of Mitochondrial DNA Finds No Evidence of Paternal Transmission in Humans

Pyle, A., Hudson, G., Wilson, I. J., Coxhead, J., Smertenko, T., Herbert, M., Santibanez-Koref, M., & Chinnery, P. F. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005040 · Cited by 77 · see citing works

Mitochondrial degradation during starvation is selective and temporally distinct from bulk autophagy in yeast

Eiyama, A., Kondo‐Okamoto, N., & Okamoto, K. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.030 · Cited by 68 · see citing works

α-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart

Stotland, A. B., & Gottlieb, R. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.032 · Cited by 63 · see citing works

Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans

Valenci, I., Yonai, L., Bar-Yaacov, D., Mishmar, D., & Ben‐Zvi, A. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.11.001 · Cited by 62 · see citing works

Prion-Like Polymerization in Immunity and InflammationPreprint

Cai, X., Xu, H., & Chen, Z. J. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a023580 · Cited by 62 · see citing works

Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes

Hadjivasiliou, Z., Lane, N. J., Seymour, R. M., et al. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.1920 · Cited by 55 · see citing works

Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism

Song, L., McMackin, M. Z., Nguyen, A., & Cortopassi, G. A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.024 · Cited by 32 · see citing works

Autophagy-dependent and -independent mechanisms of mitochondrial clearance during reticulocyte maturation

Zhang, J., & Ney, P. A. (2009) · Autophagy · doi:10.4161/auto.5.7.9749 · Cited by 27 · see citing works

Bilateral multiple renal oncocytomas and cysts associated with a constitutional translocation (8;9)(q24.1;q34.3) and a rare constitutional VHL missense substitution

Teh, B. T., Blennow, E., Giraud, S., Sahlén, S., Hii, S.-I., Brookwell, R., Brauch, H. B., Nordenskjöld, M., Larsson, C., & Nicol, D. L. (1998) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199803)21:3 · Cited by 25 · see citing works

The cell biology of mitochondrial membrane dynamics

Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550 · see citing works

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476 · see citing works

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

Gómez-Virgilio, L., Silva-Lucero, M.-D.-C., Flores-Morelos, D.-S., Gallardo-Nieto, J., Lopez-Toledo, G., Abarca-Fernandez, A.-M., Zacapala-Gómez, A.-E., Luna-Muñoz, J., Montiel-Sosa, F., Soto-Rojas, L. O., et al. (2022) · Cells · doi:10.3390/cells11152262 · Cited by 431 · see citing works

The cell biology of the retinal pigment epithelium

Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works

Diverse Cellular Roles of Autophagy

Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125300 · Cited by 376 · see citing works

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Vizioli, M. G., Liu, T., Miller, K. N., Robertson, N. A., Gilroy, K., Lagnado, A. B., Perez-Garcia, A., Kiourtis, C., Dasgupta, N., Lei, X., et al. (2020) · Genes &amp; Development · doi:10.1101/gad.331272.119 · Cited by 359 · see citing works

Defective mitophagy in Alzheimer’s disease

Pradeepkiran, J. A., & Reddy, P. H. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101191 · Cited by 367 · see citing works

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila

Cornelissen, T., Vilain, S., Vints, K., Gounko, N., Verstreken, P., & Vandenberghe, W. (2018) · eLife · doi:10.7554/elife.35878 · Cited by 239 · see citing works

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236 · see citing works

Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

Caielli, S., Cardenas, J., de Jesus, A. A., Baisch, J., Walters, L., Blanck, J. P., Balasubramanian, P., Stagnar, C., Ohouo, M., Hong, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.021 · Cited by 228 · see citing works

ESCRT-mediated phagophore sealing during mitophagy

Zhen, Y., Spangenberg, H., Munson, M. J., Brech, A., Schink, K. O., Tan, K.-W., Sørensen, V., Wenzel, E. M., Radulovic, M., Engedal, N., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1639301 · Cited by 209 · see citing works

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery

Picca, A., Guerra, F., Calvani, R., Romano, R., Coelho-Júnior, H. J., Bucci, C., & Marzetti, E. (2021) · Biomolecules · doi:10.3390/biom11101508 · Cited by 189 · see citing works

A gene toolbox for monitoring autophagy transcription

Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death &amp; Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131 · see citing works

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

Schmukler, E., Solomon, S., Simonovitch, S., Goldshmit, Y., Wolfson, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2020) · Cell Death &amp; Disease · doi:10.1038/s41419-020-02776-4 · Cited by 125 · see citing works

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Zaninello, M., Palikaras, K., Naon, D., Iwata, K., Herkenne, S., Quintana-Cabrera, R., Semenzato, M., Grespi, F., Ross-Cisneros, F. N., Carelli, V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17821-1 · Cited by 92 · see citing works

The mitochondrial permeability transition: Nexus of aging, disease and longevity

Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

Peng, W., Minakaki, G., Nguyen, M., & Krainc, D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00742-3 · Cited by 79 · see citing works

Toward understanding genomic instability, mitochondrial dysfunction and aging

Fakouri, N. B., Hou, Y., Demarest, T. G., Christiansen, L. S., Okur, M. N., Mohanty, J. G., Croteau, D. L., & Bohr, V. A. (2019) · The FEBS Journal · doi:10.1111/febs.14663 · Cited by 77 · see citing works

The Role of Mitophagy in Regulating Cell Death

Li, S., Zhang, J., Liu, C., Wang, Q., Yan, J., Hui, L., Jia, Q., Shan, H., Tao, L., & Zhang, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6617256 · Cited by 76 · see citing works

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

Sanchez-Contreras, M., Sweetwyne, M. T., Tsantilas, K. A., Whitson, J. A., Campbell, M. D., Kohrn, B. F., Kim, H. J., Hipp, M. J., Fredrickson, J., Nguyen, M. M., et al. (2023) · eLife · doi:10.7554/elife.83395 · Cited by 71 · see citing works

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Urra, F. A., Muñoz, F., Córdova-Delgado, M., Ramírez, M. P., Peña-Ahumada, B., Rios, M., Cruz, P., Ahumada-Castro, U., Bustos, G., Silva-Pavez, E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31367-9 · Cited by 69 · see citing works

The role of autophagy in brown and beige adipose tissue plasticity

Cairó, M., & Villarroya, J. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00708-1 · Cited by 53 · see citing works

Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease

Lee, S.-E., Kwon, D., Shin, N., Kong, D., Kim, N. G., Kim, H.-Y., Kim, M.-J., Choi, S. W., & Kang, K.-S. (2022) · Cell Death Discovery · doi:10.1038/s41420-021-00796-3 · Cited by 53 · see citing works

Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control

Mukkala, A. N., Jerkic, M., Khan, Z., Szaszi, K., Kapus, A., & Rotstein, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115788 · Cited by 45 · see citing works

Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis

Wang, J., Jia, D., Zhang, Z., & Wang, D. (2025) · Metabolites · doi:10.3390/metabo15010059 · Cited by 23 · see citing works

Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity

Louwagie, E. J., Larsen, T. D., Wachal, A. L., Gandy, T. C. T., Eclov, J. A., Rideout, T. C., Kern, K. A., Cain, J. T., Anderson, R. H., Mdaki, K. S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101746 · Cited by 20 · see citing works

When friendship turns sour: Effective communication between mitochondria and intracellular organelles in parkinson’s disease

Lin, T.-K., Lin, K.-J., Lin, K.-L., Liou, C.-W., Chen, S.-D., Chuang, Y.-C., Wang, P.-W., Chuang, J.-H., & Wang, T.-J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607392 · Cited by 19 · see citing works

Sarcopenia and Ageing

Cheng, K. Y.-K., Bao, Z., Long, Y., Liu, C., Huang, T., Cui, C., Chow, S. K.-H., Wong, R. M. Y., & Cheung, W.-H. (2023) · Subcellular Biochemistry · doi:10.1007/978-3-031-26576-1_6 · Cited by 14 · see citing works

Varespladib attenuates <i>Naja atra</i> -induced acute liver injury via reversing Nrf2 signaling-mediated ferroptosis and mitochondrial dysfunction

Liu, J., Wang, L., Xie, M., Zhao, W., Sun, J., Jin, Y., Liu, M., Zhao, J., Cheng, L., Wen, C., et al. (2025) · Redox Report · doi:10.1080/13510002.2025.2507557 · Cited by 13 · see citing works

Mitophagy Plays an Essential Role in Reducing Mitochondrial Production of Reactive Oxygen Species and Mutation of Mitochondrial DNA by Maintaining Mitochondrial Quantity and Quality in Yeast

Kurihara, Y., Kanki, T., Aoki, Y., Hirota, Y., Saigusa, T., Uchiumi, T., & Kang, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.280156 · Cited by 279 · see citing works

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

Roberts, R. F., Tang, M. Y. H., Fon, E. A., & Durcan, T. M. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.020 · Cited by 120 · see citing works

An unconventional pathway for mitochondrial protein degradation

Yao, Z., & Klionsky, D. J. (2016) · Autophagy · doi:10.1080/15548627.2016.1235127 · Cited by 11 · see citing works

Mitochondria removal by autophagy

Wang, K., & Klionsky, D. J. (2011) · Autophagy · doi:10.4161/auto.7.3.14502 · Cited by 407 · see citing works

ER-mitochondria contacts as sites of mitophagosome formation

Böckler, S., & Westermann, B. (2014) · Autophagy · doi:10.4161/auto.28981 · Cited by 34 · see citing works