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Cited by 513

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

Open access
Martínez-Reyes, Inmaculada, Diebold, Lauren P., Kong, Hyewon, Schieber, Michael, Huang, He, Hensley, Christopher T., Mehta, Manan M., Wang, Tianyuan, Santos, Janine H., Woychik, Richard, Dufour, Eric, Spelbrink, Johannes N., Weinberg, Samuel E., Zhao, Yingming, DeBerardinis, Ralph J., Chandel, Navdeep S.·2016·Molecular Cell
DOI 10.1016/j.molcel.2015.12.002
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Abstract

Mitochondrial metabolism is necessary for the maintenance of oxidative TCA cycle function and mitochondrial membrane potential. Previous attempts to decipher whether mitochondria are necessary for biological outcomes have been hampered by genetic and pharmacologic methods that simultaneously disrupt multiple functions linked to mitochondrial metabolism. Here, we report that inducible depletion of mitochondrial DNA (ρ° cells) diminished respiration, oxidative TCA cycle function and the mitochondrial membrane potential resulting in diminished cell proliferation, hypoxic activation of HIF-1, and specific histone acetylation marks. Genetic reconstitution only of the oxidative TCA cycle function specifically in these inducible ρ° cells restored metabolites resulting in reestablishment of histone acetylation. In contrast, genetic reconstitution of the mitochondrial membrane potential restored ROS, which were necessary for hypoxic activation of HIF-1 and cell proliferation. These results indicate that distinct mitochondrial functions associated with respiration are necessary for cell proliferation, epigenetics, and HIF-1 activation.

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Metadata

Authors
Martínez-Reyes, I., Diebold, L. P., Kong, H., Schieber, M., Huang, H., Hensley, C. T., Mehta, M. M., Wang, T., Santos, J. H., Woychik, R., Dufour, E., Spelbrink, J. N., Weinberg, S. E., Zhao, Y., DeBerardinis, R. J., & Chandel, N. S.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2016-01
Volume
61
Issue
2
Pages
199-209
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2015.12.002
OpenAlex
W2216910489
Cited by
513
References
32
FWCI
13.64
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. https://app.cochat.ai/papers/10.1016/j.molcel.2015.12.002
The paper
Martínez-Reyes, I., Diebold, L. P., Kong, H., Schieber, M., Huang, H., Hensley, C. T., Mehta, M. M., Wang, T., Santos, J. H., Woychik, R., Dufour, E., Spelbrink, J. N., Weinberg, S. E., Zhao, Y., DeBerardinis, R. J., & Chandel, N. S. (2016). TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Molecular Cell. https://doi.org/10.1016/j.molcel.2015.12.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.