Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Regulation of cellular metabolism by protein lysine acetylation

Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science · doi:10.1126/science.1179689 · Cited by 1,910 · see citing works

Cancer's Molecular Sweet Tooth and the Warburg Effect

Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,217 · see citing works

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J.-K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1060 · Cited by 816 · see citing works

Global epidemiology of areca nut usage

Gupta, P., & Warnakulasuriya, S. (2002) · Addiction Biology · doi:10.1080/13556210020091437 · Cited by 644 · see citing works

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

Lv, L., Dong, L., Zhao, D., Lin, R., Chu, Y., Zhang, H., Zha, Z., Liu, Y., Li, Z., Xu, Y., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.025 · Cited by 605 · see citing works

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Lin, R., Tao, R., Gao, X., Li, T., Zhou, X., Guan, K.-L., Xiong, Y., & Lei, Q.-Y. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.002 · Cited by 384 · see citing works

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

CHRISTIE, J. E., Shering, A., Ferguson, J. M., & Glen, A. I. M. (1981) · The British Journal of Psychiatry · doi:10.1192/bjp.138.1.46 · Cited by 360 · see citing works

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

Zhao, D., Zou, S., Liu, Y., Zhou, X., Mo, Y., Wang, P., Xu, Y.-H., Dong, B., Xiong, Y., Lei, Q., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.005 · Cited by 341 · see citing works

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

Hitosugi, T., Fan, J., Chung, T., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R. D., Roesel, J. L., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.015 · Cited by 329 · see citing works

Ketone body production and disposal: Effects of fasting, diabetes, and exercise

BALASSE, E. O., & Féry, F. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050304 · Cited by 312 · see citing works

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

Fan, J., Shan, C., Kang, H.-B., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.026 · Cited by 305 · see citing works

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Lin, R., Elf, S., Shan, C., Kang, H.-B., Ji, Q., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J. H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3255 · Cited by 287 · see citing works

α,β-Unsaturated Ketone Is a Core Moiety of Natural Ligands for Covalent Binding to Peroxisome Proliferator-activated Receptor γ

Shiraki, T., Kamiya, N., Shiki, S., Kodama, T. S., Kakizuka, A., & Jingami, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500901200 · Cited by 218 · see citing works

Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective

Sharan, R. N., Mehrotra, R., Choudhury, Y., & Asotra, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042759 · Cited by 216 · see citing works

The thiolase superfamily: condensing enzymes with diverse reaction specificities

Haapalainen, A. M., Meriläinen, G., & Wierenga, R. K. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.11.011 · Cited by 167 · see citing works

Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential

Chang, M. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1527 · Cited by 167 · see citing works

Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth

Shan, C., Elf, S., Ji, Q., Kang, H., Zhou, L., Hitosugi, T., Jin, L., Lin, R., Zhang, L., Seo, J. H., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.020 · Cited by 142 · see citing works

Post-translational modifications and the Warburg effect

Hitosugi, T., & Chen, J. (2013) · Oncogene · doi:10.1038/onc.2013.406 · Cited by 139 · see citing works

Homodimerization Is Essential for the Receptor for Advanced Glycation End Products (RAGE)-mediated Signal Transduction

Zong, H., Madden, A. F., Ward, M. S., Mooney, M. H., Elliott, C. T., & Stitt, A. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133827 · Cited by 132 · see citing works

Multiple-Dose Arecoline Infusions in Alzheimer's Disease

Tariot, P. N. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340023003 · Cited by 100 · see citing works

Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function,

Haapalainen, A. M., Meriläinen, G., Pirilä, P., Kondo, N., Fukao, T., & Wierenga, R. K. (2007) · Biochemistry · doi:10.1021/bi6026192 · Cited by 100 · see citing works

Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut

Bhide, S. V., Shivapurkar, N. M., Gothoskar, S. V., & Ranadive, K. J. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.286 · Cited by 88 · see citing works

Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression

Saraon, P., Trudel, D., Kron, K. J., Dmitromanolakis, A., Trachtenberg, J., Bapat, B. V., van der Kwast, T., Jarvi, K. A., & Diamandis, E. P. (2013) · The Prostate · doi:10.1002/pros.22758 · Cited by 63 · see citing works

Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation

Cheng, H.-L., Su, S.-J., Huang, L., Hsieh, B.-S., Hu, Y.-C., Hung, T.-C., & Chang, K. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-126 · Cited by 52 · see citing works

Mitochondrial proteomics with si RNA knockdown to reveal ACAT 1 and MDH 2 in the development of doxorubicin‐resistant uterine cancer

Lo, Y., Lin, S., Chang, S., Chan, C., Lyu, K. W., Chang, J., May, E. W. S., Lin, D., Chou, H., & Chan, H. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12388 · Cited by 51 · see citing works

Arecoline tumorigenicity in swiss strain mice on normal and vitamin B deficient diet

Bhide, S. V., Gothoskar, S. V., & Shivapurkar, N. M. (1984) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01032602 · Cited by 24 · see citing works

Cytotoxic Effects Produced by Arecoline Correlated to Epigenetic Regulation in Human K-562 Cells

Lin, P., Chang, W.-H., Chen, Y.-H., Lee, C.-C., Lin, Y., & Chang, J. (2011) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2011.539123 · Cited by 22 · see citing works

Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice

Lin, Y.-M., Kuo, W., Velmurugan, B. K., Hsien, H.-H., Hsieh, Y.-L., Hsu, H.-H., Tu, C., Bau, D., Viswanadha, V. P., & Huang, C. (2015) · Environmental Toxicology · doi:10.1002/tox.22204 · Cited by 20 · see citing works

Cytotoxic and cytostatic effects of arecoline on oral mucosal fibroblasts.

Tsai, C. L., Kuo, M. Y., Hahn, L. J., Kuo, Y.-S., Yang, P. J., & Jeng, J. (1997) · PubMed · Cited by 16 · see citing works

Molecular basis of 3-ketothiolase deficiency.

Fukao, T., Yamaguchi, S., Kano, M., Orii, T., Osumi, T., & Hashimoto, T. (1992) · PubMed · Cited by 3 · see citing works

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Zhang, X., Crowley, V. M., Wucherpfennig, T. G., Dix, M. M., & Cravatt, B. F. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0279-5 · Cited by 487 · see citing works

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Patel, C. H., Leone, R. D., Horton, M. R., & Powell, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0032-5 · Cited by 307 · see citing works

Moonlighting functions of metabolic enzymes and metabolites in cancer

Pan, C., Li, B., & Simon, M. C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.031 · Cited by 194 · see citing works

PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation

An, S. L., Yao, Y., Hu, H., Wu, J., Li, J., Li, L., Wu, J., Sun, M., Deng, Z., Zhang, Y., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05952-4 · Cited by 196 · see citing works

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

Hao, M., Hou, S., Li, W., Li, K., Xue, L., Hu, Q., Zhu, L., Chen, Y., Sun, H., Ju, C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz6667 · Cited by 183 · see citing works

Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis

Gu, L., Zhu, Y., Lin, X., Tan, X., Lu, B., & Li, Y. (2020) · Oncogene · doi:10.1038/s41388-020-1156-0 · Cited by 156 · see citing works

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Prochownik, E. V., & Wang, H. (2021) · Cells · doi:10.3390/cells10040762 · Cited by 145 · see citing works

Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis

Zhu, Y., Gu, L., Lin, X., Liu, C., Lu, B., Cui, K., Zhou, F., Zhao, Q., Prochownik, E. V., Fan, C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.015 · Cited by 135 · see citing works

Lipid metabolism in pancreatic cancer: emerging roles and potential targets

Yin, X., Xu, R., Song, J., Ruze, R., Chen, Y., Wang, C., & Xu, Q. (2022) · 癌症：英文版 · doi:10.1002/cac2.12360 · Cited by 132 · see citing works

Ketone Bodies in the Brain Beyond Fuel Metabolism: From Excitability to Gene Expression and Cell Signaling

García-Rodríguez, D., & Giménez-Cassina, A. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.732120 · Cited by 123 · see citing works

Identification of a four‐gene metabolic signature predicting overall survival for hepatocellular carcinoma

Liu, G., Xie, W., Zhang, C., & Xu, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29081 · Cited by 110 · see citing works

Metabolic recoding of epigenetics in cancer

Wang, Y., & Lei, Q. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0302-3 · Cited by 107 · see citing works

The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target

Goudarzi, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116592 · Cited by 101 · see citing works

Areca catechu —From farm to food and biomedical applications

Salehi, B., Коновалов, Д. А., Fru, P., Kapewangolo, P. T., Peron, G., Mileski, K. S., Cardoso, S. M., Pereira, O. R., Nigam, M., Nicola, S., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6665 · Cited by 87 · see citing works

Emerging mechanisms and promising approaches in pancreatic cancer metabolism

Wu, H., Fu, M., Wu, M., Cao, Z., Zhang, Q., & Liu, Z. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06930-0 · Cited by 87 · see citing works

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Chen, G., Luo, Y., Warncke, K., Sun, Y., Yu, D. S., Fu, H., Behera, M., Ramalingam, S. S., Doetsch, P. W., Duong, D. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11214-9 · Cited by 82 · see citing works

Role of tyrosine phosphorylation in modulating cancer cell metabolism

Taddei, M. L., Pardella, E., Pranzini, E., Raugei, G., & Paoli, P. D. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188442 · Cited by 70 · see citing works

Role of de novo cholesterol synthesis enzymes in cancer

Yang, J., Wang, L., & Jia, R. (2020) · Journal of Cancer · doi:10.7150/jca.38598 · Cited by 63 · see citing works

Acetyl-CoA metabolism as a therapeutic target for cancer

Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54 · see citing works

Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy

Zhang, H., Zhao, W., Li, X., & He, Y. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s315998 · Cited by 49 · see citing works

Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid

Wang, Q., Du, T., Zhang, Z., Zhang, Q., Zhang, J., Li, W., Jiang, J., Chen, X., & Hu, H. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.005 · Cited by 45 · see citing works

Protein Lysine Acetylation in Ovarian Granulosa Cells Affects Metabolic Homeostasis and Clinical Presentations of Women With Polycystic Ovary Syndrome

Min, Z., Long, X., Zhao, H., Zhen, X., Li, R., Li, M., Fan, Y., Yu, Y., Zhao, Y., & Qiao, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.567028 · Cited by 43 · see citing works

ACAT1‐Mediated ME2 Acetylation Drives Chemoresistance in Ovarian Cancer by Linking Glutaminolysis to Lactate Production

Zheng, C., Tan, H., Niu, G., Huang, X., Lu, J., Chen, S., Li, H., Zhu, J., Zhou, Z., Xu, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202416467 · Cited by 38 · see citing works

Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs)

Ózsvári, B., Sotgia, F., Simmons, K. J., Trowbridge, R., Foster, R., & Lisanti, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.21259 · Cited by 37 · see citing works

Targeting ACAT1 in cancer: from threat to treatment

Sun, T., & Xiao, X. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1395192 · Cited by 31 · see citing works

Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

Chen, D., Xia, S., Wang, M., Lin, R., Li, Y., Mao, H. Z., Aguiar, M., Famulare, C. A., Shih, A. H., Brennan, C. W., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1040 · Cited by 31 · see citing works

Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals

Gutierrez-Perez, C., & Cramer, R. A. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00093-4 · Cited by 33 · see citing works

Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

Liang, Y., Tan, Y., Chen, G., Fan, J., & Zhang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910268 · Cited by 28 · see citing works

Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target

Zhang, Y., Wei, W., Fan, J., Jin, C., Lü, L., & Fang, W. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.02986-19 · Cited by 27 · see citing works

Cholesterol Metabolism in Pancreatic Cancer

Rebelo, A., Kleeff, J. H., & Sunami, Y. (2023) · Cancers · doi:10.3390/cancers15215177 · Cited by 26 · see citing works

HADHA overexpression disrupts lipid metabolism and inhibits tumor growth in clear cell renal cell carcinoma

Liu, S., Liu, X., Wu, F., Zhang, X., Zhang, H., Gao, D., Bi, D., Qu, H., Ge, J., Xu, Y., et al. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111558 · Cited by 26 · see citing works

ACAT1 regulates tertiary lymphoid structures and correlates with immunotherapy response in non–small cell lung cancer

Jiao, M., Guo, Y., Zhang, H., Wen, H., Chen, P., Wang, Z., Yu, B., Zhuma, K., Zhang, Y., Qie, J., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci181517 · Cited by 24 · see citing works

Persistent organic pollutants promote aggressiveness in prostate cancer

Buñay, J., Kossaï, M., Damon‐Soubeyrand, C., Haze, A. D., Saru, J., Trousson, A., de Joussineau, C., Bouchareb, E., Kocer, A., Vialat, M., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02788-2 · Cited by 24 · see citing works

ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells

Wang, M., Wang, W., You, S., Hou, Z., Ji, M., Xue, N., Du, T., Chen, X., & Jin, J. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.005 · Cited by 24 · see citing works

Drugging ACAT1 for Cancer Therapy

García‐Bermúdez, J., & Birsoy, K. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.023 · Cited by 24 · see citing works

Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

Chen, D., Xia, S., Zhang, R., Li, Y., Famulare, C. A., Fan, H., Wu, R., Wang, M., Zhu, A. C., Elf, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.06.027 · Cited by 24 · see citing works

Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro

Kohrt, S. E., Awadallah, W. N., Phillips, R. A., Case, T. C., Jin, R., Nanda, J. S., Yu, X., Clark, P. E., Yi, Y., Matusik, R. J., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0244 · Cited by 23 · see citing works

Proteomic Analysis Reveals That an Extract of the Plant Lippia origanoides Suppresses Mitochondrial Metabolism in Triple-Negative Breast Cancer Cells

Raman, V., Aryal, U. K., Hedrick, V., Mohallem, R., Fuentes, J. L., Stashenko, E. E., Levy, M., Levy, M. M., & Camarillo, I. G. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00255 · Cited by 22 · see citing works

Acetylation: a new target for protein degradation in cancer

Crawford, C. E. W., & Burslem, G. M. (2025) · Trends in Cancer · doi:10.1016/j.trecan.2025.01.013 · Cited by 20 · see citing works

System-Wide Profiling by Proteome Integral Solubility Alteration Assay of Drug Residence Times for Target Characterization

Sabatier, P., Beusch, C. M., Meng, Z., & Zubarev, R. A. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03506 · Cited by 22 · see citing works

Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice

Bakhtina, A. A., Pharaoh, G. A., Campbell, M. D., Keller, A., Stuppard, R. S., Marcinek, D. J., & Bruce, J. E. (2023) · Nature Aging · doi:10.1038/s43587-023-00366-5 · Cited by 20 · see citing works

Research Progress of Sirtuin4 in Cancer

Bai, Y., Yang, J., Cui, Y., Yao, Y., Wu, F., Liu, C., Fan, X., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.562950 · Cited by 20 · see citing works

The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

Lin, R., Xia, S., Shan, C., Chen, D., Liu, Y., Gao, X. J., Wang, M., Kang, H., Pan, Y., Liu, S., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.02.010 · Cited by 19 · see citing works

Transcriptomic profiling of peroxisome-related genes reveals a novel prognostic signature in hepatocellular carcinoma

Qiu, L., Zhan, K., Malale, K., Wu, X., & Mei, Z. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.04.010 · Cited by 19 · see citing works

Metabolic classifications of renal cell carcinoma reveal intrinsic connections with clinical and immune characteristics

Li, L., Chao, Z., Waikeong, U., Xiao, J., Ge, Y., Wang, Y., Xiong, Z., Ma, S., Wang, Z., Hu, Z., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03978-y · Cited by 19 · see citing works

Lysine Acetyltransferases (KATs) in Disguise: Diseases Implications

Srivastava, S., Kumar, S., Bhatt, R., Ramachandran, R., Trivedi, A. K., & Kundu, T. K. (2023) · The Journal of Biochemistry · doi:10.1093/jb/mvad022 · Cited by 19 · see citing works

Orchestral role of lipid metabolic reprogramming in T-cell malignancy

Mehta, A., Ratre, Y. K., Soni, V. K., Shukla, D., Sonkar, S. C., Kumar, A., & Vishvakarma, N. K. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1122789 · Cited by 18 · see citing works

Profiling of immune responses by lactate modulation in cervical cancer reveals key features driving clinical outcome

Yang, X., Zhang, W., & Zhu, W. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14896 · Cited by 16 · see citing works

How Alcohol Damages Brain Development in Children

Pop-Jordanova, N. D., & Demerdzieva, A. (2022) · PRILOZI · doi:10.2478/prilozi-2022-0034 · Cited by 15 · see citing works

MiR-21 regulates the ACAT1 gene in MCF-7 cells

Дамирович, Ч. М., Razumova, Y. V., Ovchinnikov, V. Y., & Gulyaeva, L. F. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.010 · Cited by 15 · see citing works

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2

Smolková, K., Špačková, J., Gotvaldová, K., Dvořák, A., Křenková, A., Hubálek, M., Holendová, B., Vı́tek, L., & Ježek, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-65351-z · Cited by 15 · see citing works

Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge

Moore, E. S., Daugherity, E. K., Karambizi, D. I., Cummings, B. P., Behling‐Kelly, E. L., Schaefer, D. M. W., Southard, T. L., McFadden, J. W., & Weiss, R. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005729 · Cited by 13 · see citing works

Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation

Fernandes, M. B., Costa, M., Ribeiro, M. F., Siquenique, S., Santos, S. S., Martins, J., Coelho, A. V., Silva, M. F. B., Rodrigues, C. M. P., & Solá, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00335 · Cited by 13 · see citing works

The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study

Paranagama, M. P., Piyarathne, N. S., Nandasena, T., Jayatilake, S., Navaratne, A. N., Galhena, B. P., Williams, S., Rajapakse, J., & Kita, K. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-03048-6 · Cited by 13 · see citing works

The Effect of Fatty Acids on Ciprofloxacin Cytotoxic Activity in Prostate Cancer Cell Lines—Does Lipid Component Enhance Anticancer Ciprofloxacin Potential?

Chrzanowska, A., Olejarz, W., Kubiak-Tomaszewska, G., Ciechanowicz, A. K., & Struga, M. (2022) · Cancers · doi:10.3390/cancers14020409 · Cited by 13 · see citing works

Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1

Peng, K., Wang, S., Liu, R., Zhou, L., Jeong, G. H., Jeong, I. H., Liu, X., Kiyokawa, H., Xue, B., Zhao, B., et al. (2023) · Biochemistry · doi:10.1021/acs.biochem.2c00624 · Cited by 12 · see citing works

Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway

You, S., Wang, M., Hou, Z., Wang, W., Du, T., Xue, N., Ji, M., & Chen, X. (2023) · Pharmaceuticals · doi:10.3390/ph16060877 · Cited by 12 · see citing works

SIRT5 participates in the suppressive tumor immune microenvironment of EGFR-mutant LUAD by regulating the succinylation of ACAT1

Shouhan, W., Li, Q., & Xiaodan, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39743 · Cited by 12 · see citing works

Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application

Liang, Z., Deng, L., Zhou, X., Zhang, Z., & Zhao, W. (2025) · Biomedicines · doi:10.3390/biomedicines13010210 · Cited by 12 · see citing works

Oxidative Stress and Endoplasmic Reticulum Stress Contributes to Arecoline and Its Secondary Metabolites-Induced Dyskinesia in Zebrafish Embryos

Yan, W., Zhang, T., Li, S., Wang, Y., Zhu, L., Cao, Y., Lai, X., & Huang, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076327 · Cited by 10 · see citing works

Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing

Bisht, V. S., Giri, K., Kumar, D., & Ambatipudi, K. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1992233 · Cited by 8 · see citing works

Prostate Cancer: Emerging Modifiable Risk Factors and Therapeutic Strategies in the Management of Advanced Cancer

Bossio, S., Urlandini, L., Perri, A., Conforti, F., Aversa, A., Agostino, S. D., & Rago, V. (2024) · Life · doi:10.3390/life14091094 · Cited by 10 · see citing works

Advancing rhodium nanoparticle-based photodynamic cancer therapy: quantitative proteomics and in vivo assessment reveal mechanisms targeting tumor metabolism, progression and drug resistance

Machuca, A., Peñalver, G. A., García, R. Á.-F., Martínez‐López, A., Castillo‐Lluva, S., García‐Calvo, E., & Luque-Garcia, J. L. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01631a · Cited by 8 · see citing works

Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity

Tamir, T. Y., Chaudhary, S., Li, A. X., Trojan, S., Flower, C. T., Vo, P., Cui, Y., Davis, J. C., Mukkamala, R. S., Venditti, F. N., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2025.05.007 · Cited by 8 · see citing works

Bacterial polyynes uncovered: a journey through their bioactive properties, biosynthetic mechanisms, and sustainable production strategies

Chin, W.-C., Zhou, Y.-Z., Wang, H.-Y., Feng, Y., Yang, R., Huang, Z.-F., & Yang, Y. (2024) · Natural Product Reports · doi:10.1039/d3np00059a · Cited by 8 · see citing works

Silencing lncRNA‐DARS‐AS1 suppresses nonsmall cell lung cancer progression by stimulating miR‐302a‐3p to inhibit ACAT1 expression

Li, J., Li, Y., Sun, X., Wei, L., Guan, J., Fu, L., Du, J., Zhang, X., Cheng, M., Ma, H., et al. (2024) · Molecular Carcinogenesis · doi:10.1002/mc.23686 · Cited by 8 · see citing works

Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing

Israël, M., Berg, E. P., & Tenenbaum, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041589 · Cited by 8 · see citing works

ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism

You, S., Wang, M., Hou, Z., Wang, W., Zhang, Z., Du, T., Li, S., Liu, Y.-C., Xue, N., Hu, X.-M., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.96651 · Cited by 7 · see citing works

Adipocyte metabolic state regulates glial phagocytic function

Alassaf, M., Madan, A., Ranganathan, S., Marschall, S., Wong, J. J., Goldberg, Z. H., Brent, A. E., & Rajan, A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115704 · Cited by 7 · see citing works

Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells

Zhang, R., Chen, D., Fan, H., Wu, R., Tu, J., Zhang, F. Q., Wang, M., Zheng, H., Qu, C., Elf, S., et al. (2022) · Cell chemical biology · doi:10.1016/j.chembiol.2022.03.010 · Cited by 6 · see citing works

The expression of ACAT1 in oral squamous cell carcinoma and the adjacent pre-tumour tissue

Firouzpour, H., Shokrolahi, S. M., a-Flin, E. B., Derakhshan, S., Shahsavari, Z., Karimi, A., Sadeghi, H. M. M., & Goudarzi, A. (2022) · Biomedicine · doi:10.37796/2211-8039.1363 · Cited by 6 · see citing works

Downregulation of Acat1 by miR-21 may participate in liver fibrosis upon chronic DDT exposure

Дамирович, Ч. М., Yarushkin, A. A., Владимировна, К. Е., Lushnikova, E. L., & Gulyaeva, L. F. (2020) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2020.1777493 · Cited by 6 · see citing works

Prognostic value of a lactate metabolism gene signature in lung adenocarcinoma and its associations with immune checkpoint blockade therapy response

Huang, T., Lian, D., Chen, M., Liu, Y., Zhang, M., Zeng, D., Zhou, S., & Ying, W. (2024) · Medicine · doi:10.1097/md.0000000000039371 · Cited by 5 · see citing works

Cholesterol acyltransferase-1: A novel diagnostic biomarker and potential therapeutic target for cancer

Mao, S., Zhou, W., Cheng, A., Cao, H., & Bei, Y. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106820 · Cited by 5 · see citing works

ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3β/c-Myc signaling pathway

Wang, T., Wang, G., Shan, D., Fang, Y., Zhou, F., Yu, M.-X., Ju, L., Li, G., Xiang, W., Qian, K., et al. (2024) · Journal of Cancer · doi:10.7150/jca.95549 · Cited by 5 · see citing works

From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer

He, W., Li, Y., Liu, S., Chang, Y., Han, S., Han, X., Ma, Z., Amin, H. M., Song, Y.-H., & Zhou, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1449525 · Cited by 4 · see citing works

Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers

Robledo‐Cadena, D. X., Pacheco-Velázquez, S. C., Vargas-Navarro, J. L., Padilla-Flores, J. A., Moreno‐Sánchez, R., & Rodríguez‐Enríquez, S. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575254320231030051124 · Cited by 3 · see citing works

Differential effects of areca nut, tobacco, and lime on oral squamous cell carcinoma progression

Verma, T., Adhikari, S., Kandpal, M., & Jha, H. C. (2024) · Frontiers in Cancer Control and Society · doi:10.3389/fcacs.2024.1414881 · Cited by 3 · see citing works

ACAT1 regulates tertiary lymphoid structures: A target for enhancing immunotherapy in non–small cell lung cancer

O'Keefe, S., & Wang, Q. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191094 · Cited by 3 · see citing works

Seventy five years of research in processing and product development in plantation crops - Coconut, arecanut and cocoa

Hebbar, K. B., Pandiselvam, R., Shameena Beegum, P. P., Ramesh, S. V., Manikantan, M. R., & Mathew, A. C. (2022) · International Journal of Innovative Horticulture · doi:10.5958/2582-2527.2022.00011.2 · Cited by 3 · see citing works

Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis

Yalaza, C., Antmen, Ş. E., Canacankatan, N., Tuncel, F., Aytan, H., & Ertürk, S. E. (2023) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.galenos.2023.05942 · Cited by 3 · see citing works

The effect and mechanism of areca nut in ovarian cancer were investigated based on network pharmacology, molecular docking, and in vitro experiments

Xu, S., Zhu, Q., Zhang, J., Li, X., Liang, M., & Sun, J. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151943 · Cited by 2 · see citing works

ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis

Yan, J., Lin, S., Chen, Z., Zhou, S., Zhao, Y., 王维维, Wang, Z., Feng, Y., & Luo, L. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116626 · Cited by 2 · see citing works

The Association of Ketolytic Enzyme Gene Expression Levels with Mitochondrial Activity and Content in Oral Squamous Cell Carcinoma

Yousefi, M., Karimi, A., & Goudarzi, A. (2022) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2022.23.11.3953 · Cited by 2 · see citing works

The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis

Wu, X., Liu, R., Zhang, Z., Yang, J., Liu, X., Jiang, L., Fang, M., Wang, S., Lai, L., Song, Y., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00113-2 · Cited by 2 · see citing works

ANTICANCER PROPERTY OF AN AYURVEDIC POLYHERBAL PREPARATION CHIEFLY CONTAINING ARECA NUT AND BETEL LEAF

Bhat, J. G., Bhat, M. G., Bhat, S. K., Bhat, S., & Pujari, G. R. (2023) · International Journal of Research in Ayurveda and Pharmacy · doi:10.7897/2277-4343.14015 · Cited by 2 · see citing works

Acetyl-coenzyme A acetyltransferase 1 promotes brown adipogenesis by activating the AMPK-PGC1α signaling pathway

Zhu, K., Ni, L., Han, J., Yan, Z., Zhang, Y., Wang, F., Wang, L., & Yang, X. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159369 · Cited by 3 · see citing works

Cytotoxic, apoptotic, anti-inflammatory and oxidative stress reduction potential of the defatted methanolic extract of the Areca catechu L. (Arecaceae) inflorescence in HepG2 cancer cell lines

Aswany, T., Helen, P. A. M., Ijinu, T., Sasidharan, S., Ramachandran, R., George, V., & Pushpangadan, P. (2023) · Annals of Phytomedicine An International Journal · doi:10.54085/ap.2023.12.2.59 · Cited by 1 · see citing works

Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma

Tuna, M., Liu, W., Amos, C. I., & Mills, G. B. (2019) · Neoplasia · doi:10.1016/j.neo.2019.08.008 · Cited by 2 · see citing works

Mitochondrial cholesterol metabolism related gene model predicts prognosis and treatment response in hepatocellular carcinoma

Guo, X., Wang, F., Li, X., Luo, Q., Liu, B., & Yuan, J. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-1153 · Cited by 1 · see citing works

Cytotoxic and apoptotic activity of Satureja sahendica Bornm essential oil in MDA-MB-231 breast cancer and A549 lung cancer cells: in vitro evidence

Shiralizadeh, M., Shakeri, R., Pouraghajan, K., Safavi, M., & Khorshidi, J. (2025) · 3 Biotech · doi:10.1007/s13205-025-04656-0 · Cited by 1 · see citing works

Magnolia officinalis (L.) Bark Extract Counteracts Oxidative Brain Injury: A Proteomic Investigation into Neuroprotective Mechanisms

Mattioli, L., Stella, R., Peggion, C., Cagnin, S., Pifferi, A., Miraldi, E., Cappellucci, G., Baini, G., Camarda, L., Budriesi, R., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083350 · Cited by 1 · see citing works

Pharmacological and biological activities of areca nut (Areca catechu L.): A systematic review

Sarma, A., Ramesha, N. K., Kumar, M., Udupa, S., Thorat, S. A., Kaniyassery, A., Naik, M. K., Chiang, Y.-C., & Muthusamy, A. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04393-9 · Cited by 1 · see citing works

RND3 Enhances Cardiac Glucose Metabolism Through Inhibiting ACAT1-Dependent PDHA1 Acetylation and Protects Against Ischemia-Reperfusion Injury

Xiong, Z., Li, Y., Zhang, Y., Ma, Z., Qi, M., Zhang, H. R., Zhang, X., Jiang, M., Liu, J., Gao, E., et al. (2026) · Circulation · doi:10.1161/circulationaha.125.075591 · Cited by 1 · see citing works

Interspecies comparison on the O-methylation metabolism of LJR003, a novel immunomodulator targeting acetyl-CoA acetyltransferase 1

Chang, Y., Zhang, W., Liu, X., Luo, L., Chen, J., Zhao, Y., Chen, X., Ji, M., & Li, S. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116894 · Cited by 1 · see citing works

A better angel of our nature: H anna M ichel “ J ean” K houry, M D ( A pril 24, 1967– M ay 22, 2017)

Khuri, F. R. (2017) · Cancer · doi:10.1002/cncr.30847

Multi-omics approach to identify bacterial polyynes and unveil their antifungal mechanism against Candida albicansPreprint

Lin, C.-C., Hoo, S. Y., Lin, C., Huang, K.-F., Ho, Y.-N., Sun, C.-H., Lee, H., Chen, P.-Y., Shu, L., Wang, B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.30.437786

Faculty Opinions recommendation of Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16.

Chiang, C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735998607.793561779

Data from Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro

Kohrt, S. E., Awadallah, W. N., Phillips, R. A., Case, T. C., Jin, R., Nanda, J. S., Yu, X., Clark, P. E., Yi, Y., Matusik, R. J., et al. (2023) · doi:10.1158/1535-7163.c.6543087

Unraveling the Cancer Metabolism: Fasting Reset, Ketogenic Diet and Therapeutic Strategies

Tenenbaum, G., Berg, E. P., & Israël, M. (2023) · Journal of Cancer Research Reviews & Reports · doi:10.47363/jcrr/2023(5)176

The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target

Goudarzi, A. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116592 · Cited by 101 · see citing works

Drugging ACAT1 for Cancer Therapy

García‐Bermúdez, J., & Birsoy, K. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.023 · Cited by 24 · see citing works

Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect

Fan, J., Gu, T., Boggon, T. J., Kang, S., & Chen, J. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-3362

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

Fan, J., Shan, C., Kang, H.-B., Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.026 · Cited by 305 · see citing works

Cancer Metabolism: Fasting Reset, the Keto-Paradox and Drugs for Undoing

Israël, M., Berg, E. P., & Tenenbaum, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041589 · Cited by 8 · see citing works