Arginine Methylation: The Coming of Age

Protein Arginine Methylation in Mammals: Who, What, and Why

Bedford, M. T., & Clarke, S. G. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.013 · Cited by 1,810 · see citing works

Protein arginine methyltransferases and cancer

Yang, Y., & Bedford, M. T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3409 · Cited by 1,104 · see citing works

Defining the RGG/RG Motif

Thandapani, P., O’Connor, T. R., Bailey, T. L., & Richard, S. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.021 · Cited by 690 · see citing works

<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Kryukov, G. V., Wilson, F. H., Ruth, J. R., Paulk, J., Tsherniak, A., Marlow, S. E., Vazquez, F., Weir, B. A., Fitzgerald, M. E., Tanaka, M., et al. (2016) · Science · doi:10.1126/science.aad5214 · Cited by 688 · see citing works

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Mavrakis, K. J., McDonald, E. R., Schlabach, M. R., Billy, E., Hoffman, G. R., deWeck, A., Ruddy, D. A., Venkatesan, K., Yu, J., McAllister, G., et al. (2016) · Science · doi:10.1126/science.aad5944 · Cited by 607 · see citing works

Histone arginine methylation regulates pluripotency in the early mouse embryo

Torres‐Padilla, M., Parfitt, D.-E., Kouzarides, T., & Zernicka‐Goetz, M. (2007) · Nature · doi:10.1038/nature05458 · Cited by 592 · see citing works

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Chan-Penebre, E., Kuplast, K. G., Majer, C. R., Boriack-Sjodin, P. A., Wigle, T. J., Johnston, L. D., Rioux, N., Munchhof, M. J., Jin, L., Jacques, S. L., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1810 · Cited by 569 · see citing works

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q., Rank, G., Tan, Y., Li, H., Moritz, R. L., Simpson, R. J., Cerruti, L., Curtis, D. J., Patel, D. J., Allis, C. D., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1568 · Cited by 539 · see citing works

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

Guccione, E., Bassi, C., Casadio, F., Martinato, F., Cesaroni, M., Schuchlautz, H., Lüscher, B., & Amati, B. B. (2007) · Nature · doi:10.1038/nature06166 · Cited by 495 · see citing works

MTAP deletions in cancer create vulnerability to targeting of the MAT2A/PRMT5/RIOK1 axis

Marjon, K., Cameron, M. J., Quang, P., Clasquin, M. F., Mandley, E., Kunii, K., McVay, M., Choe, S., Kernytsky, A., Gross, S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.043 · Cited by 485 · see citing works

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

Goolam, M., Scialdone, A., Graham, S. J. L., Macaulay, I. C., Jedrusik, A., Hupalowska, A., Voet, T., Marioni, J. C., & Zernicka-Goetz, M. (2016) · Cell · doi:10.1016/j.cell.2016.01.047 · Cited by 484 · see citing works

Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, K. K., & Li, S. S.-C. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3915 · Cited by 479 · see citing works

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

Webby, C. J., Wolf, A., Gromak, N., Dreger, M., Kramer, H., Kessler, B. M., Nielsen, M. L., Schmitz, C., Butler, D. S., Yates, J. R., et al. (2009) · Science · doi:10.1126/science.1175865 · Cited by 423 · see citing works

The Arginine Methyltransferase CARM1 Regulates the Coupling of Transcription and mRNA Processing

Cheng, D., Côté, J., Shaaban, S. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.019 · Cited by 395 · see citing works

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

Koh, C. M., Bezzi, M., Low, D. H. P., Ang, W. X., Teo, S. X., Gay, F. P. H., Al‐Haddawi, M., Tan, S., Osato, M., Sabò, A., et al. (2015) · Nature · doi:10.1038/nature14351 · Cited by 379 · see citing works

Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln

Meister, G., Eggert, C., Bühler, D., Brahms, H., Kambach, C., & Fischer, U. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00592-9 · Cited by 373 · see citing works

Crystal structure of the human PRMT5:MEP50 complex

Antonysamy, S., Bonday, Z., Campbell, R. M., Doyle, B. L., Druzina, Z., Gheyi, T., Han, B., Jungheim, L. N., Qian, Y., Rauch, C. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209814109 · Cited by 373 · see citing works

Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides

Zhang, X., & Cheng, X. (2003) · Structure · doi:10.1016/s0969-2126(03)00071-6 · Cited by 361 · see citing works

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotencyPreprint

Tee, W., Pardo, M., Theunissen, T. W., Yu, L., Choudhary, J. S., Hájková, P., & Surani, M. A. (2010) · Genes & Development · doi:10.1101/gad.606110 · Cited by 360 · see citing works

Arginine N -Methyltransferase 1 Is Required for Early Postimplantation Mouse Development, but Cells Deficient in the Enzyme Are Viable

Pawlak, M. R., Scherer, C., Chen, J., Roshon, M. J., & Ruley, H. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4859-4869.2000 · Cited by 355 · see citing works

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Migliori, V., Müller, J., Phalke, S., Low, D. H. P., Bezzi, M., Mok, W. C., Sahu, S. K., Gunaratne, J., Capasso, P., Bassi, C., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2209 · Cited by 351 · see citing works

Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation

Fuhrmann, J., Clancy, K. W., & Thompson, P. R. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00003 · Cited by 325 · see citing works

Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells

Buch-Larsen, S. C., Sylvestersen, K. B., Mund, A., Lyon, D. B., Mullari, M., Madsen, M. V., Daniel, J. A., Jensen, L. J., & Nielsen, M. L. (2016) · Science Signaling · doi:10.1126/scisignal.aaf7329 · Cited by 318 · see citing works

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machineryPreprint

Bezzi, M., Teo, S. X., Müller, J., Mok, W. C., Sahu, S. K., Vardy, L. A., Bonday, Z., & Guccione, E. (2013) · Genes & Development · doi:10.1101/gad.219899.113 · Cited by 300 · see citing works

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Eram, M. S., Shen, Y., Szewczyk, M. M., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00839 · Cited by 290 · see citing works

CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis

Wang, L., Zhao, Z., Meyer, M. B., Saha, S. A., Yu, M., Guo, A., Wisinski, K. B., Huang, W., Cai, W., Pike, J. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2013.12.007 · Cited by 267 · see citing works

Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.

Afar, D., Vivanco, I., Hubert, R., Kuo, J., Chen, E., Saffran, D. C., Raitano, A. B., & Jakobovits, A. (2001) · PubMed · Cited by 266 · see citing works

PRMT8, a New Membrane-bound Tissue-specific Member of the Protein Arginine Methyltransferase Family

Lee, J. H., Sayegh, J., Daniel, J. A., Clarke, S. G., & Bedford, M. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506944200 · Cited by 262 · see citing works

Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation

Yang, Y., McBride, K. M., Hensley, S. C., Lu, Y., Chedin, F. L., & Bedford, M. T. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.011 · Cited by 253 · see citing works

PRMT9 is a Type II methyltransferase that methylates the splicing factor SAP145

Yang, Y., Hadjikyriacou, A., Xia, Z., Gayatri, S., Kim, D., Zurita‐Lopez, C. I., Kelly, R. L., Guo, A., Li, W., Clarke, S. G., et al. (2015) · Nature Communications · doi:10.1038/ncomms7428 · Cited by 240 · see citing works

SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination

Zhao, D. Y., Gish, G. D., Braunschweig, U., Li, Y., Ni, Z., Schmitges, F. W., Zhong, G., Liu, K., Li, W., Moffat, J., et al. (2015) · Nature · doi:10.1038/nature16469 · Cited by 238 · see citing works

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Walport, L. J., Hopkinson, R. J., Chowdhury, R., Schiller, R., Ge, W., Kawamura, A., & Schofield, C. J. (2016) · Nature Communications · doi:10.1038/ncomms11974 · Cited by 236 · see citing works

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs

Dhar, S., Vemulapalli, V., Patananan, A. N., et al. (2013) · Scientific Reports · doi:10.1038/srep01311 · Cited by 229 · see citing works

Arginine methyltransferase CARM1 is a promoter‐specific regulator of NF‐κB‐dependent gene expression

Covic, M., Hassa, P. O., Saccani, S., Buerki, C., Meier, N. I., Lombardi, C., Imhof, R., Bedford, M. T., Natoli, G., & Hottiger, M. O. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600500 · Cited by 226 · see citing works

Carm1 Regulates Pax7 Transcriptional Activity through MLL1/2 Recruitment during Asymmetric Satellite Stem Cell Divisions

Kawabe, Y.-I., Wang, Y. X., McKinnell, I. W., Bedford, M. T., & Rudnicki, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.07.001 · Cited by 220 · see citing works

Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations

Tradewell, M. L., Yu, Z., Tibshirani, M., Boulanger, M., Durham, H. D., & Richard, S. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr448 · Cited by 213 · see citing works

A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation

Yu, Z., Chen, T., Hébert, J., Li, E., & Richard, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00042-09 · Cited by 209 · see citing works

The Testis-Specific Factor CTCFL Cooperates with the Protein Methyltransferase PRMT7 in H19 Imprinting Control Region Methylation

Jelinic, P., Stehle, J., & Shaw, P. H. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040355 · Cited by 206 · see citing works

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

Tripsianes, K., Madl, T., Machyna, M., Fessas, D., Englbrecht, C., Fischer, U., Neugebauer, K. M., & Sattler, M. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2185 · Cited by 203 · see citing works

Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression

Boulanger, M., Liang, C., Russell, R. S., Lin, R., Bedford, M. T., Wainberg, M. A., & Richard, S. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.124-131.2005 · Cited by 196 · see citing works

Protein arginine methylation of non-histone proteins and its role in diseases

Han, W., Mundade, R., Lange, K., & Lu, T. (2013) · Cell Cycle · doi:10.4161/cc.27353 · Cited by 192 · see citing works

Trans -tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4Preprint

Dhar, S. S., Lee, S.-H., Kan, P., Voigt, P., Ma, L., Shi, X., Reinberg, D., & Lee, M. G. (2012) · Genes & Development · doi:10.1101/gad.203356.112 · Cited by 190 · see citing works

Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization

Goulet, I., Gauvin, G., Boisvenue, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704349200 · Cited by 189 · see citing works

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

Chen, H., Lorton, B. M., Gupta, V., & Shechter, D. (2016) · Oncogene · doi:10.1038/onc.2016.205 · Cited by 184 · see citing works

Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions

Feng, Y., Maity, R., Whitelegge, J. P., Hadjikyriacou, A., Li, Z., Zurita‐Lopez, C. I., Al‐Hadid, Q., Clark, A. T., Bedford, M. T., Masson, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.525345 · Cited by 181 · see citing works

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

Yan, F., Alinari, L., Lustberg, M. E., Katherine Martin, L., Cordero-Nieves, H. M., Banasavadi-Siddegowda, Y., Virk, S., Barnholtz-Sloan, J., Bell, E. H., Wojton, J., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-0884 · Cited by 180 · see citing works

Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia

Cheung, N., Fung, T. K., Zeisig, B. B., Holmes, K. B., Rane, J. K., Mowen, K. A., Finn, M. G., Lenhard, B., Chan, L. C., & So, C. W. E. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.007 · Cited by 173 · see citing works

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

Tarighat, S. S., Santhanam, R., Frankhouser, D., Radomska, H. S., Lai, H., Anghelina, M., Wang, H., Huang, X., Alinari, L., Walker, A., et al. (2016) · Leukemia · doi:10.1038/leu.2015.308 · Cited by 169 · see citing works

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

Deng, X., Shao, G. Q., Zhang, H.-T., Li, C., Zhang, D., Cheng, L., Elzey, B. D., Пили, Р., Ratliff, T. L., Huang, J., et al. (2016) · Oncogene · doi:10.1038/onc.2016.287 · Cited by 169 · see citing works

Readers of histone methylarginine marks

Gayatri, S., & Bedford, M. T. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.02.015 · Cited by 168 · see citing works

β-Catenin Primes Organizer Gene Expression by Recruiting a Histone H3 Arginine 8 Methyltransferase, Prmt2

Blythe, S. A., Cha, S., Tadjuidje, E., Heasman, J., & Klein, P. S. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.007 · Cited by 165 · see citing works

RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity

Guderian, G., Peter, C., Wiesner, J., Sickmann, A., Schulze‐Osthoff, K., Fischer, U., & Grimmler, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148486 · Cited by 163 · see citing works

MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

Bian, S., Hong, J., Li, Q., Schebelle, L., Pollock, A., Knauss, J. L., Garg, V., & Sun, T. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.037 · Cited by 161 · see citing works

Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

Liu, F., Cheng, G., Hamard, P.-J., Greenblatt, S. M., Wang, L., Man, N., Perna, F., Xu, H., Tadi, M., Luciani, L., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81749 · Cited by 155 · see citing works

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Liao, H.-W., Hsu, J.-M., Xia, W., Wang, H.-L., Wang, Y.-N., Chang, W.-C., Arold, S. T., Chou, C.-K., Tsou, P.-H., Yamaguchi, H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci82826 · Cited by 155 · see citing works

H3R42me2a is a histone modification with positive transcriptional effects

Casadio, F., Lu, X., Pollock, S. B., LeRoy, G., Garcia, B. A., Muir, T. W., Roeder, R. G., & Allis, C. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312925110 · Cited by 154 · see citing works

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

Hu, D., Gur, M., Zhou, Z., Gamper, A., Hung, M.-C., Fujita, N., Lan, L., Bahar, I., & Wan, Y. (2015) · Nature Communications · doi:10.1038/ncomms9419 · Cited by 154 · see citing works

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families

study, T. D., Akawi, N. A., McRae, J. F., Ansari, M., Balasubramanian, M., Blyth, M., Brady, A. F., Clayton, S., Cole, T. R. P., Deshpande, C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3410 · Cited by 153 · see citing works

PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer

Yao, R., Jiang, H., Ma, Y., Wang, L., Wang, L., Du, J., Hou, P., Gao, Y., Zhao, L., Wang, G., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0800 · Cited by 151 · see citing works

PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Kim, S., Günesdogan, U., Żylicz, J. J., Hackett, J. A., Cougot, D., Bao, S., Lee, C. Y., Dietmann, S., Allen, G. E., Sengupta, R., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.003 · Cited by 151 · see citing works

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

Alinari, L., Mahasenan, K. V., Yan, F., et al. (2015) · Blood · doi:10.1182/blood-2014-12-619783 · Cited by 148 · see citing works

PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer

Avasarala, S., Scoyk, M. M. V., Rathinam, M. K. K., Zerayesus, S., Zhao, X., Zhang, W., Pergande, M. R., Borgia, J. A., DeGregori, J. V., Port, J. D., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.636050 · Cited by 144 · see citing works

Ribosomal Protein rpS2 Is Hypomethylated in PRMT3-deficient Mice

Swiercz, R., Cheng, D., Kim, D., & Bedford, M. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609778200 · Cited by 143 · see citing works

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers

Li, Y., Chitnis, N., Nakagawa, H., Kita, Y., Natsugoe, S., Yang, Y., Li, Z., Wasik, M., Klein-Szanto, A. J. P., Rustgi, A. K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0625 · Cited by 143 · see citing works

A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

Kanıskan, H. Ü., Szewczyk, M. M., Yu, Z., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201412154 · Cited by 140 · see citing works

PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells

Banasavadi‐Siddegowda, Y., Russell, L., Frair, E. C., Karkhanis, V. A., Relation, T., Yoo, J. Y., Zhang, J., Sif, S., Imitola, J., Baiocchi, R. A., et al. (2016) · Oncogene · doi:10.1038/onc.2016.199 · Cited by 135 · see citing works

Molecular basis underlying histone H3 lysine–arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1Preprint

Su, X., Zhu, G., Ding, X., Lee, S. Y., Dou, Y., Zhu, B., Wu, W., & Li, H. (2014) · Genes & Development · doi:10.1101/gad.233239.113 · Cited by 133 · see citing works

Prmt5 is a regulator of muscle stem cell expansion in adult mice

Zhang, T., Günther, S., Looso, M., Kuenne, C. T., Krüger, M., Kim, J., Zhou, Y., & Braun, T. W. (2015) · Nature Communications · doi:10.1038/ncomms8140 · Cited by 131 · see citing works

Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene, POLD1

Karkhanis, V. A., Wang, L., Tae, S., Hu, Y., Imbalzano, A. N., & Sif, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.378281 · Cited by 131 · see citing works

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt

Sakamaki, J.-I., Daitoku, H., Ueno, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015328108 · Cited by 127 · see citing works

PRMT3 Is a Distinct Member of the Protein Arginine N-Methyltransferase Family

Frankel, A., & Clarke, S. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006445200 · Cited by 125 · see citing works

DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo

Singh, V., Miranda, T. B., Jiang, W., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208057 · Cited by 122 · see citing works

The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1

Gao, Y., Zhao, Y., Zhang, J., Yang, L., Liu, X., Geng, P., Huang, B., Zhang, Y., & Lü, J. (2016) · Scientific Reports · doi:10.1038/srep19874 · Cited by 122 · see citing works

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor

Neault, M., Mallette, F. A., Vogel, G., Michaud‐Levesque, J., & Richard, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks764 · Cited by 120 · see citing works

CARM1 is Required in Embryonic Stem Cells to Maintain Pluripotency and Resist Differentiation

Wu, Q., Bruce, A. W., Jędrusik, A., Ellis, P. D., Andrews, R., Langford, C. F., Glover, D. M., & Zernicka‐Goetz, M. (2009) · Stem Cells · doi:10.1002/stem.131 · Cited by 117 · see citing works

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

Thandapani, P., Song, J., Gandin, V., Cai, Y., Rouleau, S. G., Garant, J., Boisvert, F., Yu, Z., Perreault, J., Topisirović, I., et al. (2015) · eLife · doi:10.7554/elife.06234 · Cited by 117 · see citing works

PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex

Vu, L., Perna, F., Wang, L., Voza, F. A., Figueroa, M. E., Tempst, P., Erdjument‐Bromage, H., Gao, R., Chen, S., Paietta, E. M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.025 · Cited by 113 · see citing works

Distinct Protein Arginine Methyltransferases Promote ATP-Dependent Chromatin Remodeling Function at Different Stages of Skeletal Muscle Differentiation

Dacwag, C. S., Bedford, M. T., Sif, S., & Imbalzano, A. N. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00742-08 · Cited by 110 · see citing works

Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

Scaramuzzino, C., Casci, I., Parodi, S., Lievens, P., Polanco, M. J., Milioto, C., Chivet, M., Monaghan, J., Mishra, A., Badders, N. M., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.031 · Cited by 107 · see citing works

The Role of Protein Arginine Methyltransferases in Inflammatory Responses

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Methylation of H2AR29 is a novel repressive PRMT6 target

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Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro

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Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis

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Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2

Hadjikyriacou, A., Yang, Y., Espejo, A. B., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.659433 · Cited by 102 · see citing works

Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity

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Automethylation of CARM1 allows coupling of transcription and mRNA splicing

Kuhn, P., Chumanov, R. S., Wang, Y., Ge, Y., Burgess, R. R., & Xu, W. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1246 · Cited by 97 · see citing works

Transcription Factor Positive Regulatory Domain 4 (PRDM4) Recruits Protein Arginine Methyltransferase 5 (PRMT5) to Mediate Histone Arginine Methylation and Control Neural Stem Cell Proliferation and Differentiation

Chittka, A., Nitarska, J., Grazini, U., & Richardson, W. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392746 · Cited by 97 · see citing works

PRMT7 Preserves Satellite Cell Regenerative Capacity

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Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression

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Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

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Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response

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Type II Arginine Methyltransferase PRMT5 Regulates Gene Expression of Inhibitors of Differentiation/DNA Binding Id2 and Id4 during Glial Cell Differentiation

Huang, J., Vogel, G., Yu, Z., Almazán, G., & Richard, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277046 · Cited by 88 · see citing works

Increased Protein Arginine Methylation in Chronic Hypoxia

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Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation

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Enzymatic Activity Is Required for the in Vivo Functions of CARM1

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PRMT5 modulates the metabolic response to fasting signals

Tsai, W., Niessen, S., Goebel, N., Yates, J. R., Guccione, E., & Montminy, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304602110 · Cited by 81 · see citing works

The role of arginine methylation in the DNA damage response

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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Wang, L., Zeng, H., Wang, Q., Zhao, Z., Boyer, T., Bian, X., & Xu, W. (2015) · Science Advances · doi:10.1126/sciadv.1500463 · Cited by 80 · see citing works

CARM1 and PRMT1 are dysregulated in lung cancer without hierarchical features

Akoum, R. E., Gauchotte, G., Oussalah, A., Wissler, M.-P., Clément-Duchêne, C., Vignaud, J.-M., Guéant, J., & Namour, F. (2013) · Biochimie · doi:10.1016/j.biochi.2013.10.021 · Cited by 78 · see citing works

ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor

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Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate

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Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy

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PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

Ratovitski, T., Arbez, N., Stewart, J. C., Chighladze, E., & Ross, C. A. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1033595 · Cited by 74 · see citing works

The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis

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Severe Hypomyelination and Developmental Defects Are Caused in Mice Lacking Protein Arginine Methyltransferase 1 (PRMT1) in the Central Nervous System

Hashimoto, M., Murata, K., Ishida, J., Kanou, A., Kasuya, Y., & Fukamizu, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.684514 · Cited by 73 · see citing works

Histone arginine methylation in cocaine action in the nucleus accumbens

Damez-Werno, D. M., Sun, H., Scobie, K. N., Shao, N., Rabkin, J., Dias, C., Calipari, E. S., Maze, I. S., Peña, C. J., Walker, D. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605045113 · Cited by 71 · see citing works

A Germ Cell-specific Gene, Prmt5, Works in Somatic Cell Reprogramming

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miR-503 suppresses metastasis of hepatocellular carcinoma cell by targeting PRMT1

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A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator

Lorenzo, A. D., Yang, Y., Macaluso, M. D., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku530 · Cited by 67 · see citing works

Arginine methylation of the B cell antigen receptor promotes differentiation

Infantino, S., Benz, B., Waldmann, T., Jung, M., Schneider, R., & Reth, M. G. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091303 · Cited by 67 · see citing works

Methods and tips for the purification of human histone methyltransferases

Nishioka, K. (2003) · Methods · doi:10.1016/s1046-2023(03)00087-2 · Cited by 65 · see citing works

PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination

Kim, J., Park, K.-E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500615 · Cited by 65 · see citing works

Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription

Ying, Z., Mei, M., Zhang, P., Liu, C., He, H., Gao, F., & Bao, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500224 · Cited by 63 · see citing works

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity

Singhroy, D. N., Mesplède, T., Sabbah, A., Quashie, P., Falgueyret, J., & Wainberg, M. (2013) · Retrovirology · doi:10.1186/1742-4690-10-73 · Cited by 62 · see citing works

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

de Freitas, R. F., Eram, M. S., Smil, D. V., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00668 · Cited by 62 · see citing works

CARM1 Mediates Modulation of Sox2

Zhao, H., Zhang, Y., Zhang, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027026 · Cited by 60 · see citing works

Arginine methyltransferases in normal and malignant hematopoiesis

Greenblatt, S. M., Liu, F., & Nimer, S. D. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.03.009 · Cited by 59 · see citing works

PRMT1 and PRMT8 Regulate Retinoic Acid-Dependent Neuronal Differentiation with Implications to Neuropathology

Simándi, Z., Czipa, E., Horváth, A., Kőszeghy, Á., Bordás, C., Póliska, S., Juhász, I., Imre, L., Szabó, G., Dezsö, B., et al. (2014) · Stem Cells · doi:10.1002/stem.1894 · Cited by 57 · see citing works

Loss of CARM1 is linked to reduced HuR function in replicative senescence

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A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

Debler, E., Jain, K., Warmack, R. A., Feng, Y., Clarke, S. G., Blobel, G., & Stavropoulos, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525783113 · Cited by 54 · see citing works

Redox Control of Protein Arginine Methyltransferase 1 (PRMT1) Activity

Morales, Y., Nitzel, D. V., Price, O. M., Gui, S., Li, J., Qu, J., & Hevel, J. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.651380 · Cited by 53 · see citing works

Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

Park, J. H., Szemes, M., Vieira, G. C., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.10.015 · Cited by 53 · see citing works

Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures

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CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells

Wang, S.-C., Dowhan, D. H., Eriksson, N. A., & Muscat, G. E. O. (2012) · Biochemical Journal · doi:10.1042/bj20112033 · Cited by 51 · see citing works

Protein Arginine Methyltransferase 6 Regulates Embryonic Stem Cell Identity

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PRMT3 Regulates Hepatic Lipogenesis Through Direct Interaction With LXRα

Kim, D., Park, M.-J., Lim, S.-K., Park, J., Yoon, K. C., Han, H. J., Gustafsson, J.-Α., Lim, J. H., & Park, S.-H. (2014) · Diabetes · doi:10.2337/db13-1394 · Cited by 49 · see citing works

MicroRNA-181 Regulates CARM1 and Histone Aginine Methylation to Promote Differentiation of Human Embryonic Stem Cells

Xu, Z., Jiang, J., Xu, C., Wang, Y., Sun, L., Guo, X., & Liu, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053146 · Cited by 47 · see citing works

The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice

Li, Z., Yu, J., Hosohama, L., Nee, K., Gkountela, S., Chaudhari, S., Cass, A. A., Xiao, X. G., & Clark, A. T. (2014) · The EMBO Journal · doi:10.15252/embj.201489319 · Cited by 47 · see citing works

The protein arginine methyltransferase PRMT 5 regulates Aβ‐induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease

Quan, X., Yue, W., Luo, Y., Cao, J., Wang, H., Wang, Y., & Lu, Z. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13191 · Cited by 46 · see citing works

Proteomic Analysis of Mouse Oocytes Identifies PRMT7 as a Reprogramming Factor that Replaces SOX2 in the Induction of Pluripotent Stem Cells

Wang, B., Pfeiffer, M. J., Drexler, H. C. A., Fuellen, G., & Boiani, M. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b01083 · Cited by 43 · see citing works

PRMT5 is Required for Human Embryonic Stem Cell Proliferation But Not Pluripotency

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LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2

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Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion

Wang, M., Fuhrmann, J., & Thompson, P. R. (2014) · Biochemistry · doi:10.1021/bi501279g · Cited by 38 · see citing works

Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine

Li, Y., Zhu, R., Wang, W., Fu, D., Hou, J., Ji, S., Chen, B., Hu, Z., Shao, X., Yu, X.-R., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0246-15.2015 · Cited by 37 · see citing works

A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy

Sanchez, G., Bondy‐Chorney, E., Laframboise, J., Paris, G., Didillon, A., Jasmin, B. J., & Côté, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1334 · Cited by 37 · see citing works

Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity

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Protein-arginine Methyltransferase 1 (PRMT1) Methylates Ash2L, a Shared Component of Mammalian Histone H3K4 Methyltransferase Complexes

Napierala, J. S., Zurita‐Lopez, C. I., Clarke, S. G., Bedford, M. T., & Dent, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202416 · Cited by 35 · see citing works

PRMT3 is essential for dendritic spine maturation in rat hippocampal neurons

Miyata, S., Mori, Y., & Tohyama, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.033 · Cited by 35 · see citing works

Characterization of prmt7α and β isozymes from Chinese hamster cells sensitive and resistant to topoisomerase II inhibitors

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Coactivator-associated arginine methyltransferase 1 targeted by miR-15a regulates inflammation in acute coronary syndrome

Liu, X., Wang, L., Li, H., Lu, X., Hu, Y., Yang, X., Huang, C. Y., & Gu, D. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.01.039 · Cited by 32 · see citing works

Cross-talk between Arg methylation and Ser phosphorylation modulates apoptosis signal–regulating kinase 1 activation in endothelial cells

Chen, M., Qu, X., Zhang, Z.-Q., Wu, H., Qin, X., Li, F., Liu, Z., Tian, L., Miao, J., & Shu, W. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0738 · Cited by 32 · see citing works

Serine phosphorylation and arginine methylation at the crossroads to neurodegeneration

Basso, M., & Pennuto, M. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.05.003 · Cited by 31 · see citing works

PRMT 5 enhances generation of induced pluripotent stem cells from dairy goat embryonic fibroblasts via down‐regulation of p53

Chu, Z., Niu, B., Zhu, H., He, X., Bai, C., Li, G., & Hua, J. (2014) · Cell Proliferation · doi:10.1111/cpr.12150 · Cited by 31 · see citing works

A Remodeled Protein Arginine Methyltransferase 1 (PRMT1) Generates Symmetric Dimethylarginine

Gui, S., Gathiaka, S. M., Li, J., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.535278 · Cited by 31 · see citing works

CARM1 regulates astroglial lineage through transcriptional regulation of Nanog and posttranscriptional regulation by miR92a

Selvi, B. R., Swaminathan, A., Neelathi, U. M., et al. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-01-0019 · Cited by 30 · see citing works

O-GlcNAcylation of co-activator-associated arginine methyltransferase 1 regulates its protein substrate specificity

Charoensuksai, P., Kuhn, P., Wang, L., Sherer, N. M., & Xu, W. (2015) · Biochemical Journal · doi:10.1042/bj20141072 · Cited by 29 · see citing works

Protein Arginine Methyltransferase 6 Involved in Germ Cell Viability during Spermatogenesis and Down-Regulated by the Androgen Receptor

Luo, M., Li, Y., Guo, H., Lin, S., Chen, J., Ma, Q., Gu, Y., Jiang, Z., & Gui, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226186 · Cited by 25 · see citing works

Protein Arginine Methyltransferase 6 (Prmt6) Is Essential for Early Zebrafish Development through the Direct Suppression of gadd45αa Stress Sensor Gene

Zhao, X., Zhang, Y., Ni, P.-L., Wu, Z., Yan, Y., & Li, Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666347 · Cited by 24 · see citing works

Immunohistochemical and western analyses of protein arginine N-methyltransferase 3 in the mouse brain

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MicroRNA expression profiling in neurogenesis of adipose tissue-derived stem cells

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Differential regulation of T‐cell dependent and T‐cell independent antibody responses through arginine methyltransferase PRMT 1 in vivo

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Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors

Shlensky, D., Mirrielees, J. A., Zhao, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128143 · Cited by 16 · see citing works

Protein arginine Methyltransferase 8 gene is expressed in pluripotent stem cells and its expression is modulated by the transcription factor Sox2

Solari, C., Echegaray, C. V., Luzzani, C., Cosentino, M. S., Waisman, A., Petrone, M. V., Francia, M. G., Sassone, A. G., Canizo, J. R., Sevlever, G. E., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.077 · Cited by 16 · see citing works

Correction: Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors

Shlensky, D., Mirrielees, J. A., Zhao, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131955 · Cited by 2 · see citing works

The roles of DNA, RNA and histone methylation in ageing and cancer

Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549 · see citing works

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular &amp; Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works

The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells

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The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.

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Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4

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The activation of protein arginine methyltransferase PRMT5 promotes tumor development through Arginine methylation of HSP90A

Ichikawa, T. (2020) · The Japanese Biochemical Society

The Where and the How of PRMT5

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