Non-histone protein methylation as a regulator of cellular signalling and function
Abstract
Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair. With recent advances in proteomic techniques, in particular mass spectrometry, the stage is now set to decode the methylproteome and define its functions in health and disease.
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m6A in Xist RNA is required for it to mediate transcriptional repression.
“The effect may even be trans -acting, as exemplified by m6A in Xist RNA that is required for it to mediate transcriptional repression 40 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [40]
Tumour-intrinsic mechanisms of resistance to epigenetic therapies appear to be quite different from the paradigm of acquired resistance reported for other targeted therapies such as kinase inhibitors.
“Thus far the tumour-intrinsic mechanisms of resistance appear to be quite different to the paradigm of acquired resistance reported for other targeted therapies such as kinase inhibitors 188 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [188]
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- Authors
- Biggar, K. K., & Li, S. S.-C.
- Affiliations
- Western University (CA)
- Corresponding author
- Li, Shawn S.-C.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-12-10
- Volume
- 16
- Issue
- 1
- Pages
- 5-17
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2037215281
- Cited by
- 479
- References
- 138
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 35 · 2023: 39 · 2022: 44 · 2021: 31 · 2020: 51 · 2019: 56 · 2018: 46 · 2017: 46 · 2016: 54 · 2015: 21 · 2014: 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- non-histone protein methylation, lysine methylation, arginine methylation, post-translational modification crosstalk, histone methylation, MAPK signaling, Wnt signaling, BMP signaling, Hippo signaling pathway, JAK/STAT signaling, signal transduction, DNA repair, chromatin remodeling, gene transcription, proteomics
- MeSH terms
- Hippo Signaling Pathway, Animals, DNA Repair, Humans, Methylation, Transcription, Genetic, Protein Biosynthesis, Protein Serine-Threonine Kinases, MAP Kinase Signaling System, Chromatin Assembly and Disassembly, Extracellular Signal-Regulated MAP Kinases, STAT Transcription Factors, Wnt Proteins, Wnt Signaling Pathway
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