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Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation
Open accessAbstract
Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on chromatin structure is less understood. We characterized the organization of PcG target genes in ESCs and neural progenitors using 5C and super-resolution microscopy. The genomic loci of repressed PcG targets formed discrete, small (20-140 Kb) domains of tight interaction that corresponded to locations bound by canonical polycomb repressive complex 1 (PRC1). These domains changed during differentiation as PRC1 binding changed. Their formation depended upon the Polyhomeotic component of canonical PRC1 and occurred independently of PRC1-catalyzed ubiquitylation. PRC1 domains differ from topologically associating domains in size and boundary characteristics. These domains have the potential to play a key role in transmitting epigenetic silencing of PcG targets by linking PRC1 to formation of a repressive higher-order structure.
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“The spatial organization of chromatin, including a variety of long-range DNA interactions, plays a key role in controlling gene expression and maintaining cellular identity (Gorkin et al., 2014; Kundu et al., 2017; Narendra et al., 2015; Schoenfelder et al., 2015; Zirkel et al., 2018).”
From Loss of epigenetic information as a cause of mammalian aging (2023) · cites this paper as Kundu et al., 2017
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Cites
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“Data represented as mean ± SD. (E and F) HoxA and HoxD compaction domains are lost upon loss of canonical comprising HoxA (E) and HoxD (F) clusters in WT (left) and Phc1 KO (middle) ESCs Phc1 KO while Hi-C TADs are preserved.”
BackgroundInfluentialA bivalent chromatin structure marks key developmental genes in embryonic stem cells
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BackgroundRole of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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BackgroundA long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
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Shafiq, T. A., Yu, J., Feng, W., Zhang, Y., Zhou, H., Paulo, J. A., Gygi, S. P., & Moazed, D. (2024) · Science Advances · doi:10.1126/sciadv.adl4529 · Cited by 10
“H3K27me3 is also recognized by the CBX subunits of PRC1, which mediate chromatin compaction and silencing ( 34 – 36 ).”
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BackgroundSf3b4 regulates chromatin remodeler splicing and Hox expression
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ABI3 regulates ABI1 function to control cell length in primary root elongation zone
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Dror, I., Tan, T., & Plath, K. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2024.102235 · Cited by 8
Multitasking by Polycomb response elementsPreprint
Jaensch, E. S., Kundu, S., & Kingston, R. E. (2017) · Genes & Development · doi:10.1101/gad.303206.117 · Cited by 7
“interactions that place distant regions adjacent to one another by either looping or forming discrete domains of interaction (Deng et al. 2012; Williamson et al. 2012; Kundu et al. 2017).”
BackgroundSelf-citationProtein-DNA co-condensation is prewetting to a collapsed polymer
Rouches, M. N., & Machta, B. B. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.05.031 · Cited by 6
Acquisition of neural fate by combination of BMP blockade and chromatin modification
Ong, A. L. C., Kokaji, T., Kishi, A., Takihara, Y., Shinozuka, T., Shimamoto, R., Isotani, A., Shirai, M., & Sasai, N. (2023) · iScience · doi:10.1016/j.isci.2023.107887 · Cited by 7
“In this regard, to further survey the correlations between Phc1 and other PRC factors as well as histone modifications by H3K27me3 and H2K119ub1 (repressive marks), we compared our ATAC-seq data with publicly available Chromatin Immunoprecipitation and sequencing (ChIP-seq) data.(57) The peaks occupied by Ezh2 and Rin…”
MethodResultKrug, B., Hu, B., Chen, H., Negrón-Lomas, C., Chen, X., Mouatani, A. E., Gretarsson, K. H., Ptack, A., Deshmukh, S., Kabir, N., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02586-y · Cited by 9
“…studies 27,28 , these Polycomb long-range loops arise during the transition from naive to primed pluripotency 29 , and many of the 3D chromatin interactions between Polycomb targets are lost as cells exit embryonic and somatic progenitor states and differentiate into specialized cell types 30,31 .”
Self-citationMircea, M., & Semrau, S. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210135 · Cited by 9
Novel biological insights revealed from the investigation of multiscale genome architecture
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BackgroundAmin, A., Kadam, S., Mieczkowski, J., Ahmed, I., Bhat, Y. A., Fouziya, S., Tolstorukov, M. Y., Kingston, R. E., Padinhateeri, R., & Wani, A. H. (2023) · Life Science Alliance · doi:10.26508/lsa.202201768 · Cited by 7
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“1C), consistent with the model that H2Aub level is positively associated with chromatin compaction [22, 23].”
Subnuclear distribution of proteins: Links with genome architecture
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“An elegant in situ Hi-C study showed that TADs are composed of sub-TADs which have an average size of 185 kb.9 5C analysis of different genomic loci at early developmental stages have identified sub-TADs some of which get rearranged during differentiation of embryonic stem cells (ESCs) to neuronal progenitor cells (NP…”
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Epigenomic dynamics of early Xenopus Embryos
Zhou, J. J., & Cho, K. W. Y. (2022) · Development Growth & Differentiation · doi:10.1111/dgd.12813 · Cited by 5
“Clusters of genomic regions enriched with H3K27me3 can function as silencers by forming repressive intra- chromatin loops (Cai et al., 2021; Kundu et al., 2017).”
BackgroundMbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman
Nishioka, K., Wang, X., Miyazaki, H., Soejima, H., & Hirose, S. (2018) · Development · doi:10.1242/dev.162461 · Cited by 6
“Polycomb silencing is essential for the developmental regulation of gene expression (Grossniklaus and Paro, 2014; Comet et al., 2016; Kundu et al., 2017).”
BackgroundPolycomb Assemblies Multitask to Regulate Transcription
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“Of note, clustering mediated by these contacts is affected only partially by inactivating mutations in the core subunits (RING1 proteins or EED) of Polycomb catalytic modules [107], underscoring their independence on histone modifications.”
BackgroundInfluentialRe-evaluating the role of nucleosomal bivalency in early developmentPreprint
Shah, R. N., Grzybowski, A. T., Elias, J., Chen, Z., Hattori, T., Lechner, C. C., Lewis, P. W., Koide, S., Fierz, B., & Ruthenburg, A. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.09.458948 · Cited by 6
“Methyltransferase 904 reactions were done using following concentrations of the enzymatic complexes: 200 nM 905 hsMLL1(3745-3969), 200 nM hsMLL2(5319-5537), 400 nM hsMLL3(4689-4911), 200 nM 906 hsMLL4(2490-2715), 800 nM hsSet1A(1418-1707), 800 nM hsSet1B(1629-1923), in a complex 907 with hsWDR5(22-334), haRbBP5(1-538)…”
Polycomb repression of Hox genes involves spatial feedback but not domain compaction or demixingPreprint
Murphy, S. E., & Boettiger, A. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.14.512199 · Cited by 6
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RADIP technology comprehensively identifies H3K27me3-associated RNA–chromatin interactions
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“…of self-interacting domains of compacted chromatin (“Polycomb domains”) (Eskeland et al. 2010; Bantignies et al. 2011; Schoenfelder et al. 2015; Kundu et al. 2017), the attenuated inter-subTAD interactions might be attributable to weakening of Polycomb domains that normally span TAD/subTAD…”
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Phase Separation in Chromatin Organization and Human Diseases
Zhai, Z., Meng, F., Kuang, J., & Pei, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115156 · Cited by 4
“Hi-C studies show that polycomb repressive complexes (PRC1/2) form transcriptionally repressive loops at enhancer-promoter or promoter-promoter regions [68–71], which further compact into polycomb-associated domains (PADs) to silence genes during development in mouse and drosophila [72–75].”
The functions of polycomb group proteins in T cells
Li, T. (2022) · Cell Insight · doi:10.1016/j.cellin.2022.100048 · Cited by 4
“From studies using 5C and super-resolution microscopy, gene loci repressed by PRC1 forms isolated self-interacting domains mediated by PRC1 in pluripotent ESCs (Kundu et al., 2017).”
BackgroundScalisi, S., Ahmad, A., D’Annunzio, S., Rousseau, D., & Zippo, A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3143-0_14 · Cited by 4
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“Hence, defining the 3D-organization of cancerassociated chromatin domains could represent a new frontier to decipher tumor heterogeneity during tumor progression and metastasis formation (Kundu et al., 2017; Boettiger et al., 2016; Stevens et al., 2017).”
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“PRC1-generated compaction has been demonstrated and elucidated in mESCs [68-71] and 431 Pax6 has recently been identified as a PRC target in this context too [72].”
BackgroundIdentification of a Nonsense-Mediated Decay pathway at the Endoplasmic ReticulumPreprint
Longman, D., Jackson-Jones, K. A., Maslon, M. M., Murphy, L. C., Young, R. S., Stoddart, J. J., Taylor, M. S., Papadopoulos, D. K., & Cáceres, J. F. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.24.954453 · Cited by 4
Polymer Collapse & Liquid-Liquid Phase-Separation are Coupled in a Generalized Prewetting TransitionPreprint
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“The complex interactions between the sequence of regulatory elements and cell-type specific transcription factors could regulate transcription by determining which regions are prewet by transcriptionally inaccessible phases [28, 29].”
BackgroundH2AK119ub dynamics control hair follicle stem cell quiescence
Flora, P., Li, M.-Y., Zhou, Y., Mercedes, M. D. P. H., Zheng, X. Y., Galbo, P. M., Zheng, D., & Ezhkova, E. (2025) · Nature Communications · doi:10.1038/s41467-025-66471-8 · Cited by 5
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“H3K27me3 is a known feature of silencers [17,23,24].”
BackgroundBinder and monomer valencies determine the extent of collapse and reswelling of chromatin
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Polycomb-mediated 3D chromatin interactions in gene regulation
Kim, S., Huseyin, M. K., & Hansen, A. S. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102448 · Cited by 2
Epigenetic mechanisms of inflammatory memory in the central nervous system
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Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC)
Huseyin, M. K., Hong, C. K. Y., Nagano, M., Drayton, J. A., Jusuf, J. M., Yang, J., Ramanathan, V., Goel, V. Y., Kim, S. Y., & Hansen, A. S. (2026) · Nature Protocols · doi:10.1038/s41596-026-01393-3 · Cited by 3
On the Advent of Super-Resolution Microscopy in the Realm of Polycomb Proteins
Nepita, I., Piazza, S., Ruglioni, M., Cristiani, S., Bosurgi, E., Salvadori, T., Vicidomini, G., Diaspro, A., Castello, M., Cerase, A., et al. (2023) · Biology · doi:10.3390/biology12030374 · Cited by 2
“leveraging 3D STORM spatial resolution [80].”
BackgroundInfluentialToward a comprehensive view of gene architecture during transcription
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Tsujimura, T., Takase, O., Yoshikawa, M., Sano, E., Hayashi, M., Takato, T., Toyoda, A., Okano, H., & Hishikawa, K. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0221-1 · Cited by 2
A Finer Print Than TADs: PRC1-Mediated Domains
Triglia, E. T., Rito, T., & Pombo, A. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.028 · Cited by 2
Chromosome Conformation Capture
McLaughlin, K. (2018) · Materials and Methods · doi:10.13070/mm.en.8.2662 · Cited by 2
Monitoring the prolonged Tnf stimulation in space and time with topological-functional networks
Papoudas, S. M., Papanikolaou, N., & Nikolaou, C. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.01.001 · Cited by 2
“…we cannot exclude that it may be a particular characteristic of the system under study, it is worth noticing that repressive domains are readily formed in eukaryotic genomes mediated by Polycomp-Group (PcG) proteins [44] or through the association of genomic regions with the nuclear lamina [45].”
Osnato, A., Brown, S. E., & Vallier, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.14.150748 · Cited by 2
Dimitrova, E., Feldmann, A., van der Weide, R. H., Flach, K. D., Lastuvkova, A., de Wit, E., & Klose, R. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.04.467119 · Cited by 2
Ji, F., Kundu, S., Anselmo, A. N., Morris, A., Ducasse, A., Ergün, A., Kingston, R. E., & Sadreyev, R. I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.15.654384 · Cited by 2
“ChIP-seq enrichment profiles over individual TSS-proximal regions (TSS ± 10 Kb) for MLL2 [36] and Kdm2b [39] (center) compared to core TrxG components (Ash2l and Cxxc1 [36], left), and PcG proteins (Ring1b [71], Cbx7 [41], and Ezh2 [38], right).”
Self-citationDiscordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
Boston, A. M., Dwead, A. M., Al‐Mathkour, M. M., Khazaw, K., Zou, J., Zhang, Q., Wang, G., & Cinar, B. (2023) · iScience · doi:10.1016/j.isci.2023.107964 · Cited by 1
Modulation of AAV transduction and integration targeting by topoisomerase poisons
Kasimsetty, A., Hwang, Y., Everett, J. K., McFarland, A. G., Zolnoski, S. A., Lu, T., Roche, A. M., Martínez‐García, P. M., Sabatino, D. E., & Bushman, F. D. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101364 · Cited by 2
Martín-González, A., Paraíso‐Luna, J., Niñerola, S., del Blanco, B., Robles, R. M., Herrera, M. L., Muñoz‐Viana, R., Geijo‐Barrientos, E., & Barco, Á. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116201 · Cited by 2
Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation
Niekamp, S., Marr, S. K., Sanon, R., Schneider, P. C., Subramanian, R., & Kingston, R. E. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.04.001 · Cited by 1
Self-citationSabarís, G., Stefano, M. D., Denaud, S., Fritsch, L., Popmihaylova, A.-M., Papadopoulos, G. L., Schuettengruber, B., & Cavalli, G. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag512 · Cited by 2
“This domain is crucial for the condensation of individual Polycomb domains [ 25 ], and for mediating long-range Polycomb domain interactions in mammals [ 26–28 ].”
Polycomb-mediated 3D-genome organization controls replication timing
Chetlangia, N., Thakur, B. L., Redon, C. E., Zinder, O. J., Mishra, M., Liu, D., Pongor, L. S., Song, Y. J., Asoudegi, D., Fields, C. J., et al. (2026) · Science Advances · doi:10.1126/sciadv.adx7445 · Cited by 1
PRC1 nanoglobules organize Hox chromatin during Drosophila embryogenesis
Cheutin, T., Akilli, N., Stefano, M. D., Puel, P.-S., Fritsch, L., Jost, D., & Cavalli, G. (2026) · Cell Discovery · doi:10.1038/s41421-026-00902-8 · Cited by 1
“Although there is evidence that polycomb-dependent silent chromatin is more compacted than the same genomic regions in cells in which the corresponding genes are expressed 18,21 , the mechanism of compaction is more controversial 22,23 .”
cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes
Hanafiah, A., Geng, Z., Liu, T., Tai, Y. T., Cai, W., Wang, Q. Y., Christensen, N., Liu, Y., Yue, F., & Gao, Z. (2026) · EMBO Reports · doi:10.1038/s44319-026-00885-3 · Cited by 4
“The Hoxb and Pax6 loci have been shown in previous studies to be targeted by loops dependent on PRC1 (Kundu et al, 2017).”
InfluentialJoubert, P. M., Vlasov, A., Janakievski, N., Sanabria, M., & Poetsch, A. R. (2026) · Bioinformatics · doi:10.1093/bioinformatics/btag602 · Cited by 1
“H3K9me3 (Li and Zhang 2024) and H3K27me3 (Bernstein et al. 2006, Ayrapetov et al. 2014, Kundu et al. 2017), which mark constitutive and facultative heterochromatin, respectively, both play a role in DSB repair (Ayrapetov et al. 2014, Zhang et al. 2018, Li and Zhang 2024).”
The 3D Genome: EZH2 Comes into the Fold
Brien, G. L., & Bracken, A. P. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.013 · Cited by 1
Untangling the Epigenetic Imbalance in B cell Lymphoma
Wu, R. (2020) · Current Pharmacology Reports · doi:10.1007/s40495-020-00214-9 · Cited by 1
Sorting cells from fluorescent markers organization in confocal microscopy: 3D versus 2D images
Ahmad, A., Frindel, C., & Rousseau, D. (2020) · International Conference on Image Processing Theory, Tools and Applications (IPTA) · doi:10.1109/ipta50016.2020.9286463 · Cited by 1
“Distinct diseases like tumor or metastases may be characterized by specific chromatin modifications and by DNA spatial redistribution in chromatin domain [10], [11].”
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Imaging chromatin interactions at sub-kilobase resolution Via Tn5-FISHPreprint
Zhang, X., Niu, J., Li, G., Dai, Q., Jin, D., Gao, J. T., & Zhang, M. Q. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/601690 · Cited by 1
Temporal scaling in developmental gene networks by epigenetic timing controlPreprint
Nguyen, P. H., Pease, N. A., Ng, K. K. H., Irwin, B., & Kueh, H. Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/752170 · Cited by 1
“…between these modification states and higher order chromatin structure at individual gene loci, work that will be aided by new methods to simultaneously visualize histone modification states and chromatin folding at single gene loci in single cells (Kundu et al., 2017; Xu et al., 2018).”
BackgroundConway, E., Rossi, F., Tamburri, S., Ponzo, E., Ferrari, K. J., Zanotti, M., Fernández-Pérez, D., Manganaro, D., Rodighiero, S., & Pasini, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.10.419309 · Cited by 1
“Whether H2AK119ub1 actually plays a role in this process has been unclear due to the use of hypomorphic mutants of RING1B to date (Boyle et al., 2020; Kundu et al., 2017).”
BackgroundNewly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent StatesPreprint
Shao, R., Kumar, B., Lidschreiber, K., Lidschreiber, M., Cramer, P., & Elsässer, S. (2021) · bioRxiv · doi:10.1101/2021.06.11.448016
Nucleation and Spreading Rejuvenate Polycomb Domains Every Cell CyclePreprint
Veronezi, G. M. B., & Ramachandran, S. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4193114 · Cited by 1
Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiationPreprint
Kim, J. J., Steinson, E. R., Lau, M. S., Page, D. C., & Kingston, R. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.25.505322 · Cited by 1
Self-citationThree rules for epigenetic inheritance of human Polycomb silencingPreprint
Shafiq, T. A., & Moazed, D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.27.530239 · Cited by 1
Majumdar, S., Bammidi, L. S., Naik, H., Avinchal, Baro, R., Kalita, A., Sundarraj, N., Bariha, G., Notani, D., & Gayen, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.14.553118 · Cited by 1
Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neuronsPreprint
Pletenev, I. A., Vaulin, N., Molodova, M. N., Kuznechenkova, E., Soldatenkova, A., Efimova, O., Tvorogova, A. V., Khaitovich, P., Razin, S. V., Ulianov, S. V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.05.686502 · Cited by 1
“…chromatin interactions due to its ability to polymerize and form liquid condensates [Boyle et al., 2020, Eskeland et al., 2010, Tatavosian et al., 2019, Kundu et al., 2017, Blackledge and Klose, 2021], and PRC1 binding sites do not always overlap with H3K27me3 domains [Loubiere et al., 2020].”
Cheutin, T., & Cavalli, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/250183
“PcG proteins affect both Hox gene expression and 28 chromatin compaction of Drosophila and mammalian Hox gene clusters [11, 12, 17].”
BackgroundPolycomb repressive complex 1 defines the nucleosome landscape but not accessibility at target genesPreprint
King, H. W., & Klose, R. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/280305
Shaping Up the Embryo: The Role of Genome 3D Organization
Jácome-López, K., & Furlan-Magaril, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7714-7_15
Control and Function of Histone H3 Lysine 27 Methylation in Neurospora crassa
McNaught, K. J. (2020) · Scholars' Bank (University of Oregon)
Effects of forced cohesin eviction and retention on X-inactivation and autosomesPreprint
Kriz, A. J., Colognori, D., Sunwoo, H., Nabet, B., & Lee, J. T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.13.426565
“Insofar as Polycomb domains have an inherent tendency to cluster (Bonev and Cavalli, 2016; Denholtz et al., 2013; Joshi et al., 2015; Kundu et al., 2017; McLaughlin et al., 2019; Rhodes et al., 2020; Schoenfelder et al., 2015; Vieux-Rochas et al., 2015), we propose that a key role of cohesins is to…”
BackgroundSelf-citationCell Fate and Organogenesis in Asxl3 Mouse Model
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Wen, Z., Zhang, W., Zhong, Q., Xu, J., Hou, C., Qin, Z. S., & Li, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.17.460762
“A recent study (Kundu et al. 2017) based on 5C using ESCs revealed PRC1-mediated self-interacting domains that are similar to TADs but smaller in size.”
BackgroundBartholomew, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733365277.793562641
Metadata
- Authors
- Kundu, S., Ji, F., Sunwoo, H., Jain, G., Lee, J. T., Sadreyev, R. I., Dekker, J., & Kingston, R. E.
- Affiliations
- Harvard University (US)
- University of Massachusetts Chan Medical School (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kingston, Robert E.
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 65
- Issue
- 3
- Pages
- 432-446.e5
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC5421375
- OpenAlex
- W2585920126
- Cited by
- 333
- References
- 73
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 27 · 2023: 23 · 2022: 45 · 2021: 55 · 2020: 41 · 2019: 48 · 2018: 35 · 2017: 17
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Update notices
- erratum (2018-07-05)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- National Institutes of Health (5R01GM043901-24, DK107980, HG003143, P30 DK40561, R01-GM090278)
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- PRC1, Polycomb group proteins, chromatin condensation, polyhomeotic, epigenetic silencing, chromatin looping, topologically associating domains, neural progenitor cells, embryonic stem cells, cell differentiation, chromatin organization, higher-order chromatin structure
- MeSH terms
- Protein Domains, Animals, Cell Differentiation, Cells, Cultured, Chromatin, DNA, Histones, Humans, Homeodomain Proteins, Gene Expression Regulation, Developmental, Epigenesis, Genetic, Mice, Embryonic Stem Cells, Ubiquitination, Neural Stem Cells, Polycomb Repressive Complex 1
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