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Cited by 231

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity

Open access
Dong, Zhiwei, Shanmughapriya, Santhanam, Tomar, Dhanendra, Siddiqui, Naveed, Lynch, Solomon, Nemani, Neeharika, Breves, Sarah L., Zhang, Xueqian, Tripathi, Aparna, Palaniappan, Palaniappan, Riitano, Massimo F., Worth, Alison M., Seelam, Ajay, Carvalho, Edmund, Subbiah, Ramasamy, Jaña, Fabián, Soboloff, Jonathan, Peng, Yizhi, Cheung, Joseph Y., Joseph, Suresh K., Caplan, Jeffrey, Rajan, Sudarsan, Stathopulos, Peter B., Madesh, Muniswamy·2017·Molecular Cell
DOI 10.1016/j.molcel.2017.01.032
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Abstract

SUMMARY Ca2+ dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether and how these coactive elements interact with MCU has not been established. As an approach towards understanding the regulation of MCU channel by oxidative milieu, we adapted inflammatory and hypoxia models. We identified the conserved cysteine 97 to be the only reactive thiol in human MCU that undergoes S-glutathionylation. Furthermore, biochemical, structural and superresolution imaging analysis revealed that MCU oxidation promotes MCU higher-order oligomer formation. Both oxidation and mutation of MCU Cys-97 exhibited persistent MCU channel activity with higher [Ca2+]m uptake rate, elevated mROS and enhanced [Ca2+]m overload-induced cell death. In contrast, these effects were largely independent of MCU interaction with its regulators. These findings reveal a distinct functional role for Cys-97 in ROS sensing and regulation of MCU activity.

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Metadata

Authors
Dong, Z., Shanmughapriya, S., Tomar, D., Siddiqui, N., Lynch, S., Nemani, N., Breves, S. L., Zhang, X., Tripathi, A., Palaniappan, P., Riitano, M. F., Worth, A. M., Seelam, A., Carvalho, E., Subbiah, R., Jaña, F., Soboloff, J., Peng, Y., Cheung, J. Y., Joseph, S. K., Caplan, J., Rajan, S., Stathopulos, P. B., & Madesh, M.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2017-03
Volume
65
Issue
6
Pages
1014-1028.e7
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2017.01.032
OpenAlex
W2594111041
Cited by
231
References
7
FWCI
9.80
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. https://app.cochat.ai/papers/10.1016/j.molcel.2017.01.032
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Dong, Z., Shanmughapriya, S., Tomar, D., Siddiqui, N., Lynch, S., Nemani, N., Breves, S. L., Zhang, X., Tripathi, A., Palaniappan, P., Riitano, M. F., Worth, A. M., Seelam, A., Carvalho, E., Subbiah, R., Jaña, F., Soboloff, J., Peng, Y., Cheung, J. Y., . . . Madesh, M. (2017). Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. Molecular Cell. https://doi.org/10.1016/j.molcel.2017.01.032

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.