The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Interrelation between ROS and Ca2+ in aging and age-related diseases
Open accessAbstract
Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca2+ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by various production sites within the cell. Ca2+ controls membrane potential, modulates mitochondrial adenosine triphosphate (ATP) production and affects proteins like calcineurin (CaN) or calmodulin (CaM), which, in turn, have a wide area of action. Overwhelming Ca2+ levels within mitochondria efficiently induce and trigger cell death. In contrast, ROS comprise a diverse group of relatively unstable molecules with an odd number of electrons that abstract electrons from other molecules to gain stability. Depending on the type and produced amount, ROS act either as signaling molecules by affecting target proteins or as harmful oxidative stressors by damaging cellular components. Due to their wide range of actions, it is little wonder that Ca2+ and ROS signaling pathways overlap and impact one another. Growing evidence suggests a crucial implication of this mutual interplay on the development and enhancement of age-related disorders, including cardiovascular and neurodegenerative diseases as well as cancer.
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Reproductive Toxicity of Per- and Polyfluoroalkyl Substances
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Metadata
- Authors
- Madreiter-Sokolowski, C. T., Thomas, C., & Ristow, M.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 36
- Pages
- 101678
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W3047644615
- Cited by
- 365
- References
- 185
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A_176127)
- Horizon 2020 (633589)
- Austrian Science Fund (J4205-B27)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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