Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

Burke, John E.·2018·Molecular Cell

Cited by (278)

Items 101–200 of 278

  1. Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent
    Silvia Arcucci, Fernanda Ramos‐Delgado, Coralie Cayron, Nicole Therville, Marie‐Pierre Gratacap, Céline Basset, Benoît Thibault, Julie Guillermet‐Guibert · 2021 · Biochemical Journal
  2. Molecular basis for plasma membrane recruitment of PI4KA by EFR3
    Sushant Suresh, Alexandria L Shaw, Joshua G. Pemberton, Mackenzie K. Scott, Noah J Harris, Matthew AH Parson, Meredith L. Jenkins, Pooja Rohilla, Alejandro Álvarez-Prats, Tamás Balla et al. · 2024 · Science Advances
  3. The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi
    Aya Mizuike, Shota Sakai, Kaoru Katoh, Toshiyuki Yamaji, Kentaro Hanada · 2023 · The Journal of Cell Biology
  4. Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects
    Jiarui Hu, Siyu Fu, Zixuan Zhan, Jifa Zhang · 2023 · European Journal of Medicinal Chemistry
  5. Whole-Genome Sequencing Analysis of Male Breast Cancer Unveils Novel Structural Events and Potential Therapeutic Targets
    Majd Al Assaad, Olivier Michaud, Alissa Semaan, Michael Sigouros, Marvel Tranquille, Andy V. Phan, Max Fine Levine, Gunes Gundem, Juan Santiago Medina-Martinez, Elli Papaemmanuil et al. · 2024 · Modern Pathology
  6. Divergent roles of the regulatory subunits of class IA PI3K
    Cho‐Won Kim, Junsik M. Lee, Sang Won Park · 2024 · Frontiers in Endocrinology
  7. Therapeutic Role of Synthetic Lethality in ARID1A -Deficient Malignancies
    Kyaw Zaw Hein, Bettzy Stephen, Siqing Fu · 2023 · Journal of Immunotherapy and Precision Oncology
  8. PIP kinases: A versatile family that demands further therapeutic attention
    Alicia Llorente, Gurpreet K. Arora, Shea F. Grenier, Brooke M. Emerling · 2022 · Advances in Biological Regulation
  9. Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model
    Pallavi Mathur, Camilla de Barros Santos, Hugo Lachuer, Julie Patat, Bruno Latgé, F. Radvanyi, B. Goud, Kristine Schauer · 2023 · Communications Biology
  10. PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
    Tamara A. M. Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E. Anderson, David Barneda, Anna Kielkowska, Barzan A. Sadiq, Ieng Wai Lai, Sérgio Luís Felisbino et al. · 2023 · Molecular Cell
  11. Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease
    Xi Fu, Kathy Nga-Chu Lui, Clara Sze-Man Tang, Ray Kit Ng, Frank Pui-Ling Lai, Sin-Ting Lau, Zhixin Li, María-Mercé García-Barceló, Pak Chung Sham, Paul Kwong Hang Tam et al. · 2020 · Genome Research
  12. Crucial Players for Inter-Organelle Communication: PI5P4Ks and Their Lipid Product PI-4,5-P2 Come to the Surface
    Archna Ravi, Lavinia Palamiuc, Brooke M. Emerling · 2022 · Frontiers in Cell and Developmental Biology
  13. Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease
    Sushant Suresh, John E. Burke · 2023 · Advances in Biological Regulation
  14. CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance
    Naji Kharouf, Thomas Wayne Flanagan, Abdulhadi A. AlAmodi, Youssef Al Hmada, Sofie-Yasmin Hassan, Hosam Shalaby, Simeon Santourlidis, Sarah-Lilly Hassan, Youssef Haïkel, Mossad Megahed et al. · 2024 · Cells
  15. Structural Cues for Understanding eEF1A2 Moonlighting
    Alejandra Angela Carriles, Alberto Mills, María‐José Muñoz‐Alonso, Dolores Gutiérrez, Juan Manuel Domı́nguez, J.A. Hermoso, Federico Gago · 2020 · ChemBioChem
  16. Development of potent and selective degraders of PI5P4Kγ
    Wenzhi Ji, Eric S. Wang, Theresa D. Manz, Jie Jiang, Katherine A. Donovan, Xianmixinuer Abulaiti, Eric S. Fischer, Lewis C. Cantley, Tinghu Zhang, Nathanael S. Gray · 2022 · European Journal of Medicinal Chemistry
  17. PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells
    Ajit Roy, Arup R. Chakraborty, Tyzoon K. Nomanbhoy, Melvin Depamphilis · 2023 · Autophagy
  18. A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P2
    Ana Bura, Sara Čabrijan, Iris Đurić, Tea Bruketa, Antonija Jurak Begonja · 2023 · Cells
  19. Effects of Rosa roxburghii Tratt on Ulcerative Colitis: An Integrated Analysis of Network Pharmacology and Experimental Validation
    Yu-Hong Kang, Ting Jin Zhou, Shouxun Wu, Xingjie Li, Xiaoyi Huang, Rui Xia, Yi-Han Ling, He-Ting Zhou, Shuwen Zhang, Wenya Yin · 2023 · The American Journal of Chinese Medicine
  20. Probing and imaging phospholipid dynamics in live cells
    Zhongsheng Wu, Yongtao Du, Tomas L. Kirchhausen, Kangmin He · 2024 · Life Metabolism
  21. Coumarin Derivative N6 as a Novel anti-hantavirus Infection Agent Targeting AKT
    Zhoupeng Li, Fang Wang, Yongsheng Liu, Dongshen Zhai, Xiaoxiao Zhang, Qikang Ying, Min Jia, Xiaoyan Xue, Jingru Meng, Jing Li et al. · 2021 · Frontiers in Pharmacology
  22. The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity
    Koh Takeuchi, Yoshiki Ikeda, Miki Senda, Ayaka Harada, Koji Okuwaki, Kaori Fukuzawa, So Nakagawa, Hong Yang Yu, Lisa Nagase, Misaki Imai et al. · 2022 · Structure
  23. Emerging Prospects for Combating Fungal Infections by Targeting Phosphatidylinositol Transfer Proteins
    Danish Khan, Aaron H. Nile, Ashutosh Tripathi, Vytas A. Bankaitis · 2021 · International Journal of Molecular Sciences
  24. Sophora Flos extract ameliorates inflammatory bowel disease via inhibiting the PI3K/AKT/mTOR signaling pathway activation and modulating M1/M2 polarization in macrophages
    Anhong Li, Yuxiao Niu, Wei‐Hua Xu, Bingqing Liang, Rong Zhang, Ruya Mei, Xinyue Zhang, Tong Zhang, Yun Gao, Yuzhong Yan · 2025 · Phytomedicine
  25. Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells
    Cong Si Tran, Julia Kersten, Jingyi Yan, Marco Breinig, Thorben Huth, Tanja Poth, Ombretta Colasanti, Tobias Riedl, Suzanne Faure‐Dupuy, Stefan Diehl et al. · 2024 · Gastroenterology
  26. Rab1b-GBF1-ARF1 Secretory Pathway Axis Is Required for Birnavirus Replication
    María C. Gimenez, Yesica Romina Frontini-López, Cristian A. Pocognoni, Julieta S. Roldán, Clara García Samartino, Marina Uhart, María I. Colombo, Mauricio R. Terebiznik, Laura Ruth Delgui · 2021 · Journal of Virology
  27. Dynamic structural biology at the protein membrane interface
    John E. Burke · 2019 · Journal of Biological Chemistry
  28. Host Cell Signatures of the Envelopment Site within Beta-Herpes Virions
    Hana Mahmutefendić Lučin, Gordana Blagojević Zagorac, Marina Marcelić, Pero Lučin · 2022 · International Journal of Molecular Sciences
  29. Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability
    B. Vanhaesebroeck, B. Bilanges, R. Madsen, Katie L. Dale, Evelyn Lau, Elina Vladimirou · 2019 · Biomolecules
  30. Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention
    Alicia Llorente Lope, Ryan M. Loughran, Brooke M. Emerling · 2023 · Frontiers in Cell and Developmental Biology
  31. PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity
    Zu Ye, Chee Ping Ng, Haidong Liu, Qimei Bao, Shengfeng Xu, Dan Zu, Yanhua He, Yixing Huang, Abdul Qader Al-Aidaroos, Ke Guo et al. · 2024 · Theranostics
  32. Molecular Basis of Oncogenic PI3K Proteins
    Zhi Sheng, Patrick J. Beck, Maegan E. Gabby, Semhar Habte-Mariam, Katherine Mitkos · 2024 · Cancers
  33. Using Phosphatidylinositol Phosphorylation as Markers for Hyperglycemic Related Breast Cancer
    Nirupama Devanathan, Sandra Renee Jones, Gursimran Kaur, Ann C. Kimble-Hill · 2020 · International Journal of Molecular Sciences
  34. Phosphoinositide species and filamentous actin formation mediate engulfment by senescent tumor cells
    Wesley D. Frey, Ashlyn Y. Anderson, Hyemin Lee, Julie B. Nguyen, Emma Cowles, Hua Lu, James G. Jackson · 2022 · PLoS Biology
  35. Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ
    Yu Sun, Kate T. Stenson, Maradumane L. Mohan, Manveen Kaur Gupta, Nicholas Wanner, Kewal Asosingh, SERPIL CEM ERZURUM, Sathyamangla V Naga Prasad · 2023 · Circulation Research
  36. Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55 Gag to the Plasma Membrane
    Baptiste Gonzales, Hugues de ROCQUIGNY, Anne Beziau, Stephanie Durand, Julien Burlaud‐Gaillard, Antoine Lefebvre, Sandra Krull, Patrick Emond, Denys Brand, Éric Piver · 2020 · Journal of Virology
  37. Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis
    Fernando Montaño-Rendón, Sergio Grinstein, Glenn F. W. Walpole · 2021 · Frontiers in Cell and Developmental Biology
  38. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
  39. Oxidative Cyclization‐Induced Activation of a Phosphoinositide 3‐Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics
    Haizhou Zhu, Rosalin Mishra, Long Yuan, Safnas F. AbdulSalam, Jing L. Liu, George Gray, Alyssa Sterling, Mark Wunderlich, Julio Alberto Landero Figueroa, Joan T. Garrett et al. · 2019 · ChemMedChem
  40. Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback
    Benjamin R. Duewell, Katherine A. Faris, Scott D. Hansen · 2024 · Journal of Biological Chemistry
  41. Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease
    Alexandria L Shaw, Isobel Barlow-Busch, John E. Burke · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  42. Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
    Zhili Cheng, Magdalene K. Montgomery · 2025 · Clinical Science
  43. The membrane environment of cadherin adhesion receptors: a working hypothesis
    Jessica L. Teo, Robert G. Parton, Alpha S. Yap · 2019 · Biochemical Society Transactions
  44. Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3
    Christine E. Peters, Ursula Schulze‐Gahmen, Manon Eckhardt, Gwendolyn Μ. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Mélanie Ott, Or Gozani et al. · 2022 · Nature Communications
  45. High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats
    Yanyan Sun, Xing Quan Zhu, Kaiyi Zhu, Jie Yu, Lin Cheng, Mingyan Hei · 2022 · International Journal of Medical Sciences
  46. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
    Duewell, Benjamin R, Wilson, Naomi E, Bailey, Gabriela M, Peabody, Sarah E, Hansen, Scott D · 2024 · eLife
  47. Locational and functional characterization of PI4KB in the mouse embryo
    Haoyu Zhao, Fengyun Kong, Weikai Yu, Huijie Zhao, Jingjing Zhang, Jun Yu Zhou, Xiaoqian Meng · 2024 · Journal of Cellular Physiology
  48. Development of isotope-enriched phosphatidylinositol-4- and 5-phosphate cellular mass spectrometry probes
    Amélie M. Joffrin, Alex M. Saunders, David Barneda, Vikki Flemington, Amber L. Thompson, Hitesh J. Sanganee, Stuart J. Conway · 2020 · Chemical Science
  49. Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells
    Xiaoyan Hou, Lijun Qiao, Ruijuan Liu, Xuechao Han, Weifang Zhang · 2021 · Biomolecules
  50. Membrane Lipids in Epithelial Polarity: Sorting out the PIPs
    Katlynn Bugda Gwilt, Jay R. Thiagarajah · 2022 · Frontiers in Cell and Developmental Biology
  51. Regulation of phosphoinositide metabolism in Apicomplexan parasites
    Angela Arabiotorre, Vytas A. Bankaitis, Aby Grabon · 2023 · Frontiers in Cell and Developmental Biology
  52. Protect Effects of Perilla Seed Extract and Its Active Ingredient Luteolin Against Inflammatory Bowel Disease Model via the PI3K/AKT Signal Pathway In Vivo and In Vitro
    Jin Zhang, Linlu Zhao, Jieyi He, Huining Wu, Mengru Guo, Zhichao Yu, Xingbin Ma, Yanhong Yong, Youquan Li, Xianghong Ju et al. · 2025 · International Journal of Molecular Sciences
  53. Reciprocal regulation between AtFH5‐labeled secretory vesicles and PI(4,5)P2 oscillation at the plasma membrane directs pollen germination
    Yuwan Zhao, Zijing Huang, Ting Wang, Yi Zhang, Zhufeng Chen, Yihao Li, Haiyun Ren · 2025 · Journal of Integrative Plant Biology
  54. Cardiac and Nephrological Complications Related to the Use of Antiangiogenic and Anti-Programmed Cell Death Protein 1 Receptor/Programmed Cell Death Protein 1 Ligand Therapy
    Paulina Stachyra, Lidia Szatkowska-Sieczek, Paweł Cisek, Paweł Gołębiowski, Ludmiła Grzybowska‐Szatkowska · 2024 · Genes
  55. Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A
    Shaw, Alexandria L., Suresh, Sushant, Parson, Matthew A.H., Harris, Noah J., Jenkins, Meredith L., Yip, Calvin K., Burke, John E. · 2024 · Structure
  56. Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor
    Henriëtte M. G. Willems, Simon Edwards, Helen K. Boffey, Stephen J. Chawner, Christopher Green, Tamara Romero, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews · 2023 · RSC Medicinal Chemistry
  57. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
  58. Revealing the mechanism of Zanthoxylum armatum DC. extract-induced liver injury in mice based on lipidomics
    Nannan Yang, Jian Zhang, Jiafu Guo, Qiwen Xiang, Yan Huang, Jiayu Wen, Qiuyan Liu, Tingting Hu, Yan Chen, Chaolong Rao · 2023 · Journal of Ethnopharmacology
  59. Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice
    Bai He, Jian Wen, Jianping Gong, Hao Wu, Fangchao Yuan, Ding Cao, Yakun Wu, Xing Lai, Menghao Wang · 2019 · Autoimmunity
  60. Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor
    Yu Chen Cai, Jun Yu, Ping Ren, Jianlin He, Zhipeng Wu, Kun Xiao, Hong Jia, Jian Wang, Yang Sai, Guangxiu Dai et al. · 2020 · Pharmacology Research & Perspectives
  61. Bioinformatics for The Prognostic Value and Function of Cubilin (CUBN) in Colorectal Cancer
    Yibin Wu, Ye Xu · 2020 · Medical Science Monitor
  62. PIK3CA Mutations: Are They a Relevant Target in Adult Diffuse Gliomas?
    Ana Tomás, Marta Pojo · 2025 · International Journal of Molecular Sciences
  63. Loss of MiR-155 Sensitizes FLT3-ITD+AML to Chemotherapy and FLT3 Inhibitors via Glycolysis Blocking by Targeting PIK3R1
    Lingyan Wang, Peifang Jiang, Jiazheng Li, Yan Huang, Jingjing Wen, Zhengjun Wu, Yanxin Chen, Jianda Hu · 2023 · Journal of Cancer
  64. Signaling Pathways in Gliomas
    Paulina Stachyra, Ludmiła Grzybowska-Szatkowska · 2025 · Genes
  65. Short stature and combined immunodeficiency associated with mutations in RGS10
    Ivan Kingyue Chinn, Zhihui Xie, Eunice Ching Chan, Bianca M. Nagata, Alexey Koval, Wei‐Sheng Chen, Fan Zhang, Sundar Ganesan, Diana N. Hong, Motoshi Suzuki et al. · 2021 · Science Signaling
  66. Synthetic lethal kinases in Ras/p53 mutant squamous cell carcinoma
    Russell D. Moser, Kay E. Gurley, Olga H. Nikolova, Guangrong Qin, Rashmi Joshi, Eduardo Méndez, Ilya Shmulevich, Amanda K. Ashley, Carla Grandori, Christopher J. Kemp · 2022 · Oncogene
  67. Cryptotanshinone Reverses Corticosteroid Insensitivity by Inhibition of Phosphoinositide-3-Kinase-δ in Chronic Obstructive Pulmonary Disease
    Tao Xie, Rong Tan Huang, Daishuo Deng, Peipei Tang, Yufeng Fu, Yulong Zheng, Wan Ching Yu · 2023 · International Journal of COPD
  68. Glioblastoma molecular and histological heterogeneity
    Pavel V. Nikitin, Marina Vladimirovna Ryzhova, Potapov Aa, S.A. Galstyan, D.S. Kim, T N Panina, Svetlana Shugay, Д.В. Старовойтов, Е.А. Хохлова, Irina V. Zubova · 2020 · CLINICAL AND EXPERIMENTAL MORPHOLOGY
  69. The 3.2Å resolution structure of human mTORC2
    Alain Scaiola, Francesca Mangia, Stefan Imseng, Daniel Boehringer, Karolin Berneiser, Mitsugu Shimobayashi, Edward Stuttfeld, Michael N. Hall, Nenad Ban, Timm Maier · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Making PI3K superfamily enzymes run faster
    Grace Qun Gong, Madhanagopal Anandapadamanaban, Md. Saiful Islam, Iain M. Hay, Maxime Bourguet, Saulė Špokaitė, Antoine Nicolas Dessus, Yohei Ohashi, Olga Perišić, Roger L. Williams · 2024 · Advances in Biological Regulation
  71. Role of PI3Kγ in the polarization, migration, and phagocytosis of microglia
    Xinghua Liang, Yuan Hu, Xinyue Li, Xi Xu, Zhonglan Chen, Yalin Han, Yingying Han, Guang-Ping Lang · 2024 · Neurochemistry International
  72. The Influence of Phosphoinositide Lipids in the Molecular Biology of Membrane Proteins: Recent Insights from Simulations
    George Hedger, Hsin‐Yung Yen · 2025 · Journal of Molecular Biology
  73. ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding
    Grace Qun Gong, Glenn Robert Masson, Woo-Jeong Lee, James M. J. J. Dickson, Jackie D. Kendall, Manoj Kumar Rathinaswamy, Christina Maree Buchanan, Martin Middleditch, Brady M. Owen, Julie A. Spicer et al. · 2024 · Biochemical Journal
  74. A direct fluorometric activity assay for lipid kinases and phosphatases
    Jiachen Sun, Indira Singaram, Mona Hoseini Soflaee, Wonhwa Cho · 2020 · Journal of Lipid Research
  75. The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase
    2023
  76. Integrated proteomic and transcriptomic landscape of human placenta in small for gestational age infants
    Heyue Jin, Xianyan Wang, Ling-Yu Li, Chen Rui, H. Gan, Qu-Nan Wang, Fang-Biao Tao, Yu-Min Zhu · 2024 · iScience
  77. In vitro safety evaluation of dopamine D3R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder
    Rahul M. Nandre, Amy Hauck Newman, Pramod Terse · 2024 · PLoS ONE
  78. Computational discovery of novel PI3KC2α inhibitors using structure-based pharmacophore modeling, machine learning and molecular dynamic simulation
    Bana Katrib, Ahmed Adel, Mohammed M. Abadleh, Safa Daoud, Mutasem O. Taha · 2025 · Journal of Molecular Graphics and Modelling
  79. Epinephrine inhibits PI3Kα via the Hippo kinases
    Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina M. Liberatore, Louise Lantier, Neil Vasan, Kannan R. Karukurichi, Seo‐Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber et al. · 2023 · Cell Reports
  80. Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation
    Medhat Taha, Ahmed Alzahrani, Omer Abdelbagi, Rehab M. Bagadood, Naeem F. Qusty, Rami J. Obaid, Mohammad El-Nablaway, Tourki A. S. Baokbah · 2025 · Frontiers in Molecular Biosciences
  81. Noncanonical PI(4,5)P 2 coordinates lysosome positioning through cholesterol trafficking
    Ryan M. Loughran, Gurpreet K. Arora, Jiachen Sun, Alicia Llorente Lope, Sophia Crabtree, Cynthia Y. Zhang, Kyanh Ly, Ren-Li Huynh, Wonhwa Cho, Brooke E. Emerling · 2026 · Science Advances
  82. Roles of intrinsically disordered regions in phosphoinositide 3-kinase biocatalysis
    Vrushank Davé, Vladimir Nikolaevich Uversky · 2022 · Elsevier eBooks
  83. Activation of PKCβII through nuclear trafficking guided by βγ subunits of trimeric G protein and 14-3-3ε
    Xiao Min, Xiaohan Zhang, Shujie Wang, Kyeong‐Man Kim · 2022 · Life Sciences
  84. Membrane and Actin Tethering Transitions Help IQGAP1 Coordinate GTPase and Lipid Messenger Signaling
    Nicholaus J. Trenton, Robert T. McLaughlin, Satya K. Bellamkonda, David Tsao, Alexandra Rodzinski, Emily Margaret Mace, Jordan Scott Orange, Volker Schweikhard, Michael R. Diehl · 2019 · Biophysical Journal
  85. PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12
    Oscar Vadas, Simon Tiede, Maria Chaouki, Laura A. Tesmer, Shanlin Rao, Rémy Visentin, Ulrich Grädler, Martin Augustin, Reiner Kiefersauer, Carola Gößer et al. · 2026 · Nature Communications
  86. Negative Surface Charge and Membrane Lipid Composition Underlying Extracellular Vesicle Function
    Naohiro Seo, Takanori Ichiki · 2026 · ACS Nano Medicine
  87. Differential activation of the inositol 5-phosphatase SHIP2 by EGF and insulin signaling pathways
    Amir Damouni, Dániel J. Tóth, Szilvia Barsi, Dániel Károly Nagy, Alexander Kasbary, László Hunyady, Miklós Cserző, Péter Várnai · 2025 · Journal of Biological Chemistry
  88. PIK3R1 mutations in individuals with insulin resistance or growth retardation: Case series and in silico functional analysis
    Tomofumi Takayoshi, Yushi Hirota, Aki Sugano, Kenji Sugawara, Takehito Takeuchi, Mika Ohta, Kai Yoshimura, Seiji Nishikage, Akane Yamamoto, Yu Mimura et al. · 2025 · Journal of Diabetes Investigation
  89. Diverse activation mechanisms of PI3Ks
    Pujuan Deng, Junjie Liu · 2022 · Nature Structural & Molecular Biology
  90. Preclinical evaluation and phase 1 study of the PI3Kα/δ inhibitor TQ‐B3525 in Chinese patients with advanced cancers
    Zhiming Li, Xiang Li, Li Su, Rong Tao, Xin Tian, Fan Feng, Wenqi Jiang, Huaqing Wang · 2024 · Cancer
  91. PI 5 P 4 K inhibitors: promising opportunities and challenges
    Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka et al. · 2025 · FEBS Journal
  92. The inositol 5-phosphatases OCRL and INPP5B: Cellular functions and roles in disease
    Aloka De Sa, Gaoyu Li, Connor Byrne, Martin Lowe · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  93. A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
    Saulė Špokaitė, Yohei Ohashi, Maxime Bourguet, Antoine Nicolas Dessus, Roger Lee Williams · 2026 · eLife
  94. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
    Duewell, Benjamin R, Wilson, Naomi E, Bailey, Gabriela M, Peabody, Sarah E, Hansen, Scott D · 2024 · eLife
  95. Dichotomous roles of ACBD3 in NSCLC growth and metastasis
    Xiaochao Tan, Chao‐Liang Wu, Priyam Banerjee, Shike Wang, Derrick L. Cardin, Yuting Xu, Chad J. Creighton, William K. Russell · 2025 · Oncogene
  96. Activity and dynamics of p110α are not differentially modulated by regulatory subunit isoforms
    Isobel Barlow-Busch, Emma E. Walsh, Hunter G. Nyvall, John E. Burke · 2025 · Advances in Biological Regulation
  97. Spatial organization of phosphoinositide signaling
    Siyu Lai, Wenbo Huang, Kangmin He · 2025 · FEBS Letters
  98. A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant
    Alexandra Papafotika, Maria Pavlaki, Vasiliki Lazani, Vasiliki Elpida Karamani, Dimitris Aggelidis, Anna Kapella, Danai Maria Kotzampasi, Bogos Agianian, Argiris Efstratiadis, Zoe Cournia et al. · 2026 · Journal of Biological Chemistry
  99. The Interplay of Lipid Signaling in Musculoskeletal Cross Talk: Implications for Health and Disease
    Ahmed Al Saedi, Ahmed S. Yacoub, Kamal R. Awad, David Karasik, Marco Brotto, Gustavo Duque · 2024 · Methods in molecular biology
  100. Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications
    Mehrdad Hashemi, Asal Abolghasemi Fard, Bita Pakshad, Pezhman Shafiei Asheghabadi, Amineh Hosseinkhani, Atena Sadat Hosseini, Parham Moradi, Mohammadreza Mohammadbeygi Niye, Ghazal Najafi, Mohadeseh Farahzadi et al. · 2024 · Non-coding RNA Research