Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease

Burke, John E.·2018·Molecular Cell

Cited by (278)

Items 201–278 of 278

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  7. Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability
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  8. Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis
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  9. Research progress of small molecule protein kinase inhibitors (SMKIs) in the treatment of colorectal cancer: mechanism, application, and future prospects
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  10. Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor
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  11. The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)
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  13. Orthosteric–allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer
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  14. Investigating potential molecular mechanisms of serum exosomal miRNAs in colorectal cancer based on bioinformatics analysis
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  15. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
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  16. Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics
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  17. Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model
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  19. Epinephrine inhibits PI3K alpha via the Hippo kinases
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  21. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1
    Grace L. Waddell, Emma E. Drew, Henry P. Rupp, Scott D. Hansen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
    Duewell, Benjamin R., Wilson, Naomi E., Bailey, Gabriela M., Peabody, Sarah E., Hansen, Scott D. · 2023
  24. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
  25. Role and Future Directions of PI3K Inhibitors in Cancer Treatment
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  26. Reviewer #2 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    2023 · eLife
  27. Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    2023 · eLife
  28. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
  29. Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Noah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
  30. Author response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    2023 · eLife
  31. Reconstitution of ORP-mediated lipid exchange process coupled to PI(4)P metabolism
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  32. Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
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  33. Enhanced PI3K/Akt Signaling in Response to p85α Loss is Regulated by Endosomal PI3Kα and PI3P
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  34. Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosis
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  35. eLife Assessment: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain
    Amy Hamilton Andreotti · 2023 · eLife
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  42. Additional file 1 of Aqueous extract of Platycodon grandiflorus attenuates lipopolysaccharide-induced apoptosis and inflammatory cell infiltration in mouse lungs by inhibiting PI3K/Akt signaling
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  44. Phosphorylation of the C-terminus of PI4KA inhibits lipid kinase activity
    Alexandria L Shaw, Sophia Doerr, Hunter G. Nyvall, Meredith L. Jenkins, Sushant Suresh, Calvin K. Yip, Scott D. Hansen, John E. Burke · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
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  46. Identification d'une déficience humaine en SEC14L2 révélant son rôle dans le système immunitaire
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  72. BindingDB Entry 50019333: The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.
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  73. BindingDB Entry 50016594: Kinase Inhibitors as Underexplored Antiviral Agents.
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  74. BindingDB Entry 50020015: The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).
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  75. BindingDB Entry 50015279: Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
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  76. BindingDB Entry 50019086: Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
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  77. BindingDB Entry 50021256: Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.
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  78. BindingDB Entry 50019988: Development of potent and selective degraders of PI5P4Kγ.
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