Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease
Cited by (278)
Items 201–278 of 278
- Assessing the Presence of Phosphoinositides on Autophagosomal Membrane in Yeast by Live Cell ImagingJing-Zhen Song, Yi-He Feng, Valentina Sergevnina, Jing Zhu, Hui Li, Zhiping Xie · 2024 · Microorganisms
- Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminusMeredith L. Jenkins, Harish Ranga-Prasad, Matthew AH Parson, Noah J Harris, Manoj Kumar Rathinaswamy, John E. Burke · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Kinase Inhibitors for Targeted Cancer TherapyM. Amin Mir, Devalina Ray, Suman Mazumdar, Bimal Krishna Banik · 2025 · Current Topics in Medicinal Chemistry
- A computational framework for the investigation of phosphoinositide regulationHilaire Yam Fung Cheung, Chukiat Tantiwong, Dipali Kale, Jonathan M. Gibbins, Steve P. Watson, Johan W. M. Heemskerk, Albert Sickmann, Robert Ahrends, Joanne L. Dunster · 2025 · PLoS Computational Biology
- Early phase development of PI3kinase inhibitors for anticancer therapiesCarlo Caputo, Angela Lombardi, Miryam DEL VICARIO, Domenico Cautela, Raffaele Addeo, Federica Melisi, Anna Grimaldi, Alois Nečas, Evžen Amler, Rossella Sperlongano et al. · 2025 · Expert Opinion on Investigational Drugs
- A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolutionSaulė Špokaitė, Yohei Ohashi, Maxime Bourguet, Antoine Nicolas Dessus, Roger L. Williams · 2026 · eLife
- Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic LiabilityYi Hou, Xinqing Zheng, Yiwen Zhang, Hao Shen, Chenxun Kang, Han Qin, Shuyang Cao, Yasheng Zhu, Xing Wang, Chengliang Sun et al. · 2026 · Journal of Medicinal Chemistry
- Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosisP. A. Shantanu, Bishal Rajdev, Syamprasad NP, Jagadeesh Kumar Gangasani, Arijit Mandal, Samir Ranjan Panda, Ramakrishna Sistla, Sai Balaji Andugulapati, Shiv Kumar Sarin, Dinesh Mani Tripathi et al. · 2026 · Frontiers in Pharmacology
- Research progress of small molecule protein kinase inhibitors (SMKIs) in the treatment of colorectal cancer: mechanism, application, and future prospectsLu Liu, 陈颖君, Mingxin Guo, Fan Yun, Xifeng Li, Le Chen, Y M Li, Feng Li · 2026 · Frontiers in Pharmacology
- Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitorTimothy Salita, Yepy H. Rustam, Vinzenz Hofferek, Michael Jackson, Isaac Tollestrup, Jeffrey P. Sheridan, Vern L. Schramm, Gary B. Evans, Gavin E. Reid, Andrew B. Munkacsi · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K)Gregory G. Aldred, Timothy P. C. Rooney, Henriëtte M. G. Willems, Helen K. Boffey, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews · 2023 · RSC Medicinal Chemistry
- Visualizing the dual interaction of calcineurin with PI4KA and FAM126AQingtong Zhou, Xiao Liu, Ming‐Wei Wang · 2024 · Structure
- Orthosteric–allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancerXiong Liang, Lei Tang, Wenfeng Zhao, Rongtao Wang, Cheng Cheng, Daoping Wang, Yechun Xu, Lei Tang, Yanhua Fan · 2025 · Journal of Advanced Research
- Investigating potential molecular mechanisms of serum exosomal miRNAs in colorectal cancer based on bioinformatics analysisHaifeng Wang, Xiliang Chen, Lingling Bao, Xuede Zhang · 2020 · Medicine
- Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPasesBenjamin R. Duewell, Naomi E. Wilson, Gabriela M. Bailey, Sarah E. Peabody, Scott D. Hansen · 2023 · eLife
- Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamicsNicholaus J. Trenton, Robert T. McLaughlin, Satya K. Bellamkonda, David Tsao, Emily Margaret Mace, Jordan Scott Orange, Volker Schweikhard, Michael R. Diehl · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer modelPallavi Mathur, Camilla de Barros Santos, Hugo Lachuer, Bruno Latgé, F. Radvanyi, B. Goud, Kristine Schauer · 2020 · bioRxiv
- Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerizationMichael J. Norris, Monica L. Husby, William Bill Kiosses, Jieyun Yin, Linda J. Rennick, Anja Heiner, Stephanie Harkins, Rudramani Pokhrel, Sharon L. Schendel, Kathryn M. Hastie et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Epinephrine inhibits PI3K alpha via the Hippo kinasesTing-Yu Lin, Shakti Ramsamooj, Katarina M. Liberatore, Louise Lantier, Neil Vasan, Kannan R. Karukurichi, Seo‐Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume IIMichael Schrader, M Islinger (21832286), J Costello (11103897) · 2022 · Frontiers research topics
- Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domainNoah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1Grace L. Waddell, Emma E. Drew, Henry P. Rupp, Scott D. Hansen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPasesDuewell, Benjamin R., Wilson, Naomi E., Bailey, Gabriela M., Peabody, Sarah E., Hansen, Scott D. · 2023
- Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domainNoah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
- Role and Future Directions of PI3K Inhibitors in Cancer Treatment思远 郝 · 2023 · Hans Journal of Medicinal Chemistry
- Reviewer #2 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain2023 · eLife
- Reviewer #1 (Public Review): Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain2023 · eLife
- Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domainNoah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj Kumar Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
- Author Response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domainNoah J Harris, Meredith L. Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew AH Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E. Moeller, Eleanor Sheekey, Scott D. Hansen et al. · 2023 · eLife
- Author response: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain2023 · eLife
- Reconstitution of ORP-mediated lipid exchange process coupled to PI(4)P metabolismNicolas Fuggetta, Nicola Rigolli, Maud Magdeleine, Agnese Seminara, Guillaume Drin · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPasesBenjamin R. Duewell, Naomi E. Wilson, Gabriela M. Bailey, Sarah E. Peabody, Scott D. Hansen · 2024 · eLife
- Enhanced PI3K/Akt Signaling in Response to p85α Loss is Regulated by Endosomal PI3Kα and PI3PNarendra Thapa, Mo Chen, Vincent L. Cryns, Richard Allen Anderson · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosisP. A. Shantanu, Bishal Rajdev, Jagadeesh Kumar Gangasani, Syamprasad NP, Samir Ranjan Panda, Shiv Kumar Sarin, Dinesh Mani Tripathi, Sai Balaji Andugulapati, V.G.M. Naidu · 2024 · Research Square
- eLife Assessment: Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domainAmy Hamilton Andreotti · 2023 · eLife
- Identifying novel heterozygous PI4KA variants in fetal abnormalitiesCheng Chen, Fan Yang, Xinlin Chen, Sheng Zhao · 2025 · BMC Medical Genomics
- PAQR4: From spatial regulation of cell signaling to physiological homeostasis and diseasesZ.-K. Jin, Zhi‐Qiang Ling · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Recombinant Protein Biosensors of Cell Membrane LipidsКольцова Екатерина Михайловна, Nikita Kolchin, E. I. Nikolaeva, Kirill R. Butov · 2025 · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology
- STX-478, RLY-2608, and LOXO-783: third-generation PIK3CA mutant-selective allosteric inhibitorsYi Hou, Kai Yuan, Wenjian Min, Yasheng Zhu, Yang Peng · 2025 · Elsevier eBooks
- Decoding class II PI3K signaling: From membrane identity to human diseaseRoberta Rubino, Gabriele Squillero, Lorenzo Prever, Emanuele Fantastico, Maria Chiara De Santis, Arezou Kahnamouei, Federico Gulluni, Emilio Hirsch · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Bi-allelic variants in the ribosomal protein RPS6KC1 cause a complex neurodevelopmental disorderLaura Planas‐Serra, Maria Esperanza Rodriguez-Ruiz, Eric Nathaniel Anderson, Agustí Rodríguez‐Palmero, Valentina Vélez-Santamaría, Agatha Schlüter, Edgard Verdura, Gorka Gereñu, Andrés Jiménez-Zúñiga, Alejandro Iñáñez et al. · 2025 · The American Journal of Human Genetics
- Additional file 1 of Aqueous extract of Platycodon grandiflorus attenuates lipopolysaccharide-induced apoptosis and inflammatory cell infiltration in mouse lungs by inhibiting PI3K/Akt signalingZhou, Yang, Tianzi Jin, Gao, Mingtong, Zichen Luo, Mutahir, Sadaf, Shi, Chen, Tong Xie, Lin, Lili, Xu, Jianya, Yingzhao Liao et al. · 2023 · Figshare
- A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolutionSaulė Špokaitė, Yohei Ohashi, Maxime Bourguet, Antoine Nicolas Dessus, Roger Lee Williams · 2026 · eLife
- Phosphorylation of the C-terminus of PI4KA inhibits lipid kinase activityAlexandria L Shaw, Sophia Doerr, Hunter G. Nyvall, Meredith L. Jenkins, Sushant Suresh, Calvin K. Yip, Scott D. Hansen, John E. Burke · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolutionSaulė Špokaitė, Yohei Ohashi, Maxime Bourguet, Antoine Nicolas Dessus, Roger Lee Williams · 2026 · eLife
- Identification d'une déficience humaine en SEC14L2 révélant son rôle dans le système immunitaireDébora Jorge Cordeiro · 2020
- Etudes des facteurs cellulaires et lipidiques déterminant la localisation du site d'assemblage et de bourgeonnement du VIH-1Baptiste Gonzales · 2019 · theses.fr (ABES)
- Exploring PI3K signalling dynamics in pancreatic cancerCarmen Fernanda Ramos Delgado · 2020 · theses.fr (ABES)
- Fonctionnement des échangeurs phosphatidylsérine / phosphatidylinositol 4-phosphate à l’interface entre le réticulum endoplasmique et la membrane plasmiqueNicolas-Frédéric Lipp · 2020 · theses.fr (ABES)
- Role of TTC7A in the control of actin dynamics, leukocytes' migration and contribution to pathologyTania Gajardo · 2021 · theses.fr (ABES)
- Genetic, phenotypic and functional characterization of a cohort of patients with EBV-associated T/NK lymphoproliferationsBenjamin Fournier · 2020 · theses.fr (ABES)
- Contrôle de l'oncogenicité de Kras et isoforme beta de PI3K dans la cancérogenèse du pancréasSilvia Arcucci · 2019 · theses.fr (ABES)
- Rôle de la phosphoinositide 3-kinase de classe II beta dans la dysfonction endothéliale lors d'un accident vasculaire cérébral ischémiqueTyphaine Anquetil · 2020 · theses.fr (ABES)
- Role of lysosome positioning in bladder cancer progressionPallavi Mathur · 2022 · theses.fr (ABES)
- Study of septin 9 in the cell polarity and development of cholangiocarcinomaTing Cai · 2022 · theses.fr (ABES)
- Actin re-organization and lipid dynamics modulated by myosin 1bGwendal Guérin · 2024
- Compounds mimicking the Michaelis-Menten transition state of the phosphatidylinositol 4-kinaseHubert Hřebabecký, Martin Klíma, Milan Dejmek, Pawel Krupa, Miguel Riopedre-Fernández, Eva Dávidová, Jakub Benýšek, Hector Martinez‐Seara, Bartosz Różycki, Evžen Bouřa et al. · 2026 · Bioorganic & Medicinal Chemistry
- A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networksAlicia Llorente Lope, Gurpreet K. Arora, Ryan M. Loughran, Rabi Murad, Svetlana Maurya, Sophia Crabtree, Benji Portillo, Pratima Chapagain, Hundaol Huluka, Scott J. Eron et al. · 2026 · Journal of Biological Chemistry
- Probing Allosteric Kinase Modulators as Next Game-Changers in Fighting NeurodegenerationElena Roggiolani, Michela Rosini, Anna Minarini, Filippo Basagni · 2026 · Journal of Medicinal Chemistry
- The antitumor promise of furo[2,3- d ]pyrimidine: a 2016–2025 reviewMai A. Mansour, Haya A Elshafei, Alaa S. Sayed, Aya A. Ashour, Nadia E. Hussein, Marwan M. Abdel Karim, Fares M. Kamel, Nada T. Elsayed, Mahmoud R. Ahmed, Mohamed T. Seleem et al. · 2026 · RSC Advances
- The crosslink between autophagy and ferroptosis in polycystic ovary syndrome: from synergistic pathogenesis to targeted therapyXujin Wu, Jiarui Li, Xuesong Zhang, Huili Huang, Tianjiao Li, Mingyue Kong, Ziqi Dai, Yihan Yang, Xin Chen · 2026 · Journal of Ovarian Research
- ARMH3 acts as a central scaffold at the Golgi/TGN through interactions with Arl5, GBF1, and PI4KBMackenzie K. Scott, Giselle CT Klynsoon, Emma E. Walsh, Sushant Suresh, Hunter G. Nyvall, John E. Burke · 2026 · Journal of Biological Chemistry
- Recent advances in 1,3,5-triazine-based PI3K inhibitors for cancer therapy: a comprehensive reviewUtkarsha Kulkarni, Adarsh Yadav, Princy Desai, Clement Thangtinkhum, Drashti Shah, Afzal Nagani, Ashish Shah, Mehul Patel, Umang Shah, Swayamprakash Patel et al. · 2026 · Future Medicinal Chemistry
- PI4K and PIPK families in breast cancer: subtype-specific oncogenic mechanisms and precision therapeutic strategiesShanmei Du · 2026 · Molecular Biology Reports
- Reconstitution of Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputsSophia Doerr, Andres Olavarrieta Colasurdo, Scott D. Hansen · 2026 · Nature Communications
- A Rac-PI3Kβ feedback loop drives GPVI-dependent platelet activationTom N. Durrant, James L. Hutchinson, Carl May, Justin S. Trory, Samantha Moore, Ingeborg Hers · 2026 · iScience
- PLCd4 signaling-mediated PI4P synthesis drives macrophage NLRP3 inflammasome activation to promote heat stroke-induced tissue injuryRiqing Wei, Wenqian Zheng, Chenxin Liu, Dinghao Dang, Xinyu Deng, Xiaoting Hu, Hui Liang, Xi Luo, Jiayi Tang, Wei Zhu et al. · 2026 · Cell Reports
- Activation of the PI3K/AKT/mTOR signaling pathway in bladder cancer pathogenesis and its therapeutic significanceDereje E. Bogale · 2026 · Cancer Treatment and Research Communications
- Broad-spectrum host-targeting antivirals for rhinovirus infections: mechanisms and future perspectivesWanru Shang, Hongbin Luo, Siqi Li, Shichao Yu, Xinyu Wang, Dongye Fu, Lijun Wang, Fanzheng Meng, Man Gao · 2026 · Frontiers in Immunology
- Shenshuai Yingyang Jiaonang attenuates CKD-induced muscle atrophy: a role for Faecalibacterium prausnitzii and the EGFR/PI3K/AKT signaling axisZhuoen He, Jinyue He, Chi Zhang, Hao Wang, Fujing Wang, Tingting Pei, Rong Hu, Zhiqiang Xian, Junfeng Li, Dinghui Liu et al. · 2026 · Phytomedicine
- Functional role of the second messengers PtdIns(3,4,5)P 3 and PtdIns(3,4)P 2 in carcinogenesisNina Nelson, Manfred Jücker · 2026 · Biological Chemistry
- BindingDB Entry 50019333: The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50016594: Kinase Inhibitors as Underexplored Antiviral Agents.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50020015: The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).BindingDB · 2024 · UC San Diego
- BindingDB Entry 50015279: Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50019086: Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50021256: Advancements in dual-target inhibitors of PI3K for tumor therapy: Clinical progress, development strategies, prospects.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50019988: Development of potent and selective degraders of PI5P4Kγ.BindingDB · 2024 · UC San Diego