SLC19A1 is an importer of the immunotransmitter cGAMP.

Ritchie, Christopher, Cordova, Anthony F., Hess, Gaelen T., Bassik, Michael C., Li, Lingyin·2019·Molecular Cell

DOI 10.1016/j.molcel.2019.05.006

Cited by (335)

Items 101–200 of 335

Structure-based mechanisms of 2′3′-cGAMP intercellular transport in the cGAS–STING immune pathway
Wei Xie, Dinshaw J. Patel · 2023 · Trends in Immunology
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases
Mingqi Dong, Katherine A. Fitzgerald · 2024 · Nature Immunology
Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathway
Yiyun Michelle Fan, Yizhuo Lyanne Zhang, Honglin Luo, Yasir Mohamud · 2022 · Reviews in Medical Virology
Dysregulation of the cGAS-STING Pathway in Monogenic Autoinflammation and Lupus
Holly Wobma, Daniel Sanghoon Shin, Janet S. Chou, Fatma Dedeoğlu · 2022 · Frontiers in Immunology
Interplay between RNA viruses and cGAS/STING axis in innate immunity
Lucia Amurri, Branka Horvat, Mathieu Iampietro · 2023 · Frontiers in Cellular and Infection Microbiology
Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint
Rachel E. Mardjuki, Songnan Wang, Jacqueline A. Carozza, Bahar Zirak, Vishvak Subramanyam, Gita C. Abhiraman, Xuchao Lyu, Hani Goodarzi, Lingyin Li · 2024 · Cell Reports
CRISPR screen in mechanism and target discovery for cancer immunotherapy
Dan Liu, Xuan Zhao, Anqun Tang, Xiyue Xu, Shuci Liu, Li Zha, Wen Ma, Junnian Zheng, Ming Shi · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Harnessing the cGAS-STING pathway to potentiate radiation therapy: current approaches and future directions
Nicholas W. Colangelo, Naamit Kurshan Gerber, Ralph E. Vatner, Benjamin Thomas Cooper · 2024 · Frontiers in Pharmacology
Vaccinia Virus Activation and Antagonism of Cytosolic DNA Sensing
Misbah El-Jesr, Muad Teir, Carlos Maluquer de Motes · 2020 · Frontiers in Immunology
A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells
Alex J. Pollock, Shivam A. Zaver, Joshua John Woodward · 2020 · Nature Communications
Discovery of key genes as novel biomarkers specifically associated with HPV-negative cervical cancer
Yi Liu, Yichi Xu, Wenxiao Jiang, Huihui Ji, Zhiwei Peter Wang, Xueqiong Zhu · 2021 · Molecular Therapy — Methods & Clinical Development
Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes
Dieter Kabelitz, Michał Konrad Zarobkiewicz, Michelle Heib, Ruben Serrano, Monika Kunz, Guranda Chitadze, Dieter Adam, Christian Peters · 2022 · Scientific Reports
The clinical and molecular significance associated with STING signaling in breast cancer
Eileen E. Parkes, Matthew P. Humphries, Elaine S. Gilmore, Fatima Abdullahi Sidi, Victoria Bingham, Su Myat Phyu, Stephanie G. Craig, Catherine Graham, Joseph J. Miller, Daryl Griffin et al. · 2021 · npj Breast Cancer
Defining Immunogenic and Radioimmunogenic Tumors
Terry R. Medler, Tiffany C. Blair, Marka R. Crittenden, Michael J. Gough · 2021 · Frontiers in Oncology
STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33–driven type 2 immunopathology
Li She, Gema D. Barrera, Liping Yan, Hamad H. Alanazi, Edward G. Brooks, Peter H. Dube, Yilun Sun, Hong Zan, Daniel Phillip Chupp, Nu Zhang et al. · 2021 · JCI Insight
Targeting the loss of cGAS / STING signaling in cancer
Nobunari Sasaki, Mizuki Homme, Shunsuke Kitajima · 2023 · Cancer Science
cGAS-like receptor-mediated immunity: the insect perspective
Hua Cai, Carine Meignin, Jean‐Luc Imler · 2022 · Current Opinion in Immunology
Molecular mechanism of substrate recognition by folate transporter SLC19A1
Dang, Yu, Zhou, Dong, Du, Xiaojuan, Zhao, Hongtu, Lee, Chia-Hsueh, Yang, Jing, Wang, Yijie, Qin, Changdong, Guo, Zhenxi, Zhang, Zhe · 2022 · Cell Discovery
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu · 2025 · 癌症：英文版
Methotrexate Pharmacogenetics in the Treatment of Rheumatoid Arthritis
Biljana Jekić, Nela Maksimović, Tatjana Damnjanović · 2019 · Pharmacogenomics
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production
Andrew D. Hildreth, Eddie T. Padilla, Meha Gupta, Yung Yu Wong, Ryan Sun, Akshara R. Legala, Timothy Edward O’Sullivan · 2023 · Nature Metabolism
Intrinsic strategies for the evasion of cGAS-STING signaling-mediated immune surveillance in human cancer: How therapy can overcome them
Shan-Shan Zou, Yuan Qiao, Shan Zhu, Bao Gao, Ning Yang, Yong-Jun Liu, Jingtao Chen · 2021 · Pharmacological Research
Charting a killer course to the solid tumor: strategies to recruit and activate NK cells in the tumor microenvironment
Ana L. Portillo, Jonathan K. Monteiro, Eduardo A. Peña Rojas, Tyrah M. Ritchie, Amy E. Gillgrass, Ali A. Ashkar · 2023 · Frontiers in Immunology
The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy
Ana Rita Salgado Ribeiro, Theresa Neuper, Jutta Horejs‐Hoeck · 2024 · International Journal of Nanomedicine
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP
Xiaobo Li, Yuanyuan Zhu, Xiao Zhang, Xiang An, Mingjiao Weng, Jiaqi Shi, Song Wang, Caiqi Liu, Shengnan Luo, Tongsen Zheng · 2021 · Journal of Clinical Investigation
Tumor immunology CRISPR screening: present, past, and future
Matthew B. Dong, Kaiyuan Tang, Xiaoyu Zhou, Jingjia J. Zhou, Sidi Chen · 2021 · Trends in cancer
Regulation of cGAS Activity and Downstream Signaling
Bhagwati Joshi, Jagdish Chandra Joshi, Dolly Mehta · 2022 · Cells
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP
Xiaobo Li, Yuanyuan Zhu, Xiao Zhang, Xiang An, Mingjiao Weng, Jiaqi Shi, Song Wang, Caiqi Liu, Shengnan Luo, Tongsen Zheng · 2022 · DOAJ (DOAJ: Directory of Open Access Journals)
The pleiotropic roles of cGAS–STING signaling in the tumor microenvironment
Jun Li, Samuel F. W. Bakhoum · 2022 · Journal of Molecular Cell Biology
STING signaling in inflammaging: a new target against musculoskeletal diseases
Chenyu Song, Zhuoyi Hu, Dingjun Xu, Huihui Bian, Juan Lv, Zhu Xuanxuan, Qiang Zhang, Li Su, Heng Yin, Tong Lu et al. · 2023 · Frontiers in Immunology
cGAS‐STING signaling in cancer: Regulation and therapeutic targeting
Xinzou Fan, Xiaoshuang Song, Wenjing Chen, Hantian Liang, Hiroko Nakatsukasa, Dunfang Zhang · 2023 · MedComm – Oncology
Advances in cGAS-STING Signaling Pathway and Diseases
Yuting Yang, Yiming Huang, Zhenguo Zeng · 2022 · Frontiers in Cell and Developmental Biology
Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export
Omkar Dilip Shinde, Joshua A. Boyer, Stephanie Cambier, Jordyn J. VanPortfliet, Xuewu Sui, Gaya Prasad Yadav, Elizabeth G. Viverette, Mario Juan Borgnia, Andrew Phillip West, Qi Zhang et al. · 2025 · Immunity
Critical DNA damaging pathways in tumorigenesis
Jake A. Kloeber, Zhenkun Lou · 2021 · Seminars in Cancer Biology
The transcriptome profile of human trisomy 21 blood cells
Francesca Antonaros, Rossella Zenatelli, Giulia Guerri, Matteo Bertelli, Chiara Locatelli, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Human Genomics
Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes
Elisha Segrist, Mark Dittmar, Beth Gold, Sara R. Cherry · 2021 · Cell Reports
Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells
Ruben Serrano, Marcus Lettau, Michał Konrad Zarobkiewicz, Daniela Wesch, Christian Peters, Dieter Kabelitz · 2022 · OncoImmunology
Regulation of cGAS-STING pathway - Implications for systemic lupus erythematosus
Audrey M. Hagiwara, Richard E. Moore, Daniel J. Wallace, MARIKO L. ISHIMORI, Caroline Anne Jefferies · 2021 · Rheumatology and Immunology Research
Crosstalk between cGAS-STING pathway and autophagy in cancer immunity
Qijun Lu, Yukun Chen, Jianwen Li, Feng Zhu, Zhan Zheng · 2023 · Frontiers in Immunology
Second messenger 2′3′-cyclic GMP–AMP (2′3′-cGAMP): Synthesis, transmission, and degradation
Mincun Su, Jianpei Zheng, Linchuan Gan, Yuxiang Zhao, Yajuan Fu, Qi Chen · 2022 · Biochemical Pharmacology
STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
Luis Eduardo Alves Damasceno, Guilherme Cesar Martelossi Cebinelli, Mariane Font Fernandes, Daniele C. Nascimento, Gabriel Azevedo Públio, Marco Aurélio Ramirez Vinolo, Sergio Costa Oliveira, Tim D. Sparwasser, Thiago M. Cunha, Fernando Q. Cunha et al. · 2022 · Cell Reports
DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
Otto P.G. Wheeler, Leonie Unterholzner · 2023 · Essays in Biochemistry
STING in cancer immunoediting: Modeling tumor-immune dynamics throughout cancer development
Xiao Zhang, Yan Chen, Xi Liu, Genbang Li, Shuo Zhang, Qi Zhang, Zihan Cui, Minglu Qin, Hans‐Uwe Simon, Janoš Terzić et al. · 2025 · Cancer Letters
Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2′3′-Cyclic GMP–AMP and Cisplatin under Steady State and Inflammation
Xia Chen, Li Wang, Limin Cao, Tiantian Li, Zhihong Li, Yumeng Sun, Jinqiu Ding, Chun Zhou, Yadong Xie, Nan Yue et al. · 2021 · The Journal of Immunology
Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production
Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, Timothy Edward O’Sullivan · 2023 · Cell Reports
Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
Denis Chang, Aaron T. Whiteley, Katlynn Bugda Gwilt, Wayne I. Lencer, John J. Mekalanos, Jay R. Thiagarajah · 2020 · Proceedings of the National Academy of Sciences
The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges
Zheqi Zhou, Sanling Huang, Fangying Fan, Yan Xu, Casey Moore, Sirui Li, Chuanhui Han · 2024 · Medical Review
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
Ruirui Yang, Wang Bei, Zhaoming Su, Ying Song, Yingying Zhang, Yadan Liu, Yinghui Zhang, Changyu He, Yang Xi, Feisheng Zhong et al. · 2025 · Science Translational Medicine
Cysteine allostery and autoinhibition govern human STING oligomer functionality
Rebecca Chan, Xujun Cao, Sabrina L. Ergun, Evert Njomen, Stephen R. Lynch, Christopher Ritchie, Benjamin F. Cravatt, Lingyin Li · 2025 · Nature Chemical Biology
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants
Zhenghua Wang, Can-Can Zhao, Chuanlin Wang, Hang Zhang, Dejun Ma, Qiangzhe Zhang, Xin Wen, Luyuan Li, Zhen Xi · 2020 · Bioorganic & Medicinal Chemistry
cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders
Fengjuan Li, Ningqun Wang, Yangmin Zheng, Yumin Luo, Yongbo Zhang · 2021 · Aging and Disease
Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act
Xujun Cao, Anthony F. Cordova, Lingyin Li · 2021 · Chemical Reviews
Attenuation of cGAS/STING activity during mitosis
Brittany L. Uhlorn, Eduardo R. Gamez, Shuaizhi Li, Samuel K. Campos · 2020 · Life Science Alliance
cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette
Hua Cai, Jean‐Luc Imler · 2021 · Faculty Reviews
Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication
Uday Tak, Kate Schinkel, Peace Walth, Jian Wei Tay, Erik W. Hartwick, Aaron T. Whiteley · 2026 · Cell Host & Microbe
Bridging innate and adaptive tumor immunity: cGAS–STING pathway activation to potentiate immune checkpoint blockade
Zhuo Ya Li, Wei Zheng, Yisi Liu, Rong Cao, Jing Wei, Haiqing Jia · 2025 · Journal of Experimental & Clinical Cancer Research
Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples
Rachel E. Mardjuki, Jacqueline A. Carozza, Lingyin Li · 2020 · Journal of Biological Chemistry
Cytosolic detection of phagosomal bacteria—Mechanisms underlying PAMP exodus from the phagosome into the cytosol
Stephanie A. Ragland, Jonathan C. Kagan · 2021 · Molecular Microbiology
The role of STING signaling in central nervous system infection and neuroinflammatory disease
Lauren E. Fritsch, Colin Kelly, Alicia M. Pickrell · 2023 · WIREs Mechanisms of Disease
Targeting cGAS/STING signaling-mediated myeloid immune cell dysfunction in TIME
Vijay Kumar, Caitlin Bauer, John H. Stewart · 2023 · Journal of Biomedical Science
Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA
Yi Ye, Guihui Qin, Hongmei Yang, Jia Hao, Qibing Zeng, Dejin Zheng, Sen Ye, Zhiming Zhang, Tzu‐Ming Liu, Kathy Qian Luo et al. · 2024 · Advanced Science
HSV-1 employs UL56 to antagonize expression and function of cGAMP channels
Henry T.W. Blest, Alexander Redmond, Jed Avissar, Jake Barker, Anne Bridgeman, Gerissa Fowler, Lise Chauveau, Jonny Hertzog, Iolanda Vendrell, Roman Fischer et al. · 2024 · Cell Reports
Intercellular transmission of cGAS-STING signaling in cancer
Qirou Wu, Xiaohong Leng, Pinglong Xu · 2023 · Cancer Biology and Medicine
Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation
Jie Su, Pierre Coleman, Angeliki Ntorla, Rhys Anderson, Michael J. Shattock, Joseph Robert Burgoyne · 2023 · Circulation
cGAS-like receptors drive a systemic STING-dependent host response in Drosophila
Xianlong Ai, Huimin Deng, Xiaoyan Li, Ziming Wei, Yuqiang Chen, Ting Yin, Junhui Zhang, Jingxian Huang, Haoming Li, Xiaoqing Lin et al. · 2024 · Cell Reports
Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target
Nádia Duarte, Abdul Muktadir Shafi, Carlos Penha‐Gonçalves, Teresa Faria Pais · 2023 · Frontiers in Cell and Developmental Biology
Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity
Xuan Wu, Lantian Zhou, Chen Ye, Zhenzhong Zha, Chuchu Li, Chao Feng, Yue Zhang, Qian Jin, Jianyi Pan · 2023 · Cell Reports
A homozygous deletion in the SLC19A1 gene as a cause of folate-dependent recurrent megaloblastic anemia
Michael Svatoň, Karolina Škvárová Kramarzová, Veronika Kanderová, Andrea Mančíková, Petr Smíšek, Pavel Ješina, Jakub Krijt, Blanka Stibůrková, Robert Dobrovolný, Jitka Sokolová et al. · 2020 · Blood
Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants
Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto, Yasuo Yoshioka · 2022 · npj Vaccines
Exogenous DNA enhances DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway
Stephen L. Wang, Yongzhong Wu, Mariam M. Konaté, Jiamo Lu, David J. Mallick, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Iris M. Dahan, Agnes N. Juhasz et al. · 2023 · Free Radical Biology and Medicine
Tumor immune microenvironment-modulated nanostrategy for the treatment of lung cancer metastasis
Lingling Zhu, Juan Wu, Honglin Gao, Ting I. Wang, Guixiu Xiao, Chenggong Hu, Qing Lin, Qinghua Zhou · 2023 · Chinese Medical Journal
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression
Xiaoyu Ma, Man-man Chen, Linghua Meng · 2024 · Acta Pharmacologica Sinica
Stimulating STING for cancer therapy: Taking the extracellular route
Lingyin Li · 2024 · Cell chemical biology
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia
Xiangyu Ge, Xingfei Zhu, Wei Liu, Mingsen Li, Zhaotian Zhang, Ming Zou, Mi Deng, Haifeng Cui, Ziqing Chen, Li Wang et al. · 2025 · Journal of Neuroinflammation
Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing
Eloi Rémi Verrier, Christelle Langevin · 2021 · Frontiers in Immunology
Chemical evolution of cyclic dinucleotides: Perspective of the analogs and their preparation
Zhenghua Wang, Zhen Xi · 2021 · Tetrahedron
Polyvalent design in the cGAS-STING pathway
Zachary T. Bennett, Suxin Li, Baran D. Sumer, Jinming Gao · 2021 · Seminars in Immunology
SARS‐CoV‐2, HIV, and HPV: Convergent evolution of selective regulation of cGAS–STING signaling
Si Shen, Yajuan Rui, Yanpu Wang, Jiaming Su, Xiao‐Fang Yu · 2022 · Journal of Medical Virology
STING Targeting in Lung Diseases
Dorian de Moura Rodrigues, Norinne Lacerda‐Queiroz, Isabelle Couillin, Nicolas Riteau · 2022 · Cells
The Role of the Toll-like Receptor 2 and the cGAS-STING Pathways in Breast Cancer: Friends or Foes?
Chiara Cossu, Antonino Di Lorenzo, Irene Fiorilla, Alberto Maria Todesco, Valentina Audrito, Laura Conti · 2023 · International Journal of Molecular Sciences
Enhancing nano-immunotherapy of cancer through cGAS–STING pathway modulation
Gaohong Fu, Yanan Zhao, Chengqiong Mao, Yang Liu · 2025 · Biomaterials Science
Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels
Limin Cao, Wang Li, Zhihong Li, Xia Wei, Jinqiu Ding, Chun Zhou, Xia Chen, Zhicheng Huang, Zhugui Shao, Junchen Shen et al. · 2025 · Science Immunology
Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment
Veysel Gök, Şerife Erdem, Yeşim Haliloğlu, Atıl Bişgin, Serkan Belkaya, Kemal Erdem Başaran, Mehmed Fatih Canatan, Alper Özcan, Ebru Arik Yilmaz, Can Acıpayam et al. · 2022 · Genes and Immunity
Unveiling tumor immune evasion mechanisms: abnormal expression of transporters on immune cells in the tumor microenvironment
Lu Chen, Yuchen Wang, Qingqing Hu, Yuxi Liu, Xuchen Qi, Zhihua Tang, Haihong Hu, Nengming Lin, Su Zeng, Lushan Yu · 2023 · Frontiers in Immunology
cGLRs Join Their Cousins of Pattern Recognition Receptor Family to Regulate Immune Homeostasis
Vijay Kumar, John H. Stewart · 2024 · International Journal of Molecular Sciences
Recent advances in the structure, function and regulation of the volume‐regulated anion channels and their role in immunity
Sergei Yanushkevich, Aleksandra Zieminska, Joshua Gonzalez, Francisca Añazco, Richard S. Song, Alejandra Arias‐Cavieres, Sara T. Granados, Junyi Zou, Yan Rao, Axel R. Concepcion · 2024 · The Journal of Physiology
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
Mark Jelcic, Ke Wang, King Lam Hui, Xiao-Chuan Cai, Balázs Enyedi, Minkui Luo, Philipp Niethammer · 2020 · Cell chemical biology
ATP-Binding Cassette and Solute Carrier Transporters: Understanding Their Mechanisms and Drug Modulation Through Structural and Modeling Approaches
Ahmad Elbahnsi, Bálint Dudás, Isabelle Callebaut, Alexandre Hinzpeter, Maria A. Miteva · 2024 · Pharmaceuticals
A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA
Steve Smarduch, Sergio David Moreno-Velásquez, Doroteja Ilic, Shashank Dadsena, Ryan Morant, Anja Ciprinidis, Gislene Pereira, Marco Binder, Ana J. García‐Sáez, Sergio P. Acebrón · 2025 · The EMBO Journal
The cGAS-STING pathway: Mechanism and medical implications
Alexander Hooftman, Alexander Keller, Andrea Ablasser · 2026 · Cell
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
Gökçe Gürler, Nevin Belder, Mustafa Çağlar Beker, Melike Sever, Gӧkhan Uruk, Ertuğrul Kılıç, Müge Yemişçi · 2023 · Fluids and Barriers of the CNS
Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists
Wei Xie, Lodoe Lama, Xuejing Yang, Vitaly Kuryavyi, Shibani Bhattacharya, Ilona Nudelman, Guangli Yang, Ouathek Ouerfelli, Joseph Fraser Glickman, Roger A. Jones et al. · 2023 · Cell chemical biology
Stimulator of Interferon Genes (STING) Triggers Adipocyte Autophagy
Kornél Z. Varga, Katalin Gyurina, Ádám Radványi, Tibor Pál, László Sasi-Szabó, Haidong Yu, Enikő Felszeghy, Tamás Szabó, Tamás Rőszer · 2023 · Cells
CRISPR/Cas9 screening: unraveling cancer immunotherapy’s ‘Rosetta Stone’
Baoxiang Chen, Yanrong Deng, Xianghai Ren, Jianhong Zhao, Congqing Jiang · 2024 · Trends in Molecular Medicine
ATP-elicited Cation Fluxes Promote Volume-regulated Anion Channel LRRC8/VRAC Transport cGAMP for Antitumor Immunity
Li Wang, Limin Cao, Zhihong Li, Zhugui Shao, Xia Chen, Zhicheng Huang, Xiaoxiao He, Junke Zheng, L.-Z. Liu, Xin‐Ming Jia et al. · 2024 · The Journal of Immunology
Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
Xiaohui Zhao, Xinglin Yang, Howard C. Hang · 2022 · Biochemistry
Manipulation of the nucleotide pool in human, bacterial and plant immunity
Dina Hochhauser, Rotem Sorek · 2025 · Nature reviews. Immunology
Organelle-specific signaling of cGAS–STING
Shengduo Liu, Ailian Wang, Chen Chen, Pinglong Xu · 2025 · Trends in Cell Biology
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
Christopher Ritchie, Lingyin Li · 2024 · Molecular Cell
cGAMP as an Adjuvant in Antiviral Vaccines and Cancer Immunotherapy
Christopher Ritchie, Lingyin Li · 2020 · Biochemistry