The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
R-Loop Mediated trans Action of the APOLO Long Noncoding RNA
Open accessAbstract
In eukaryotes, three-dimensional genome organization is critical for transcriptional regulation of gene expression. Long noncoding RNAs (lncRNAs) can modulate chromatin conformation of spatially related genomic locations within the nucleus. Here, we show that the lncRNA APOLO (AUXIN-REGULATED PROMOTER LOOP) recognizes multiple distant independent loci in the Arabidopsis thaliana genome. We found that APOLO targets are not spatially associated in the nucleus and that APOLO recognizes its targets by short sequence complementarity and the formation of DNA-RNA duplexes (R-loops). The invasion of APOLO to the target DNA decoys the plant Polycomb Repressive Complex 1 component LHP1, modulating local chromatin 3D conformation. APOLO lncRNA coordinates the expression of distal unrelated auxin-responsive genes during lateral root development in Arabidopsis. Hence, R-loop formation and chromatin protein decoy mediate trans action of lncRNAs on distant loci. VIDEO ABSTRACT.
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Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
Long non-coding RNAs: definitions, functions, challenges and recommendations
Mattick, J. S., Amaral, P. P., Carninci, P., Carpenter, S., Chang, H. Y., Chen, L.-L., Chen, R., Dean, C., Dinger, M. E., Fitzgerald, K. A., et al. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00566-8 · Cited by 2,356
Integrated lncRNA function upon genomic and epigenomic regulation
Herman, A. B., Tsitsipatis, D., & Gorospe, M. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.05.027 · Cited by 747
Yadav, A., Mathan, J., Dubey, A. K., & Singh, A. (2024) · Non-Coding RNA · doi:10.3390/ncrna10010013 · Cited by 83
How Stress Facilitates Phenotypic Innovation Through Epigenetic Diversity
Srikant, T., & Drost, H.-G. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2020.606800 · Cited by 67
Metadata
- Authors
- Ariel, F., Lucero, L., Christ, A., Mammarella, M. F., Jegu, T., Veluchamy, A., Mariappan, K., Latrasse, D., Blein, T., Liu, C., Benhamed, M., & Crespi, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 77
- Issue
- 5
- Pages
- 1055-1065.e4
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2999589659
- Cited by
- 287
- References
- 56
- FWCI
- 25.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ariel, F., Lucero, L., Christ, A., Mammarella, M. F., Jegu, T., Veluchamy, A., Mariappan, K., Latrasse, D., Blein, T., Liu, C., Benhamed, M., & Crespi, M. (2020). R-Loop Mediated trans Action of the APOLO Long Noncoding RNA. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.12.015
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