A Mechanism for microRNA Arm Switching Regulated by Uridylation
Published version of a preprint
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TUT4/TUT7 uridylate the 3′ end of miR-324-3p, which changes the site of Dicer processing to generate a shorter miR-324 duplex that undergoes reversed strand selection, stabilizing the miR-324-3p strand instead of the typically more abundant miR-324-5p strand.
“TUT4/TUT7 uridylate the 3′ end of miR‐324‐3p, which changes the site of Dicer processing to generate a shorter miR‐324 duplex that undergoes reversed strand selection, stabilizing the miR‐324‐3p strand instead of the typically more abundant miR‐324‐5p strand (Figure 4c; Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
TUT4/TUT7 affect strand selection of human miR-324.
“have recently been shown to affect strand selection of human miR‐324 (Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
TUT4/TUT7 expression levels appear to be regulated in developmental and tissue-specific fashions.
“Interestingly, TUT4/TUT7 expression levels appear to be regulated in developmental and tissue‐specific fashions, suggesting that regulation of TUT4/TUT7 activity can dictate strand selection of miR‐324 in humans, resulting in arm switching across tissues (Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
Regulation of TUT4/TUT7 activity can dictate strand selection of miR-324 in humans, resulting in arm switching across tissues.
“suggesting that regulation of TUT4/TUT7 activity can dictate strand selection of miR‐324 in humans, resulting in arm switching across tissues (Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
TUT-4/7 are up-regulated in glioblastoma and miR-324 arm switching appears to correlate with a poor prognosis.
“Intriguingly, TUT‐4/7 are up‐regulated in glioblastoma and miR‐324 arm switching appears to correlate with a poor prognosis (Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
A recent study provides a direct molecular mechanism for miR-324 arm switching through uridylation and subsequent alternative Dicer processing.
“Notable is a recent study providing a direct molecular mechanism for miR‐324 arm switching through uridylation and subsequent alternative Dicer processing (Kim et al., 2020).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
Uridylation of miR-324 by TUT-4/7 directly influences the arm switching of miR-324.
“Recently, uridylation of miR‐324 by TUT‐4/7 was shown to directly influence the arm switching of miR‐324 (Kim et al., 2020, Figure 4c, Table 1).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Moore, M. J., Scheel, T. K. H., Luna, J. M., Park, C. Y., Fak, J. J., Nishiuchi, E., Rice, C. M., & Darnell, R. B. (2015) · Nature Communications · doi:10.1038/ncomms9864 · Cited by 326 · see citing works
Skalsky, R. L., & Cullen, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024248 · Cited by 170 · see citing works
Small-RNA asymmetry is directly driven by mammalian Argonautes
Suzuki, H. I., Katsura, A., Yasuda, T., Ueno, T., Mano, H., Sugimoto, K., & Miyazono, K. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3050 · Cited by 108 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Martin, M. (2011). Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet.journal 17, 10-12.
- Xiao, W.L., Zeng, H.L., Wang, Y.Z., Gou, Q., Zhou, Z.J., Xu, R.D., Li, W.K., Zhuang, W.X., and Chen, X.M. (2017). Up-regulation of miR-324 suppresses cell apoptosis by targeting DUSP1 in hepatocellular carcinoma. International Journal of Clinical and Experimental Pathology 10, 1243-1252.
Cited by
Sorted by citations
microRNA strand selection: Unwinding the rules
Medley, J. C., Panzade, G., & Zinovyeva, A. Y. (2021) · WIREs RNA · doi:10.1002/wrna.1627 · Cited by 225 · see citing works
A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing
Yu, S., & Kim, V. N. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0246-8 · Cited by 142 · see citing works
Self-citationmiR-33b-3p Acts as a Tumor Suppressor by Targeting DOCK4 in Prostate Cancer
Mei, Y., Li, K., Zhang, Z., Li, M., Yang, H., Wang, H., Huang, X., Li, X., Shi, S., & Yang, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.740452 · Cited by 10 · see citing works
“Recent study indicates that high level of the terminal uridylyl transferases TUT4 and TUT7 leads to selection of the 3p strand instead of the 5p strand of miR-324 (28).”
BackgroundOliveira, A. C. D., Bovolenta, L. A., Figueiredo, L., Ribeiro, A. D. O., Pereira, B. J. A., de Almeida, T. R. A., Campos, V. F., Patton, J. G., & Pinhal, D. (2024) · Evolutionary Bioinformatics · doi:10.1177/11769343241263230 · Cited by 2 · see citing works
Human brain microRNAs exhibit cell-type specificity and age dependence
Dubnov, S., Laski, L., Zchut, I., Avidan, O., Bennett, E. R., Greenberg, D. S., Turjeman, A., Nitzan, M., Paldor, I., & Soreq, H. (2026) · doi:10.64898/2026.01.04.697535
- Authors
- Kim, H., Kim, J., Yu, S., Lee, Y.-Y., Park, J., Choi, R. J., Yoon, S.-J., Kang, S.-G., & Kim, V. N.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 78
- Issue
- 6
- Pages
- 1224-1236.e5
- ISSN
- 1097-2765
- Cited by
- 90
- References
- 4
- Language
- en
- Licence
- Funders
- Institute for Basic Science
- Ministry of Science and ICT of Korea (IBS-R008-D1, BK21)
- Ministry of Education of Korea
- NRF
- Korean government (NRF-2015-Global Ph.D. Fellowship Program, NRF-2018-Global Ph.D. Fellowship Program)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
