Cited by 142RNA Research and SplicingRNA modifications and cancerRNA regulation and disease

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

Yu, Sha, Kim, V. Narry·2020·Nature Reviews Molecular Cell Biology

Abstract

RNA tailing, or the addition of non-templated nucleotides to the 3' end of RNA, is the most frequent and conserved type of RNA modification. The addition of tails and their composition reflect RNA maturation stages and have important roles in determining the fate of the modified RNAs. Apart from canonical poly(A) polymerases, which add poly(A) tails to mRNAs in a transcription-coupled manner, a family of terminal nucleotidyltransferases (TENTs), including terminal uridylyltransferases (TUTs), modify RNAs post-transcriptionally to control RNA stability and activity. The human genome encodes 11 different TENTs with distinct substrate specificity, intracellular localization and tissue distribution. In this Review, we discuss recent advances in our understanding of non-canonical RNA tails, with a focus on the functions of human TENTs, which include uridylation, mixed tailing and post-transcriptional polyadenylation of mRNAs, microRNAs and other types of non-coding RNA.

Integrity signals

Registry

Crossref · 10.1038/s41580-020-0246-8

Cites

201 of 201 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A poly(A) tail of optimal length can improve translation efficiency and mRNA stability.

    “A poly(A) tail of optimal length can improve translation efficiency and mRNA stability.150,151”

    From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [151]

Cites

Flagged first, then by citations

2 of the 203 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Yu, S., & Kim, V. N.
Affiliations
  • Institute for Basic Science (KR)
  • Seoul National University (KR)
Corresponding author
Kim, V. Narry
Venue
Nature Reviews Molecular Cell Biology
Published
2020-06-01
Volume
21
Issue
9
Pages
542-556
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W3032039819
Cited by
142
References
203
Citations by year
2026: 23 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 25 · 2021: 24 · 2020: 3
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
uridylation, RNA stability, microRNA, non-coding RNA, mRNA maturation, poly(A) polymerase
MeSH terms
Animals, Gene Expression Regulation, Humans, Nucleotidyltransferases, RNA, RNA Processing, Post-Transcriptional, RNA, Messenger, 3' Untranslated Regions, RNA Stability, Polyadenylation, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review