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Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

Kim, Sung-Hoon, Choi, Jung-Hyun, Wang, Peng, Go, Christopher D., Hesketh, Geoffrey G., Gingras, Anne-Claude, Jafarnejad, Seyed Mehdi, Sonenberg, Nahum·2021·Molecular Cell
DOI 10.1016/j.molcel.2020.11.036
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Research works printed but not linked: 37

  1. Abu-Remaileh, 2017, Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes, Science, 358, 807, 10.1126/science.aan6298 · DOI
  2. Arif, 2017, EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice, Nature, 542, 357, 10.1038/nature21380 · DOI · Paper page
  3. Ben-Sahra, 2017, mTORC1 signaling and the metabolic control of cell growth, Curr. Opin. Cell Biol., 45, 72, 10.1016/j.ceb.2017.02.012 · DOI
  4. Bonfils, 2012, Leucyl-tRNA synthetase controls TORC1 via the EGO complex, Mol. Cell, 46, 105, 10.1016/j.molcel.2012.02.009 · DOI
  5. Chapat, 2017, Cap-binding protein 4EHP effects translation silencing by microRNAs, Proc. Natl. Acad. Sci. USA, 114, 5425, 10.1073/pnas.1701488114 · DOI
  6. Chen, 2018, A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, Nucleic Acids Res., 46, 3643, 10.1093/nar/gky211 · DOI
  7. Dai, 2018, Seryl-tRNA synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells, J. Dairy Sci., 101, 10456, 10.3168/jds.2018-14568 · DOI
  8. Di, 2019, The oncogene IARS2 promotes non-small cell lung cancer tumorigenesis by activating the AKT/mTOR pathway, Front. Oncol., 9, 393, 10.3389/fonc.2019.00393 · DOI
  9. Dibble, 2015, Regulation of mTORC1 by PI3K signaling, Trends Cell Biol., 25, 545, 10.1016/j.tcb.2015.06.002 · DOI
  10. Gandin, 2014, Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale, J. Vis. Exp., 87, 51455
  11. Go, 2019, A proximity biotinylation map of a human cell, bioRxiv
  12. Gu, 2017, SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway, Science, 358, 813, 10.1126/science.aao3265 · DOI
  13. Gupta, 2015, A dynamic protein interaction landscape of the human centrosome-cilium interface, Cell, 163, 1484, 10.1016/j.cell.2015.10.065 · DOI · Paper page
  14. Han, 2012, Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway, Cell, 149, 410, 10.1016/j.cell.2012.02.044 · DOI · Paper page
  15. Hara, 1998, Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism, J. Biol. Chem., 273, 14484, 10.1074/jbc.273.23.14484 · DOI
  16. Hay, 2004, Upstream and downstream of mTOR, Genes Dev., 18, 1926, 10.1101/gad.1212704 · DOI · Paper page
  17. He, 2018, Sensing and transmitting intracellular amino acid signals through reversible lysine aminoacylations, Cell Metab., 27, 151, 10.1016/j.cmet.2017.10.015 · DOI
  18. Jeong, 2019, A threonyl-tRNA synthetase-mediated translation initiation machinery, Nat. Commun., 10, 1357, 10.1038/s41467-019-09086-0 · DOI
  19. Jung, 2019, Transmembrane 4 L six family member 5 senses arginine for mTORC1 signaling, Cell Metab., 29, 1306, 10.1016/j.cmet.2019.03.005 · DOI
  20. Kim, 2002, mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery, Cell, 110, 163, 10.1016/S0092-8674(02)00808-5 · DOI
  21. Luo, 2019, GlyRS is a new mediator of amino acid-induced milk synthesis in bovine mammary epithelial cells, J. Cell. Physiol., 234, 2973, 10.1002/jcp.27115 · DOI
  22. Minajigi, 2008, RNA-assisted catalysis in a protein enzyme: The 2′-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase, Proc. Natl. Acad. Sci. USA, 105, 17748, 10.1073/pnas.0804247105 · DOI
  23. Novoa, 2014, Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo, Proc. Natl. Acad. Sci. USA, 111, E5508, 10.1073/pnas.1405994111 · DOI
  24. Nureki, 1993, Chemical modification and mutagenesis studies on zinc binding of aminoacyl-tRNA synthetases, J. Biol. Chem., 268, 15368, 10.1016/S0021-9258(18)82266-9 · DOI
  25. Sancak, 2008, The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1, Science, 320, 1496, 10.1126/science.1157535 · DOI · Paper page
  26. Sankaranarayanan, 1999, The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site, Cell, 97, 371, 10.1016/S0092-8674(00)80746-1 · DOI
  27. Saxton, 2017, mTOR signaling in growth, metabolism, and disease, Cell, 168, 960, 10.1016/j.cell.2017.02.004 · DOI · Paper page
  28. Sekiguchi, 2001, Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B, J. Biol. Chem., 276, 7246, 10.1074/jbc.M004389200 · DOI
  29. Shen, 2018, Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms, Proc. Natl. Acad. Sci. USA, 115, 9545, 10.1073/pnas.1811727115 · DOI
  30. Stafa, 2014, Functional interaction of Parkinson’s disease-associated LRRK2 with members of the dynamin GTPase superfamily, Hum. Mol. Genet., 23, 2055, 10.1093/hmg/ddt600 · DOI
  31. Torres-Larios, 2003, Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase, J. Mol. Biol., 331, 201, 10.1016/S0022-2836(03)00719-8 · DOI
  32. Wang, 2015, Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1, Science, 347, 188, 10.1126/science.1257132 · DOI
  33. Wang, 2016, A human disease-causing point mutation in mitochondrial threonyl-tRNA synthetase induces both structural and functional defects, J. Biol. Chem., 291, 6507, 10.1074/jbc.M115.700849 · DOI
  34. Wolfson, 2017, The dawn of the age of amino acid sensors for the mTORC1 pathway, Cell Metab., 26, 301, 10.1016/j.cmet.2017.07.001 · DOI
  35. Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 · DOI · Paper page
  36. Ye, 2015, GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2, Genes Dev., 29, 2331, 10.1101/gad.269324.115 · DOI
  37. Youn, 2018, High-density proximity mapping reveals the subcellular organization of mRNA-associated granules and bodies, Mol. Cell, 69, 517, 10.1016/j.molcel.2017.12.020 · DOI

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Metadata

Authors
Kim, S.-H., Choi, J.-H., Wang, P., Go, C. D., Hesketh, G. G., Gingras, A.-C., Jafarnejad, S. M., & Sonenberg, N.
ORCID
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2021-01
Volume
81
Issue
2
Pages
398-407.e4
ISSN
1097-2765
DOI
10.1016/j.molcel.2020.11.036
Cited by
62
References
9
Language
en
Licence
Funders
Canadian Institutes of Health Research

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