The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Persister cancer cells: Iron addiction and vulnerability to ferroptosis
Open accessAbstract
SUMMARY Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained occurrence of peroxidized phospholipids, which are subject to iron-mediated production of lethal oxygen radicals. This cell death modality has been detected across many organisms, including in mammals, where it can be used as a defense mechanism against pathogens or even harnessed by T cells to sensitize tumor cells toward effective killing. Conversely, ferroptosis is considered as one of the main cell death mechanisms promoting degenerative diseases. Emerging evidence suggests that ferroptosis represents a vulnerability in certain cancers. Here, we critically review recent advances linking ferroptosis vulnerabilities of dedifferentiating and persister cancer cells to the dependency of these cells on iron, a potential Achilles’ heel for small molecule intervention. We provide a perspective on the mechanisms reliant on iron that contribute to the persister cancer cell state and how this dependency may be exploited for therapeutic benefits.
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationThe CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
FSP1 is a glutathione-independent ferroptosis suppressor
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Self-citationOxidized arachidonic and adrenic PEs navigate cells to ferroptosis
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Self-citationIschaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
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Cited by
Activation of lysosomal iron triggers ferroptosis in cancer
Cañeque, T., Baron, L., Müller, S., Carmona, A., Colombeau, L., Versini, A., Solier, S., Gaillet, C., Sindikubwabo, F., Sampaio, J. L., et al. (2025) · Nature · doi:10.1038/s41586-025-08974-4 · Cited by 287
Self-citationCancer drug-tolerant persister cells: from biological questions to clinical opportunities
Russo, M., Chen, M., Mariella, E., Peng, H., Rehman, S. K., Sancho, E., Sogari, A., Toh, T. S., Balaban, N. Q., Batlle, E., et al. (2024) · Nature Reviews Cancer · doi:10.1038/s41568-024-00737-z · Cited by 210
Metadata
- Authors
- Rodriguez, R., Schreiber, S. L., & Conrad, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 82
- Issue
- 4
- Pages
- 728-740
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4200139800
- Cited by
- 267
- References
- 108
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rodriguez, R., Schreiber, S. L., & Conrad, M. (2022). Persister cancer cells: Iron addiction and vulnerability to ferroptosis. Molecular Cell. https://doi.org/10.1016/j.molcel.2021.12.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
