The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Hidden codes in mRNA: Control of gene expression by m6A
Open accessAbstract
SUMMARY Information in mRNA has largely been thought to be confined to its nucleotide sequence. However, the advent of mapping techniques to detect modified nucleotides has revealed that mRNA contains additional information in the form of chemical modifications. The most abundant modified nucleotide is N6-methyladenosine (m6A), a methyl modification of adenosine. Although early studies viewed m6A as a dynamic and tissue-specific modification, it is now clear that the mRNAs that contain m6A and the location of m6A in those transcripts are largely universal, and are influenced by gene architecture, i.e., the size and location of exons and introns. m6A can affect nuclear processes such as splicing and epigenetic regulation, but the major effect of m6A on mRNAs is to promote degradation in the cytoplasm. m6A marks a functionally related cohort of mRNAs linked to certain biological processes, including cell differentiation and cell fate determination. m6A is also enriched in other cohorts of mRNAs and can therefore affect their respective cellular processes and pathways. Future work will focus on understanding how the m6A pathway is regulated to achieve control of m6A-containing mRNAs.
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Cites
N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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Self-citationN6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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N6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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Reading, writing and erasing mRNA methylation
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Self-citationNuclear m6A Reader YTHDC1 Regulates mRNA Splicing
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YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
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m6A RNA methylation promotes XIST-mediated transcriptional repression
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Baek, A., Lee, G.-E., Golconda, S., Rayhan, A., Manganaris, A. A., Chen, S., Tirumuru, N., Yu, H., Kim, S., Kimmel, C., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01638-5 · Cited by 52
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
Quarto, G., Li Greci, A., Bizet, M., Penning, A., Primac, I., Murisier, F., Garcia-Martinez, L., Borges, R. L., Gao, Q., Cingaram, P. K. R., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.009 · Cited by 50
Metadata
- Authors
- Murakami, S., & Jaffrey, S. R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 82
- Issue
- 12
- Pages
- 2236-2251
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W4283024773
- Cited by
- 292
- References
- 17
- FWCI
- 17.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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