The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies
Abstract
Besides a critical role in innate host defence, complement activation contributes to inflammatory and immunological responses in a number of pathological conditions. Many tissues outside the liver (the primary source of complement) synthesise a variety of complement proteins, either constitutively or response to noxious stimuli. The significance of this local synthesis of complement has become clearer as a result of functional studies. It revealed that local production not only contributes to the systemic pool of complement but also influences local tissue injury and provides a link with the antigen-specific immune response. Extravascular production of complement seems particularly important at locations with poor access to circulating components and at sites of tissue stress responses, notably portals of entry of invasive microbes, such as interstitial spaces and renal tubular epithelial surfaces. Understanding the relative importance of local and systemic complement production at such locations could help to explain the differential involvement of complement in organ-specific pathology and inform the design of complement-based therapy. Here, we will describe the lessons we have learned over the last decade about the local synthesis of complement and its association with inflammatory and immunological diseases, placing emphasis on the role of local synthesis of complement in organ transplantation.
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In the citing paper
“While most complement proteins are produced in the liver, others (such as C1q, C7, Factor D, and properdin) are produced at extrahepatic sites by various cells, including monocytes, macrophages, and glial and endothelial cells [7,204,205].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [204]
In the citing paper
“in experimental mouse models, the renal tubular epithelium has been found to be more susceptible to donor kidney-derived C3”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [204]
In the citing paper
“while the fenestrated capillaries of the renal glomerulus are more prone to systemic C3 activation [204,207].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [204]
Citations
Cites
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Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,502
ROLE OF C5A IN INFLAMMATORY RESPONSES
Guo, R., & Ward, P. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115835 · Cited by 1,026
Generation of C5a in the absence of C3: a new complement activation pathway
Huber-Lang, M. S., Sarma, J. V., Zetoune, F. S., Rittirsch, D., Neff, T. A., McGuire, S. R., Lambris, J. D., Warner, R. L., Flierl, M. A., Hoesel, L. M., et al. (2006) · Nature Medicine · doi:10.1038/nm1419 · Cited by 976
CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens
Helmy, K. Y., Katschke, K. J., Gorgani, N. N., Kljavin, N. M., Elliott, J. M., Diehl, L. J., Scales, S. J., Ghilardi, N., & Campagne, M. V. L. (2006) · Cell · doi:10.1016/j.cell.2005.12.039 · Cited by 629
Local synthesis of complement component C3 regulates acute renal transplant rejection
Pratt, J. R., Basheer, S. A., & Sacks, S. H. (2002) · Nature Medicine · doi:10.1038/nm0602-582 · Cited by 534
Self-citationRegulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex
Fearon, D. T., Carroll, M. C., & Carroll, M. C. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.393 · Cited by 529
Zhou, J., Jang, Y. P., Kim, S. R., & Sparrow, J. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604255103 · Cited by 358
T-cell regulation: with complements from innate immunity
Kemper, C., & Atkinson, J. P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1994 · Cited by 347
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Items 101–111 of 111
Li, S., Schmid, K., de Vries, D. H., Korshevniuk, M., Losert, C., Oelen, R., van Blokland, I. V., Groot, H. E., Swertz, M. A., van der Harst, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22655420
Li, S., Schmid, K., de Vries, D. H., Korshevniuk, M., Losert, C., Oelen, R., van Blokland, I. V., Groot, H. E., Swertz, M. A., van der Harst, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22655396
Li, S., Schmid, K., de Vries, D. H., Korshevniuk, M., Losert, C., Oelen, R., van Blokland, I. V., Groot, H. E., Swertz, M. A., van der Harst, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22655402
Li, S., Schmid, K., de Vries, D. H., Korshevniuk, M., Losert, C., Oelen, R., van Blokland, I. V., Groot, H. E., Swertz, M. A., van der Harst, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22655444
Li, S., Schmid, K., de Vries, D. H., Korshevniuk, M., Losert, C., Oelen, R., van Blokland, I. V., Groot, H. E., Swertz, M. A., van der Harst, P., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22655399
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
Sovakova, M., Phair, I. R., Gutierrez-Lara, E. J., Nisr, R. B., Whyte, C. S., Smyth, D. J., Alqurashi, N., Yap, S., McSorley, H. J., Lamont, D., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178725
Fournis, C. L. (2019) · theses.fr (ABES) · doi:10.70675/a221c9d3zce44z4130z9af8zb3cfe7f30686
Altérations de la connectivité corticale au cours de périodes critiques du développement
Druart, M. (2020) · theses.fr (ABES) · doi:10.70675/b4f48d73za850z42b2z8dadzfad47d4f0a69
Metadata
- Authors
- Li, K., Sacks, S. H., & Zhou, W.
- Affiliations
- Guy's Hospital (GB)
- Corresponding author
- Zhou, Wuding
- Venue
- Molecular Immunology
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 44
- Issue
- 16
- Pages
- 3866-3874
- ISSN
- 0161-5890 (ISSN-L)
- OpenAlex
- W2062492768
- Cited by
- 98
- References
- 120
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Immunology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Research Councils UK
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- organ transplantation, ischemia, tissue damage, inflammation, complement activation, renal tubular epithelium, innate immunity, antigen-specific immune response
- MeSH terms
- Animals, Complement System Proteins, Complement Activation, Disease, Humans, Ischemia, Organ Specificity, Transplantation Immunology
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