Cited by 111Complement system in diseasesBiomarkers in Disease MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema

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The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies

Li, Ke, Sacks, Steven H., Zhou, Wuding·2007·Molecular Immunology

DOI 10.1016/j.molimm.2007.06.006

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Abstract

Besides a critical role in innate host defence, complement activation contributes to inflammatory and immunological responses in a number of pathological conditions. Many tissues outside the liver (the primary source of complement) synthesise a variety of complement proteins, either constitutively or response to noxious stimuli. The significance of this local synthesis of complement has become clearer as a result of functional studies. It revealed that local production not only contributes to the systemic pool of complement but also influences local tissue injury and provides a link with the antigen-specific immune response. Extravascular production of complement seems particularly important at locations with poor access to circulating components and at sites of tissue stress responses, notably portals of entry of invasive microbes, such as interstitial spaces and renal tubular epithelial surfaces. Understanding the relative importance of local and systemic complement production at such locations could help to explain the differential involvement of complement in organ-specific pathology and inform the design of complement-based therapy. Here, we will describe the lessons we have learned over the last decade about the local synthesis of complement and its association with inflammatory and immunological diseases, placing emphasis on the role of local synthesis of complement in organ transplantation.

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Authors: Li, K., Sacks, S. H., & Zhou, W.
Affiliations: Guy's Hospital (GB)
Corresponding author: Zhou, Wuding
ORCID: Li, Ke
Sacks, Steven H.
Zhou, Wuding
Venue: Molecular Immunology
Publisher: Elsevier BV
Published: 2007-09
Volume: 44
Issue: 16
Pages: 3866-3874
ISSN: 0161-5890 (ISSN-L)
DOI: 10.1016/j.molimm.2007.06.006
OpenAlex: W2062492768
Cited by: 98
References: 120
Citations by year: 2026: 3 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 5
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Immunology (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Wellcome Trust
Research Councils UK
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords: organ transplantation, ischemia, tissue damage, inflammation, complement activation, renal tubular epithelium, innate immunity, antigen-specific immune response
MeSH terms: Animals, Complement System Proteins, Complement Activation, Disease, Humans, Ischemia, Organ Specificity, Transplantation Immunology

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The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies

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